Browsing HMS Scholarly Articles by Keyword "Chondrocytes"

Now showing items 1-4 of 4

    • miRNAs in Bone Development 

      Papaioannou, Garyfallia (Bentham Science Publishers, 2015)
      Skeletal development is a multistage process during which mesenchymal progenitor cells undergo proliferation and differentiation and subsequently give rise to bone and cartilage forming cells. Each step is regulated by ...

    • NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis 

      Yang, Siyoung; Ryu, Je-Hwang; Oh, Hwanhee; Jeon, Jimin; Kwak, Ji-Sun; Kim, Jin-Hong; Kim, Hyun Ah; Chun, Churl-Hong; Chun, Jang-Soo (BMJ Publishing Group, 2015)
      Objective: Hypoxia-inducible factor 2α (HIF-2α), encoded by Epas1, causes osteoarthritic cartilage destruction by regulating the expression of matrix-degrading enzymes. We undertook this study to explore the role of ...

    • PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage 

      Vasheghani, Faezeh; Zhang, Yue; Li, Ying-Hua; Blati, Meryem; Fahmi, Hassan; Lussier, Bertrand; Roughley, Peter; Lagares, David; Endisha, Helal; Saffar, Bahareh; Lajeunesse, Daniel; Marshall, Wayne K; Rampersaud, Y Raja; Mahomed, Nizar N; Gandhi, Rajiv; Pelletier, Jean-Pierre; Martel-Pelletier, Johanne; Kapoor, Mohit (BMJ Publishing Group, 2015)
      Objectives: We have previously shown that peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor, is essential for the normal growth and development of cartilage. In the present study, we created ...

    • Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1 

      Ge, Xianpeng; Ritter, Susan Y.; Tsang, Kelly; Shi, Ruirui; Takei, Kohtaro; Aliprantis, Antonios O. (Public Library of Science, 2016)
      Cartilage acidic protein 1 (CRTAC1) was recently identified as an elevated protein in the synovial fluid of patients with osteoarthritis (OA) by a proteomic analysis. This gene is also upregulated in both human and mouse ...