Browsing HMS Scholarly Articles by Keyword "γ-secretase"

Now showing items 1-1 of 1

    • EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastoma 

      Hiddingh, Lotte; Tannous, Bakhos A.; Teng, Jian; Tops, Bas; Jeuken, Judith; Hulleman, Esther; Boots-Sprenger, Sandra H.; Vandertop, W. Peter; Noske, David P.; Kaspers, Gertjan J.L.; Wesseling, Pieter; Wurdinger, Thomas (Impact Journals LLC, 2014)
      Glioblastoma is the most common malignant primary brain tumor. Temozolomide (TMZ) is the standard chemotherapeutic agent for this disease. However, intrinsic and acquired TMZ-resistance represents a major obstacle for this ...