Browsing HMS Scholarly Articles by Keyword "Animal model"

Now showing items 1-3 of 3

    • Direct detection of alpha synuclein oligomers in vivo 

      Dimant, Hemi; Kalia, Suneil K; Kalia, Lorraine V; Zhu, Liya N; Kibuuka, Laura; Ebrahimi-Fakhari, Darius; McFarland, Nikolaus R; Fan, Zhanyun; Hyman, Bradley T; McLean, Pamela J (BioMed Central, 2013)
      Background: Rat models of Parkinson’s disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches. Models were developed using toxins such as MPTP or 6-OHDA to ...

    • Treatment with FTY720 has no beneficial effects on short-term outcome in an experimental model of intracerebral hemorrhage 

      Schlunk, Frieder; Pfeilschifter, Waltraud; Yigitkanli, Kazim; Lo, Eng H.; Foerch, Christian (BioMed Central, 2016)
      Background: No evidence-based therapy is available for patients with acute intracerebral hemorrhage (ICH). In view of the profound inflammatory reaction in the perilesional tissue, we investigated in a well-characterized ...

    • X-linked myotubular myopathy in Rottweiler dogs is caused by a missense mutation in Exon 11 of the MTM1 gene 

      Shelton, G Diane; Rider, Branden E; Child, Georgina; Tzannes, Sophia; Guo, Ling T; Moghadaszadeh, Behzad; Troiano, Emily C; Haase, Bianca; Wade, Claire M; Beggs, Alan H (BioMed Central, 2015)
      Background: Congenital and inherited myopathies in dogs are faithful models of human muscle diseases and are being recognized with increasing frequency. In fact, canine models of dystrophin deficient muscular dystrophy and ...