Browsing HMS Scholarly Articles by Keyword "CANCER"

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    • Small-molecule targeting of translation initiation for cancer therapy 

      Aktas, Bertal H.; Qiao, Yuan; Ozdelen, Esra; Schubert, Roland; Sevinc, Sema; Harbinski, Fred; Grubissich, Luciano; Singer, Samuel; Halperin, Jose A. (Impact Journals LLC, 2013)
      Translation initiation plays a critical role in the regulation of cell growth and tumorigenesis. We report here that inhibiting translation initiation through induction of eIF2α phosphorylation by small-molecular-weight ...