Browsing HMS Scholarly Articles by Keyword "ChIP-seq"
Now showing items 1-6 of 6
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ChiLin: a comprehensive ChIP-seq and DNase-seq quality control and analysis pipeline
(BioMed Central, 2016)Background: Transcription factor binding, histone modification, and chromatin accessibility studies are important approaches to understanding the biology of gene regulation. ChIP-seq and DNase-seq have become the standard ... -
Functionally distinct patterns of nucleosome remodeling at enhancers in glucocorticoid-treated acute lymphoblastic leukemia
(BioMed Central, 2015)Background: Precise nucleosome positioning is an increasingly recognized feature of promoters and enhancers, reflecting complex contributions of DNA sequence, nucleosome positioning, histone modification and transcription ... -
Genome-Wide Analysis of ETS-Family DNA-Binding In Vitro and In Vivo
(Nature Publishing Group, 2010)Members of the large ETS family of transcription factors (TFs) have highly similar DNA-binding domains (DBDs)—yet they have diverse functions and activities in physiology and oncogenesis. Some differences in DNA-binding ... -
An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer
(Springer Nature, 2013)Lineage-restricted transcription factors (TFs) are frequently mutated or overexpressed in cancer and contribute toward malignant behaviors, but the molecular bases of their oncogenic properties are largely unknown. Because ... -
Large-Scale Quality Analysis of Published ChIP-seq Data
(Genetics Society of America, 2014)ChIP-seq has become the primary method for identifying in vivo protein–DNA interactions on a genome-wide scale, with nearly 800 publications involving the technique appearing in PubMed as of December 2012. Individually and ... -
Multiplexed Illumina sequencing libraries from picogram quantities of DNA
(BioMed Central, 2013)Background: High throughput sequencing is frequently used to discover the location of regulatory interactions on chromatin. However, techniques that enrich DNA where regulatory activity takes place, such as chromatin ...