Browsing HMS Scholarly Articles by Keyword "Biophysics"
Now showing items 1-20 of 55
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Association between Amylin and Amyloid-β Peptides in Plasma in the Context of Apolipoprotein E4 Allele
(Public Library of Science, 2014)Amylin, a pancreatic peptide that readily crosses the blood brain barrier (BBB), and amyloid-beta peptide (Aβ), the main component of amyloid plaques and a major component of Alzheimer's disease (AD) pathology in the brain, ... -
Binary DNA Nanostructures for Data Encryption
(Public Library of Science, 2012)We present a simple and secure system for encrypting and decrypting information using DNA self-assembly. Binary data is encoded in the geometry of DNA nanostructures with two distinct conformations. Removing or leaving out ... -
Cell Elasticity Determines Macrophage Function
(Public Library of Science, 2012)Macrophages serve to maintain organ homeostasis in response to challenges from injury, inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has been understood as being the central ... -
Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation
(Public Library of Science, 2012)Adipose tissue-derived stem cells (ASCs) are considered as an attractive stem cell source for tissue engineering and regenerative medicine. We compared human bone marrow-derived mesenchymal stem cells (hMSCs) and hASCs ... -
Chromatin Loops as Allosteric Modulators of Enhancer-Promoter Interactions
(Public Library of Science, 2014)The classic model of eukaryotic gene expression requires direct spatial contact between a distal enhancer and a proximal promoter. Recent Chromosome Conformation Capture (3C) studies show that enhancers and promoters are ... -
Complex Structure of Engineered Modular Domains Defining Molecular Interaction between ICAM-1 and Integrin LFA-1
(Public Library of Science, 2012)Intermolecular contacts between integrin LFA-1 (αLβ2) and ICAM-1 derive solely from the integrin αL I domain and the first domain (D1) of ICAM-1. This study presents a crystal structure of the engineered complex of the αL ... -
The Complexity of Standing Postural Control in Older Adults: A Modified Detrended Fluctuation Analysis Based upon the Empirical Mode Decomposition Algorithm
(Public Library of Science, 2013)Human aging into senescence diminishes the capacity of the postural control system to adapt to the stressors of everyday life. Diminished adaptive capacity may be reflected by a loss of the fractal-like, multiscale complexity ... -
Concurrent Chemoradiation for Vaginal Cancer
(Public Library of Science, 2013)Background: It is not known whether the addition of chemotherapy to radiation therapy improves outcomes in primary vaginal cancer. Here, we review clinical outcomes in patients with primary vaginal cancer treated with ... -
Control Centrality and Hierarchical Structure in Complex Networks
(Public Library of Science, 2012)We introduce the concept of control centrality to quantify the ability of a single node to control a directed weighted network. We calculate the distribution of control centrality for several real networks and find that ... -
Controlled Ultrasound-Induced Blood-Brain Barrier Disruption Using Passive Acoustic Emissions Monitoring
(Public Library of Science, 2012)The ability of ultrasonically-induced oscillations of circulating microbubbles to permeabilize vascular barriers such as the blood-brain barrier (BBB) holds great promise for noninvasive targeted drug delivery. A major ... -
Development of Antipsychotic Medications with Novel Mechanisms of Action Based on Computational Modeling of Hippocampal Neuropathology
(Public Library of Science, 2013)A large number of cellular level abnormalities have been identified in the hippocampus of schizophrenic subjects. Nonetheless, it remains uncertain how these pathologies interact at a system level to create clinical symptoms, ... -
Dual-Phase Cardiac Diffusion Tensor Imaging with Strain Correction
(Public Library of Science, 2014)Purpose In this work we present a dual-phase diffusion tensor imaging (DTI) technique that incorporates a correction scheme for the cardiac material strain, based on 3D myocardial tagging. Methods: In vivo dual-phase cardiac ... -
Enrichment of Mutations in Multiple DNA Sequences Using COLD-PCR in Emulsion
(Public Library of Science, 2012)Background: Multiplex detection of low-level mutant alleles in the presence of wild-type DNA would be useful for several fields of medicine including cancer, pre-natal diagnosis and infectious diseases. COLD-PCR is a ... -
Epigenetic Landscapes Explain Partially Reprogrammed Cells and Identify Key Reprogramming Genes
(Public Library of Science, 2014)A common metaphor for describing development is a rugged “epigenetic landscape” where cell fates are represented as attracting valleys resulting from a complex regulatory network. Here, we introduce a framework for explicitly ... -
Evaluation and Correction for Optical Scattering Variations in Laser Speckle Rheology of Biological Fluids
(Public Library of Science, 2013)Biological fluids fulfill key functionalities such as hydrating, protecting, and nourishing cells and tissues in various organ systems. They are capable of these versatile tasks owing to their distinct structural and ... -
Extensive Alternative Splicing of the Repressor Element Silencing Transcription Factor Linked to Cancer
(Public Library of Science, 2013)The repressor element silencing transcription factor (REST) is a coordinate transcriptional and epigenetic regulator which functions as a tumor suppressor or an oncogene depending on cellular context, and a truncated splice ... -
Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion
(Public Library of Science, 2012)Birt-Hogg-Dube (BHD) is a tumor suppressor gene syndrome associated with fibrofolliculomas, cystic lung disease, and chromophobe renal cell carcinoma. In seeking to elucidate the pathogenesis of BHD, we discovered a physical ... -
Gas2l3, a Novel Constriction Site-Associated Protein Whose Regulation Is Mediated by the \(APC/C^{Cdh1}\) Complex
(Public Library of Science, 2013)Growth arrest-specific 2-like protein 3 (Gas2l3) was recently identified as an Actin/Tubulin cross-linker protein that regulates cytokinesis. Using cell-free systems from both frog eggs and human cells, we show that the ... -
A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition
(Public Library of Science, 2013)The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing ... -
Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice
(Public Library of Science, 2016)Members of the TRP superfamily of ion channels mediate mechanosensation in some organisms, and have been suggested as candidates for the mechanotransduction channel in vertebrate hair cells. Some TRP channels can be ruled ...