Browsing HMS Scholarly Articles by Keyword "Cell Cycle and Cell Division"

Now showing items 1-10 of 10

    • 53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks 

      Guirouilh-Barbat, Josée; Gelot, Camille; Xie, Anyong; Dardillac, Elodie; Scully, Ralph; Lopez, Bernard S. (Public Library of Science, 2016)
      DNA double-strand breaks (DSB) are very harmful lesions that can generate genome rearrangements. In this study, we used intrachromosomal reporters to compare both the efficiency and accuracy of end-joining occurring with ...

    • AS1411-Induced Growth Inhibition of Glioma Cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via Nucleolin 

      Cheng, Ye; Zhao, Gang; Zhang, Siwen; Nigim, Fares; Zhou, Guangtong; Yu, Zhiyun; Song, Yang; Chen, Yong; Li, Yunqian (Public Library of Science, 2016)
      AS1411 binds nucleolin (NCL) and is the first oligodeoxynucleotide aptamer to reach phase I and II clinical trials for the treatment of several cancers. However, the mechanisms by which AS1411 targets and kills glioma cells ...

    • Enhanced Rb/E2F and TSC/mTOR Pathways Induce Synergistic Inhibition in PDGF-Induced Proliferation in Vascular Smooth Muscle Cells 

      Li, Yue; Li, Xuan; Liu, Jie; Guo, Wei; Zhang, Hongchao; Wang, Jianchang (Public Library of Science, 2017)
      Platelet-derived growth factor (PDGF) plays an essential role in proliferation of vascular smooth muscle cells (VSMCs). The Rb/E2F and TSC/mTOR pathways contribute to the proliferation of VSMCs, but its exact roles in ...

    • The Evolution of Quorum Sensing as a Mechanism to Infer Kinship 

      Schluter, Jonas; Schoech, Armin P.; Foster, Kevin R.; Mitri, Sara (Public Library of Science, 2016)
      Bacteria regulate many phenotypes via quorum sensing systems. Quorum sensing is typically thought to evolve because the regulated cooperative phenotypes are only beneficial at certain cell densities. However, quorum sensing ...

    • Genetic Deletion of SEPT7 Reveals a Cell Type-Specific Role of Septins in Microtubule Destabilization for the Completion of Cytokinesis 

      Menon, Manoj B.; Sawada, Akihiro; Chaturvedi, Anuhar; Mishra, Pooja; Schuster-Gossler, Karin; Galla, Melanie; Schambach, Axel; Gossler, Achim; Förster, Reinhold; Heuser, Michael; Kotlyarov, Alexey; Kinoshita, Makoto; Gaestel, Matthias (Public Library of Science, 2014)
      Cytokinesis terminates mitosis, resulting in separation of the two sister cells. Septins, a conserved family of GTP-binding cytoskeletal proteins, are an absolute requirement for cytokinesis in budding yeast. We demonstrate ...

    • Multi-Scale Imaging and Informatics Pipeline for In Situ Pluripotent Stem Cell Analysis 

      Gorman, Bryan R.; Lu, Junjie; Baccei, Anna; Lowry, Nathan C.; Purvis, Jeremy E.; Mangoubi, Rami S.; Lerou, Paul H. (Public Library of Science, 2014)
      Human pluripotent stem (hPS) cells are a potential source of cells for medical therapy and an ideal system to study fate decisions in early development. However, hPS cells cultured in vitro exhibit a high degree of ...

    • Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration 

      Lee, Sang Goo; Huang, Mingqian; Obholzer, Nikolaus D.; Sun, Shan; Li, Wenyan; Petrillo, Marco; Dai, Pu; Zhou, Yi; Cotanche, Douglas A.; Megason, Sean G.; Li, Huawei; Chen, Zheng-Yi (Public Library of Science, 2016)
      Unlike mammals, the non-mammalian vertebrate inner ear can regenerate the sensory cells, hair cells, either spontaneously or through induction after hair cell loss, leading to hearing recovery. The mechanisms underlying ...

    • Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo 

      Odajima, Junko; Saini, Siddharth; Jung, Piotr; Ndassa-Colday, Yasmine; Ficaro, Scott; Geng, Yan; Marco, Eugenio; Michowski, Wojciech; Wang, Yaoyu E.; DeCaprio, James A.; Litovchick, Larisa; Marto, Jarrod; Sicinski, Piotr (Public Library of Science, 2016)
      E-type cyclins (cyclins E1 and E2) are components of the cell cycle machinery that has been conserved from yeast to humans. The major function of E-type cyclins is to drive cell division. It is unknown whether in addition ...

    • Quantifying Clonal and Subclonal Passenger Mutations in Cancer Evolution 

      Bozic, Ivana; Gerold, Jeffrey M.; Nowak, Martin A. (Public Library of Science, 2016)
      The vast majority of mutations in the exome of cancer cells are passengers, which do not affect the reproductive rate of the cell. Passengers can provide important information about the evolutionary history of an individual ...

    • RNA Stimulates Aurora B Kinase Activity during Mitosis 

      Jambhekar, Ashwini; Emerman, Amy B.; Schweidenback, Caterina T. H.; Blower, Michael D. (Public Library of Science, 2014)
      Accurate chromosome segregation is essential for cell viability. The mitotic spindle is crucial for chromosome segregation, but much remains unknown about factors that regulate spindle assembly. Recent work implicates RNA ...