Now showing items 1-13 of 13

    • Computer Aided Diagnosis for Confocal Laser Endomicroscopy in Advanced Colorectal Adenocarcinoma 

      Ştefănescu, Daniela; Streba, Costin; Cârţână, Elena Tatiana; Săftoiu, Adrian; Gruionu, Gabriel; Gruionu, Lucian Gheorghe (Public Library of Science, 2016)
      Introduction: Confocal laser endomicroscopy (CLE) is becoming a popular method for optical biopsy of digestive mucosa for both diagnostic and therapeutic procedures. Computer aided diagnosis of CLE images, using image ...
    • Confocal Laser Endomicroscopy for the Morphometric Evaluation of Microvessels in Human Colorectal Cancer Using Targeted Anti-CD31 Antibodies 

      Cârţână, Tatiana; Săftoiu, Adrian; Gruionu, Lucian Gheorghe; Gheonea, Dan Ionuţ; Pirici, Daniel; Georgescu, Claudia Valentina; Ciocâlteu, Adriana; Gruionu, Gabriel (Public Library of Science, 2012)
      Introduction: Numerous anti-angiogenic agents are currently developed to limit tumor growth and metastasis. While these drugs offer hope for cancer patients, their transient effect on tumor vasculature is difficult to ...
    • Evaluation of New Morphometric Parameters of Neoangiogenesis in Human Colorectal Cancer Using Confocal Laser Endomicroscopy (CLE) and Targeted Panendothelial Markers 

      Ciocâlteu, Adriana; Săftoiu, Adrian; Cârţână, Tatiana; Gruionu, Lucian Gheorghe; Pirici, Daniel; Georgescu, Corneliu Cristian; Georgescu, Claudia-Valentina; Gheonea, Dan Ionuţ; Gruionu, Gabriel (Public Library of Science, 2014)
      The tumor microcirculation is characterized by an abnormal vascular network with dilated, tortuous and saccular vessels. Therefore, imaging the tumor vasculature and determining its morphometric characteristics represent ...
    • Fc-Epsilon-RI, the High Affinity IgE-Receptor, Is Robustly Expressed in the Upper Gastrointestinal Tract and Modulated by Mucosal Inflammation 

      Bannert, Christina; Bidmon-Fliegenschnee, Bettina; Stary, Georg; Hotzy, Florian; Stift, Judith; Nurko, Samuel; Szépfalusi, Zsolt; Fiebiger, Edda; Dehlink, Eleonora (Public Library of Science, 2012)
      Background: The role of the high affinity IgE receptor, FcεRI, in IgE-mediated immune responses of the gastrointestinal (GI) mucosa is poorly understood. Currently, a detailed characterization of FcεRI expression throughout ...
    • Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer 

      Gong, Jian; Hutter, Carolyn M.; Newcomb, Polly A.; Ulrich, Cornelia M.; Bien, Stephanie A.; Campbell, Peter T.; Baron, John A.; Berndt, Sonja I.; Bezieau, Stephane; Brenner, Hermann; Casey, Graham; Chan, Andrew T.; Chang-Claude, Jenny; Du, Mengmeng; Duggan, David; Figueiredo, Jane C.; Gallinger, Steven; Giovannucci, Edward L.; Haile, Robert W.; Harrison, Tabitha A.; Hayes, Richard B.; Hoffmeister, Michael; Hopper, John L.; Hudson, Thomas J.; Jeon, Jihyoun; Jenkins, Mark A.; Kocarnik, Jonathan; Küry, Sébastien; Le Marchand, Loic; Lin, Yi; Lindor, Noralane M.; Nishihara, Reiko; Ogino, Shuji; Potter, John D.; Rudolph, Anja; Schoen, Robert E.; Schrotz-King, Petra; Seminara, Daniela; Slattery, Martha L.; Thibodeau, Stephen N.; Thornquist, Mark; Toth, Reka; Wallace, Robert; White, Emily; Jiao, Shuo; Lemire, Mathieu; Hsu, Li; Peters, Ulrike (Public Library of Science, 2016)
      Genome-wide association studies (GWAS) have identified many genetic susceptibility loci for colorectal cancer (CRC). However, variants in these loci explain only a small proportion of familial aggregation, and there are ...
    • Genotype Directed Therapy in Murine Mismatch Repair Deficient Tumors 

      Kucherlapati, Melanie H.; Esfahani, Shadi; Habibollahi, Peiman; Wang, Junning; Still, Eric R.; Bronson, Roderick T.; Mahmood, Umar; Kucherlapati, Raju S. (Public Library of Science, 2013)
      The PI3K/AKT/mTOR pathway has frequently been found activated in human tumors. We show that in addition to Wnt signaling dysfunction, the PI3K/AKT/mTOR pathway is often upregulated in mouse Msh2−/− initiated intestinal ...
    • In vitro evaluation of bi-layer silk fibroin scaffolds for gastrointestinal tissue engineering 

      Franck, Debra; Chung, Yeun Goo; Coburn, Jeannine; Kaplan, David L; Estrada, Carlos R; Mauney, Joshua R (SAGE Publications, 2014)
      Silk fibroin scaffolds were investigated for their ability to support attachment, proliferation, and differentiation of human gastrointestinal epithelial and smooth muscle cell lines in order to ascertain their potential ...
    • Inferring Dynamic Signatures of Microbes in Complex Host Ecosystems 

      Gerber, Georg Kurt; Onderdonk, Andrew Bruce; Bry, Lynn (Public Library of Science, 2012)
      The human gut microbiota comprise a complex and dynamic ecosystem that profoundly affects host development and physiology. Standard approaches for analyzing time-series data of the microbiota involve computation of measures ...
    • Pre-Diagnostic Leukocyte Genomic DNA Methylation and the Risk of Colorectal Cancer in Women 

      Nan, Hongmei; Giovannucci, Edward L.; Wu, Kana; Selhub, Jacob; Paul, Ligi; Rosner, Bernard Alfred; Fuchs, Charles Stewart; Cho, Eunyoung (Public Library of Science, 2013)
      Background: Abnormal one-carbon metabolism may lead to general genomic (global) hypomethylation, which may predispose an individual to the development of colorectal neoplasia. Methods: We evaluated the association between ...
    • PTGER4 Expression-Modulating Polymorphisms in the 5p13.1 Region Predispose to Crohn's Disease and Affect NF-κB and XBP1 Binding Sites 

      Glas, Jürgen; Seiderer, Julia; Czamara, Darina; Pasciuto, Giulia; Diegelmann, Julia; Wetzke, Martin; Olszak, Torsten; Wolf, Christiane; Müller-Myhsok, Bertram; Balschun, Tobias; Achkar, Jean-Paul; Kamboh, M. Ilyas; Franke, Andre; Duerr, Richard H.; Brand, Stephan (Public Library of Science, 2012)
      Background: Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort ...
    • Purinergic Signaling as a Regulator of Th17 Cell Plasticity 

      Fernández, Dominique; Flores-Santibáñez, Felipe; Neira, Jocelyn; Osorio-Barrios, Francisco; Tejón, Gabriela; Nuñez, Sarah; Hidalgo, Yessia; Fuenzalida, Maria Jose; Meza, Daniel; Ureta, Gonzalo; Lladser, Alvaro; Pacheco, Rodrigo; Acuña-Castillo, Claudio; Guixé, Victoria; Quintana, Francisco J.; Bono, Maria Rosa; Rosemblatt, Mario; Sauma, Daniela (Public Library of Science, 2016)
      T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving ...
    • Reduced Intestinal Tumorigenesis in APCmin Mice Lacking Melanin-Concentrating Hormone 

      Nagel, Jutta M.; Geiger, Brenda Mae; Karagiannis, Apostolos K. A.; Gras-Miralles, Beatriz; Horst, David; Najarian, Robert; Ziogas, Dimitrios C.; Chen, Xinhua; Kokkotou, Efi G. (Public Library of Science, 2012)
      Background: Melanin-concentrating hormone (MCH) is an evolutionary conserved hypothalamic neuropeptide that in mammals primarily regulates appetite and energy balance. We have recently identified a novel role for MCH in ...
    • γ-Tocotrienol Induces Paraptosis-Like Cell Death in Human Colon Carcinoma SW620 Cells 

      Zhang, Jing-Shu; Li, Da-Ming; Ma, Yue; He, Ning; Gu, Qing; Wang, Feng-Shan; Jiang, Shu-Qing; Chen, Bing-Qing; Liu, Jia-Ren (Public Library of Science, 2013)
      Colorectal cancer is one of the most serious illnesses among diagnosed cancer. As a new type of anti-cancer composition from tocotrienol-rich fraction of palm oil, γ-tocotrienol is widely used in anti-cancer research. The ...