Browsing HMS Scholarly Articles by Keyword "Clinical Laboratory Sciences"

Now showing items 1-9 of 9

    • Association between Amylin and Amyloid-β Peptides in Plasma in the Context of Apolipoprotein E4 Allele 

      Qiu, Wei Qiao; Wallack, Max; Dean, Michael; Liebson, Elizabeth; Mwamburi, Mkaya; Zhu, Haihao (Public Library of Science, 2014)
      Amylin, a pancreatic peptide that readily crosses the blood brain barrier (BBB), and amyloid-beta peptide (Aβ), the main component of amyloid plaques and a major component of Alzheimer's disease (AD) pathology in the brain, ...

    • Evaluation of an Electricity-free, Culture-based Approach for Detecting Typhoidal Salmonella Bacteremia during Enteric Fever in a High Burden, Resource-limited Setting 

      Andrews, Jason R.; Prajapati, Krishna G.; Eypper, Elizabeth; Shrestha, Poojan; Shakya, Mila; Pathak, Kamal R.; Joshi, Niva; Tiwari, Priyanka; Risal, Manisha; Koirala, Samir; Karkey, Abhilasha; Dongol, Sabina; Wen, Shawn; Smith, Amy B.; Maru, Duncan; Basnyat, Buddha; Baker, Stephen; Farrar, Jeremy; Ryan, Edward T.; Hohmann, Elizabeth; Arjyal, Amit (Public Library of Science, 2013)
      Background: In many rural areas at risk for enteric fever, there are few data on Salmonella enterica serotypes Typhi (S. Typhi) and Paratyphi (S. Paratyphi) incidence, due to limited laboratory capacity for microbiologic ...

    • Extracting Physician Group Intelligence from Electronic Health Records to Support Evidence Based Medicine 

      Weber, Griffin M.; Kohane, Isaac S. (Public Library of Science, 2013)
      Evidence-based medicine employs expert opinion and clinical data to inform clinical decision making. The objective of this study is to determine whether it is possible to complement these sources of evidence with information ...

    • Filter Paper Blood Spot Enzyme Linked Immunoassay for Adiponectin and Application in the Evaluation of Determinants of Child Insulin Sensitivity 

      Martin, Richard M.; Patel, Rita; Oken, Emily; Thompson, Jennifer; Zinovik, Alexander; Kramer, Michael S.; Vilchuck, Konstantin; Bogdanovich, Natalia; Sergeichick, Natalia; Foo, Ying; Gusina, Nina (Public Library of Science, 2013)
      Background: Adiponectin is an adipocyte-derived hormone that acts as a marker of insulin sensitivity. Bloodspot sampling by fingerstick onto filter paper may increase the feasibility of large-scale studies of the determinants ...

    • Healthy Dietary Interventions and Lipoprotein (a) Plasma Levels: Results from the Omni Heart Trial 

      Haring, Bernhard; Wyler von Ballmoos, Moritz C.; Appel, Lawrence J.; Sacks, Frank M. (Public Library of Science, 2014)
      Background: Increased lipoprotein(a) [Lp(a)] levels are associated with atherosclerotic cardiovascular disease. Studies of dietary interventions on changes in Lp(a) are sparse. We aimed to compare the effects of three ...

    • The Human Urine Metabolome 

      Bouatra, Souhaila; Aziat, Farid; Mandal, Rupasri; Guo, An Chi; Wilson, Michael R.; Knox, Craig; Bjorndahl, Trent C.; Krishnamurthy, Ramanarayan; Saleem, Fozia; Liu, Philip; Dame, Zerihun T.; Poelzer, Jenna; Huynh, Jessica; Yallou, Faizath S.; Psychogios, Nick; Dong, Edison; Bogumil, Ralf; Roehring, Cornelia; Wishart, David S. (Public Library of Science, 2013)
      Urine has long been a “favored” biofluid among metabolomics researchers. It is sterile, easy-to-obtain in large volumes, largely free from interfering proteins or lipids and chemically complex. However, this chemical ...

    • The Microbial Spectrum of Neonatal Sepsis in Uganda: Recovery of Culturable Bacteria in Mother-Infant Pairs 

      Kiwanuka, Julius; Bazira, Joel; Mwanga, Juliet; Tumusiime, Dickson; Nyesigire, Eunice; Lwanga, Nkangi; Warf, Benjamin C.; Kapur, Vivek; Poss, Mary; Schiff, Steven J. (Public Library of Science, 2013)
      Neonatal sepsis in the developing world is incompletely characterized. We seek to characterize the microbial spectrum involved in sepsis and determine the role of maternal transmission by comparing organisms that can be ...

    • Performance of the GeneXpert Ebola Assay for Diagnosis of Ebola Virus Disease in Sierra Leone: A Field Evaluation Study 

      Semper, Amanda E.; Broadhurst, M. Jana; Richards, Jade; Foster, Geraldine M.; Simpson, Andrew J. H.; Logue, Christopher H.; Kelly, J. Daniel; Miller, Ann; Brooks, Tim J. G.; Murray, Megan; Pollock, Nira R. (Public Library of Science, 2016)
      Background: Throughout the Ebola virus disease (EVD) epidemic in West Africa, field laboratory testing for EVD has relied on complex, multi-step real-time reverse transcription PCR (RT-PCR) assays; an accurate sample-to-answer ...

    • Relationship between C - Reactive Protein and Stroke: A Large Prospective Community Based Study 

      Liu, Yanfang; Wang, Jing; Zhang, Liqun; Wang, Chunxue; Wu, Jianwei; Zhou, Yong; Gao, Xiang; Wang, Anxin; Wu, Shouling; Zhao, Xingquan (Public Library of Science, 2014)
      Objective: Previous studies have suggested that C-reactive protein (CRP) was associated with risk of stroke. There were few studies in Asian population, or on stroke subtypes other than ischemic stroke. We thus investigated ...