Browsing HMS Scholarly Articles by Keyword "AKT signaling cascade"

Now showing items 1-2 of 2

    • EGF-Like-Domain-7 Is Required for VEGF-Induced Akt/ERK Activation and Vascular Tube Formation in an Ex Vivo Angiogenesis Assay 

      Takeuchi, Kimio; Yanai, Ryoji; Kumase, Fumiaki; Morizane, Yuki; Suzuki, Jun; Kayama, Maki; Brodowska, Katarzyna; Nakazawa, Mitsuru; Miller, Joan W.; Connor, Kip M.; Vavvas, Demetrios G. (Public Library of Science, 2014)
      EGFL7 is a secreted angiogenic factor, which in contrast to the well-known secreted angiogenic molecules VEGF and FGF-2, is almost exclusively expressed by endothelial cells and may act in an autocrine fashion. Prior studies ...

    • Interleukin-6 Secretion by Astrocytes Is Dynamically Regulated by PI3K-mTOR-Calcium Signaling 

      Codeluppi, Simone; Fernandez-Zafra, Teresa; Sandor, Katalin; Kjell, Jacob; Liu, Qingsong; Abrams, Mathew; Olson, Lars; Gray, Nathanael S.; Svensson, Camilla I.; Uhlén, Per (Public Library of Science, 2014)
      After contusion spinal cord injury (SCI), astrocytes become reactive and form a glial scar. While this reduces spreading of the damage by containing the area of injury, it inhibits regeneration. One strategy to improve the ...