Browsing HMS Scholarly Articles by Keyword "CNS, central nervous system"
Now showing items 1-3 of 3
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Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity
(Elsevier, 2014)Objective: Lipoprotein lipase (LPL) is a key regulator of circulating triglyceride rich lipoprotein hydrolysis. In brain LPL regulates appetite and energy expenditure. Angiopoietin-like 4 (Angptl4) is a secreted protein ... -
Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis★
(Elsevier, 2013)Insulin receptor substrates (Irs1, 2, 3 and Irs4) mediate the actions of insulin/IGF1 signaling. They have similar structure, but distinctly regulate development, growth, and metabolic homeostasis. Irs2 contributes to ... -
The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis
(Elsevier, 2015)Objective: Hypothalamic agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) expressing neurons play critical roles in control of energy balance. Glutamatergic input via n-methyl-d-aspartate receptors (NMDARs) is ...