Browsing HMS Scholarly Articles by Keyword "Acute Myeloid Leukemia"

Now showing items 1-3 of 3

    • Establishment of a Humanized APL Model via the Transplantation of PML-RARA-Transduced Human Common Myeloid Progenitors into Immunodeficient Mice 

      Matsushita, Hiromichi; Yahata, Takashi; Sheng, Yin; Nakamura, Yoshihiko; Muguruma, Yukari; Matsuzawa, Hideyuki; Tanaka, Masayuki; Hayashi, Hideki; Sato, Tadayuki; Damdinsuren, Anar; Onizuka, Makoto; Ito, Mamoru; Miyachi, Hayato; Pandolfi, Pier Paolo; Ando, Kiyoshi (Public Library of Science, 2014)
      Recent advances in cancer biology have revealed that many malignancies possess a hierarchal system, and leukemic stem cells (LSC) or leukemia-initiating cells (LIC) appear to be obligatory for disease progression. Acute ...

    • Icariside II Induces Apoptosis in U937 Acute Myeloid Leukemia Cells: Role of Inactivation of STAT3-Related Signaling 

      Kang, Sang-Hun; Jeong, Soo-Jin; Kim, Sun-Hee; Kim, Ji-Hyun; Koh, Wonil; Kim, Sung-Hoon; Jung, Ji Hoon; Kim, Jung Hyo; Kim, Dae Keun; Chen, Chang-Yan (Public Library of Science, 2012)
      Background: The aim of this study is to determine anti-cancer effect of Icariside II purified from the root of Epimedium koreanum Nakai on human acute myeloid leukemia (AML) cell line U937. Methodology/Principal Findings ...

    • Mutations in UBA3 Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Human Leukemic Cells 

      Xu, G. Wei; Toth, Julia I.; da Silva, Sara R.; Paiva, Stacey-Lynn; Lukkarila, Julie L.; Hurren, Rose; Maclean, Neil; Sukhai, Mahadeo A.; Bhattacharjee, Rabindra N.; Goard, Carolyn A.; Gunning, Patrick T.; Dhe-Paganon, Sirano; Petroski, Matthew D.; Schimmer, Aaron D. (Public Library of Science, 2014)
      The NEDD8-activating enzyme (NAE) initiates neddylation, the cascade of post-translational NEDD8 conjugation onto target proteins. MLN4924, a selective NAE inhibitor, has displayed preclinical anti-tumor activity in vitro ...