Now showing items 1-2 of 2

    • Lupus-Prone Mice Fail to Raise Antigen-Specific T Cell Responses to Intracellular Infection 

      Lieberman, Linda A.; Tsokos, George C. (Public Library of Science, 2014)
      Systemic lupus erythematosus (SLE) is characterized by multiple cellular abnormalities culminating in the production of autoantibodies and immune complexes, resulting in tissue inflammation and organ damage. Besides active ...
    • TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection 

      Jayaraman, Pushpa; Jacques, Miye K.; Zhu, Chen; Steblenko, Katherine M.; Stowell, Britni L.; Madi, Asaf; Anderson, Ana C.; Kuchroo, Vijay K.; Behar, Samuel M. (Public Library of Science, 2016)
      While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear. One hypothesis is that T cell exhaustion impairs ...