Now showing items 1-20 of 30

    • 4-Phenylbutyrate Attenuates the ER Stress Response and Cyclic AMP Accumulation in DYT1 Dystonia Cell Models 

      Cho, Jin A.; Zhang, Xuan; Miller, Gregory M.; Lencer, Wayne I.; Nery, Flavia C. (Public Library of Science, 2014)
      Dystonia is a neurological disorder in which sustained muscle contractions induce twisting and repetitive movements or abnormal posturing. DYT1 early-onset primary dystonia is the most common form of hereditary dystonia ...
    • Action Initiation in the Human Dorsal Anterior Cingulate Cortex 

      Srinivasan, Lakshminarayan; Asaad, Wael F.; Ginat, Daniel T; Gale, John T.; Dougherty, Darin Dean; Williams, Ziv; Sejnowski, Terrence J.; Eskandar, Emad (Public Library of Science, 2013)
      The dorsal anterior cingulate cortex (dACC) has previously been implicated in processes that influence action initiation. In humans however, there has been little direct evidence connecting dACC to the temporal onset of ...
    • Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language 

      Eicher, John D.; Powers, Natalie R.; Cho, Kelly; Miller, Laura L.; Mueller, Kathryn L.; Ring, Susan M.; Tomblin, J. Bruce; Gruen, Jeffrey R. (Public Library of Science, 2013)
      Language impairment (LI) and reading disability (RD) are common pediatric neurobehavioral disorders that frequently co-occur, suggesting they share etiological determinants. Recently, our group identified prenatal nicotine ...
    • Astrocyte-Specific Disruption of SynCAM1 Signaling Results in ADHD-Like Behavioral Manifestations 

      Sandau, Ursula S.; Alderman, Zefora; Corfas, Gabriel; Ojeda, Sergio R.; Raber, Jacob (Public Library of Science, 2012)
      SynCAM1 is an adhesion molecule involved in synaptic differentiation and organization. SynCAM1 is also expressed in astroglial cells where it mediates astrocyte-to astrocyte and glial-neuronal adhesive communication. In ...
    • Behavioral and Neural Correlates of Executive Functioning in Musicians and Non-Musicians 

      Zuk, Jennifer; Benjamin, Christopher; Kenyon, Arnold; Gaab, Nadine (Public Library of Science, 2014)
      Executive functions (EF) are cognitive capacities that allow for planned, controlled behavior and strongly correlate with academic abilities. Several extracurricular activities have been shown to improve EF, however, the ...
    • Bioenergetic Measurements in Children with Bipolar Disorder: A Pilot \(^{31}\)P Magnetic Resonance Spectroscopy Study 

      Sikoglu, Elif M.; Jensen, John Eric; Vitaliano, Gordana Dragan; Liso Navarro, Ana A.; Renshaw, Perry Franklin; Frazier, Jean A.; Moore, Constance M. (Public Library of Science, 2013)
      Background: Research exploring Bipolar Disorder (BD) phenotypes and mitochondrial dysfunction, particularly in younger subjects, has been insufficient to date. Previous studies have found abnormal cerebral pH levels in ...
    • Construction of a Global Pain Systems Network Highlights Phospholipid Signaling as a Regulator of Heat Nociception 

      Neely, G. Gregory; Rao, Shuan; Costigan, Michael; Mair, Norbert; Racz, Ildiko; Milinkeviciute, Giedre; Meixner, Arabella; Nayanala, Swetha; Griffin, Robert Stewart; Belfer, Inna; Dai, Feng; Smith, Shad; Diatchenko, Luda; Marengo, Stefano; Haubner, Bernhard J.; Novatchkova, Maria; Gibson, Dustin; Maixner, William; Pospisilik, J. Andrew; Hirsch, Emilio; Whishaw, Ian Q.; Zimmer, Andreas; Gupta, Vaijayanti; Sasaki, Junko; Kanaho, Yasunori; Sasaki, Takehiko; Kress, Michaela; Woolf, Clifford; Penninger, Josef M. (Public Library of Science, 2012)
      The ability to perceive noxious stimuli is critical for an animal's survival in the face of environmental danger, and thus pain perception is likely to be under stringent evolutionary pressure. Using a neuronal-specific ...
    • The Constructive Nature of Affective Vision: Seeing Fearful Scenes Activates Extrastriate Body Area 

      Sinke, Charlotte B. A.; Van den Stock, Jan; Goebel, Rainer; de Gelder, Beatrice M.L. (Public Library of Science, 2012)
      It is part of basic emotions like fear or anger that they prepare the brain to act adaptively. Hence scenes representing emotional events are normally associated with characteristic adaptive behavior. Normally, face and ...
    • Contagious disruptions and complexity traps in economic development 

      Brummitt, Charles D.; Huremovic, Kenan; Pin, Paolo; Bonds, Matthew H; Vega-Redondo, Fernando (Springer Science and Business Media LLC, 2017-09)
      Poor economies not only produce less; they typically produce things that involve fewer inputs and fewer intermediate steps. Yet the supply chains of poor countries face more frequent disruptions—delivery failures, faulty ...
    • Daytime Sleep Enhances Consolidation of the Spatial but Not Motoric Representation of Motor Sequence Memory 

      Albouy, Geneviève; Fogel, Stuart; Pottiez, Hugo; Nguyen, Vo An; Ray, Laura; Lungu, Ovidiu; Carrier, Julie; Robertson, Edwin Malcolm; Doyon, Julien (Public Library of Science, 2013)
      Motor sequence learning is known to rely on more than a single process. As the skill develops with practice, two different representations of the sequence are formed: a goal representation built under spatial allocentric ...
    • Differential Expression of Exosomal microRNAs in Prefrontal Cortices of Schizophrenia and Bipolar Disorder Patients 

      Banigan, Meredith G.; Kao, Patricia F.; Kozubek, James A.; Winslow, Ashley R; Medina, Juan; Costa, Joan; Schmitt, Andrea; Schneider, Anja; Cabral, Howard; Cagsal-Getkin, Ozge; Vanderburg, Charles R.; Delalle, Ivana (Public Library of Science, 2013)
      Exosomes are cellular secretory vesicles containing microRNAs (miRNAs). Once secreted, exosomes are able to attach to recipient cells and release miRNAs potentially modulating the function of the recipient cell. We ...
    • Dissociable Influences of Auditory Object vs. Spatial Attention on Visual System Oscillatory Activity 

      Ahveninen, Jyrki Pekka; Jääskeläinen, Iiro P.; Belliveau, John William; Hämäläinen, Matti; Lin, Fa-Hsuan; Raij, Tommi A. (Public Library of Science, 2012)
      Given that both auditory and visual systems have anatomically separate object identification (“what”) and spatial (“where”) pathways, it is of interest whether attention-driven cross-sensory modulations occur separately ...
    • Do Multielement Visual Tracking and Visual Search Draw Continuously on the Same Visual Attention Resources? 

      Alvarez, George; Horowitz, Todd S.; Arsenio, Helga C.; DiMase, Jennifer S.; Wolfe, Jeremy (American Psychological Association (APA), 2005)
      Multielement visual tracking and visual search are 2 tasks that are held to require visual-spatial attention. The authors used the attentional operating characteristic (AOC) method to determine whether both tasks draw ...
    • Dynamic computational phenotyping of human cognition 

      Schurr, Roey; Reznik, Daniel; Hillman, Hanna; Bhui, Rahul; Gershman, Samuel J. (Springer Science and Business Media LLC, 2024-02-08)
      Computational phenotyping has emerged as a powerful tool for characterizing individual variability across a variety of cognitive domains. An individual's computational phenotype is defined as a set of mechanistically ...
    • Effects of Exposure to Intermittent versus Continuous Red Light on Human Circadian Rhythms, Melatonin Suppression, and Pupillary Constriction 

      Ho Mien, Ivan; Chua, Eric Chern-Pin; Lau, Pauline; Tan, Luuan-Chin; Lee, Ivan Tian-Guang; Yeo, Sing-Chen; Tan, Sara Shuhui; Gooley, Joshua J. (Public Library of Science, 2014)
      Exposure to light is a major determinant of sleep timing and hormonal rhythms. The role of retinal cones in regulating circadian physiology remains unclear, however, as most studies have used light exposures that also ...
    • Genome-wide association study identifies 48 common genetic variants associated with handedness 

      Cuellar-Partida, Gabriel; Tung, Joyce Y.; Eriksson, Nicholas; Albrecht, Eva; Aliev, Fazil; Andreassen, Ole A.; Barroso, Inês; Beckmann, Jacques S.; Boks, Marco P.; Boomsma, Dorret I.; Boyd, Heather A.; Breteler, Monique M. B.; Campbell, Harry; Chasman, Daniel I.; Cherkas, Lynn F.; Davies, Gail; de Geus, Eco J. C.; Deary, Ian J.; Deloukas, Panos; Dick, Danielle M.; Duffy, David L.; Eriksson, Johan G.; Esko, Tõnu; Feenstra, Bjarke; Geller, Frank; Gieger, Christian; Giegling, Ina; Gordon, Scott D.; Han, Jiali; Hansen, Thomas F.; Hartmann, Annette M.; Hayward, Caroline; Heikkilä, Kauko; Hicks, Andrew A.; Hirschhorn, Joel N.; Hottenga, Jouke-Jan; Huffman, Jennifer E.; Hwang, Liang-Dar; Ikram, M. Arfan; Kaprio, Jaakko; Kemp, John P.; Khaw, Kay-Tee; Klopp, Norman; Konte, Bettina; Kutalik, Zoltan; Lahti, Jari; Li, Xin; Loos, Ruth J. F.; Luciano, Michelle; Magnusson, Sigurdur H.; Mangino, Massimo; Marques-Vidal, Pedro; Martin, Nicholas G.; McArdle, Wendy L.; McCarthy, Mark I.; Medina-Gomez, Carolina; Melbye, Mads; Melville, Scott A.; Metspalu, Andres; Milani, Lili; Mooser, Vincent; Nelis, Mari; Nyholt, Dale R.; O’Connell, Kevin S.; Ophoff, Roel A.; Palmer, Cameron; Palotie, Aarno; Palviainen, Teemu; Pare, Guillaume; Paternoster, Lavinia; Peltonen, Leena; Penninx, Brenda W. J. H.; Polasek, Ozren; Pramstaller, Peter P.; Prokopenko, Inga; Raikkonen, Katri; Ripatti, Samuli; Rivadeneira, Fernando; Rudan, Igor; Rujescu, Dan; Smit, Johannes H.; Smith, George Davey; Smoller, Jordan W.; Soranzo, Nicole; Spector, Tim D.; Pourcain, Beate St; Starr, John M.; Stefánsson, Hreinn; Steinberg, Stacy; Teder-Laving, Maris; Thorleifsson, Gudmar; Stefánsson, Kári; Timpson, Nicholas J.; Uitterlinden, André G.; van Duijn, Cornelia M.; van Rooij, Frank J. A.; Vink, Jaqueline M.; Vollenweider, Peter; Vuoksimaa, Eero; Waeber, Gérard; Wareham, Nicholas J.; Warrington, Nicole; Waterworth, Dawn; Werge, Thomas; Wichmann, H.-Erich; Widen, Elisabeth; Willemsen, Gonneke; Wright, Alan F.; Wright, Margaret J.; Xu, Mousheng; Zhao, Jing Hua; Kraft, Phillip; Hinds, David A.; Lindgren, Cecilia M.; Mägi, Reedik; Neale, Benjamin M.; Evans, David M.; Medland, Sarah E. (Springer Science and Business Media LLC, 2020-09-28)
      Handedness, a consistent asymmetry in skill or use of the hands, has been studied extensively because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using ...
    • The Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway 

      Talos, Delia Maria; Sun, Hongyu; Zhou, Xiangping; Fitzgerald, Erin C.; Jackson, Michele C.; Klein, Peter M.; Lan, Victor J.; Joseph, Annelise; Jensen, Frances Elizabeth (Public Library of Science, 2012)
      Early life seizures can result in chronic epilepsy, cognitive deficits and behavioral changes such as autism, and conversely epilepsy is common in autistic children. We hypothesized that during early brain development, ...
    • Lack of Tryptophan Hydroxylase-1 in Mice Results in Gait Abnormalities 

      Suidan, Georgette L; Duerschmied, Daniel; Dillon, Gregory; Vanderhorst, Veronique; Hampton, Thomas G.; Wong, Siu Ling Christine; Voorhees, Jaymie R.; Wagner, Denisa D. (Public Library of Science, 2013)
      The role of peripheral serotonin in nervous system development is poorly understood. Tryptophan hydroxylase-1 (TPH1) is expressed by non-neuronal cells including enterochromaffin cells of the gut, mast cells and the pineal ...
    • Neurological Soft Signs in Individuals with Pathological Gambling 

      Elman, Igor; Gurvits, Tamara V.; Tschibelu, Evelyne; Spring, Justin Douglas; Lasko, Natasha B.; Pitman, roger k (Public Library of Science, 2013)
      Increased neurological soft signs (NSSs) have been found in a number of neuropsychiatric syndromes, including chemical addiction. The present study examined NSSs related to perceptual-motor and visuospatial processing in ...
    • Orientation-Specificity of Adaptation: Isotropic Adaptation Is Purely Monocular 

      Cass, John; Johnson, Ameika; Bex, Peter; Alais, David (Public Library of Science, 2012)
      Numerous studies have found that prolonged exposure to grating stimuli reduces sensitivity to subsequently presented gratings, most evidently when the orientations of the adapting and test patterns are similar. The rate ...