Browsing HMS Scholarly Articles by Keyword "Dementia"

Now showing items 1-20 of 29

    • Anesthetic Isoflurane Increases Phosphorylated Tau Levels Mediated by Caspase Activation and Aβ Generation 

      Dong, Yuanlin; Xu, Zhipeng; Wu, Xu; Zhang, Yiying; Xie, Zhongcong (Public Library of Science, 2012)
      Anesthetic isoflurane has been shown to promote Alzheimer’s disease (AD) neuropathogenesis by inducing caspase activation and accumulation of β-amyloid (Aβ). Phosphorylation of tau protein is another important feature of ...

    • Assessing Error Awareness as a Mediator of the Relationship between Subjective Concerns and Cognitive Performance in Older Adults 

      Buckley, Rachel F.; Laming, Gemma; Chen, Li Peng Evelyn; Crole, Alice; Hester, Robert (Public Library of Science, 2016)
      Objectives: Subjective concerns of cognitive decline (SCD) often manifest in older adults who exhibit objectively normal cognitive functioning. This subjective-objective discrepancy is counter-intuitive when mounting ...

    • Association between Amylin and Amyloid-β Peptides in Plasma in the Context of Apolipoprotein E4 Allele 

      Qiu, Wei Qiao; Wallack, Max; Dean, Michael; Liebson, Elizabeth; Mwamburi, Mkaya; Zhu, Haihao (Public Library of Science, 2014)
      Amylin, a pancreatic peptide that readily crosses the blood brain barrier (BBB), and amyloid-beta peptide (Aβ), the main component of amyloid plaques and a major component of Alzheimer's disease (AD) pathology in the brain, ...

    • Body Mass Index and Decline of Cognitive Function 

      Kim, Sujin; Kim, Yongjoo; Park, Sang Min (Public Library of Science, 2016)
      Background: The association between body mass index (BMI) and cognitive function is a public health issue. This study investigated the relationship between obesity and cognitive impairment which was assessed by the Korean ...

    • Calibration and Validation of an Innovative Approach for Estimating General Cognitive Performance 

      Gross, Alden L.; Jones, Richard Norman; Fong, Tamara G; Tommet, Douglas; Inouye, Sharon (S. Karger AG, 2014)
      Objective: To evaluate a new approach for creating a composite measure of cognitive function, we calibrated a measure of general cognitive performance from existing neuropsychological batteries. Methods: We applied our ...

    • A call for comparative effectiveness research to learn whether routine clinical care decisions can protect from dementia and cognitive decline 

      Dacks, Penny A.; Armstrong, Joshua J.; Brannan, Stephen K.; Carman, Aaron J.; Green, Allan M.; Kirkman, M. Sue; Krakoff, Lawrence R.; Kuller, Lewis H.; Launer, Lenore J.; Lovestone, Simon; Merikle, Elizabeth; Neumann, Peter J.; Rockwood, Kenneth; Shineman, Diana W.; Stefanacci, Richard G.; Velentgas, Priscilla; Viswanathan, Anand; Whitmer, Rachel A.; Williamson, Jeff D.; Fillit, Howard M. (BioMed Central, 2016)
      Common diseases like diabetes, hypertension, and atrial fibrillation are probable risk factors for dementia, suggesting that their treatments may influence the risk and rate of cognitive and functional decline. Moreover, ...

    • Cholinergic Deficiency Hypothesis in Delirium: A Synthesis of Current Evidence 

      Hshieh, Tammy Ting; Fong, Tamara G; Marcantonio, Edward Ralph; Inouye, Sharon (Oxford University Press (OUP), 2008)
      Deficits in cholinergic function have been postulated to cause delirium and cognitive decline. This review examines current understanding of the cholinergic deficiency hypothesis in delirium by synthesizing evidence on ...

    • Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury 

      McKee, Ann C.; Cantu, Robert C.; Nowinski, Christopher J.; Hedley-Whyte, E. Tessa; Gavett, Brandon E.; Budson, Andrew E.; Santini, Veronica E.; Lee, Hyo-Soon; Kubilus, Caroline A.; Stern, Robert A. (Oxford University Press (OUP), 2009)
      Since the 1920s, it has been known that the repetitive brain trauma associated with boxing may produce a progressive neurological deterioration, originally termed “dementia pugilistica” and more recently, chronic traumatic ...

    • Concordance between DSM-IV and DSM-5 criteria for delirium diagnosis in a pooled database of 768 prospectively evaluated patients using the delirium rating scale-revised-98 

      Meagher, David J; Morandi, Alessandro; Inouye, Sharon K; Ely, Wes; Adamis, Dimitrios; Maclullich, Alasdair J; Rudolph, James L; Neufeld, Karin; Leonard, Maeve; Bellelli, Giuseppe; Davis, Daniel; Teodorczuk, Andrew; Kreisel, Stefan; Thomas, Christine; Hasemann, Wolfgang; Timmons, Suzanne; O’Regan, Niamh; Grover, Sandeep; Jabbar, Faiza; Cullen, Walter; Dunne, Colum; Kamholz, Barbara; Van Munster, Barbara C; De Rooij, Sophia E; De Jonghe, Jos; Trzepacz, Paula T (BioMed Central, 2014)
      Background: The Diagnostic and Statistical Manual fifth edition (DSM-5) provides new criteria for delirium diagnosis. We examined delirium diagnosis using these new criteria compared with the Diagnostic and Statistical ...

    • Considering the base rates of low performance in cognitively healthy older adults improves the accuracy to identify neurocognitive impairment with the Consortium to Establish a Registry for Alzheimer’s Disease-Neuropsychological Assessment Battery (CERAD-NAB) 

      Mistridis, Panagiota; Egli, Simone C.; Iverson, Grant L.; Berres, Manfred; Willmes, Klaus; Welsh-Bohmer, Kathleen A.; Monsch, Andreas U. (Springer Berlin Heidelberg, 2015)
      It is common for some healthy older adults to obtain low test scores when a battery of neuropsychological tests is administered, which increases the risk of the clinician misdiagnosing cognitive impairment. Thus, base rates ...

    • Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research 

      Wray, Selina; Self, Matthew; Lewis, Patrick A.; Taanman, Jan-Willem; Ryan, Natalie S.; Mahoney, Colin J.; Liang, Yuying; Devine, Michael J.; Sheerin, Una-Marie; Houlden, Henry; Morris, Huw R.; Healy, Daniel; Marti-Masso, Jose-Felix; Preza, Elisavet; Barker, Suzanne; Sutherland, Margaret; Corriveau, Roderick A.; D'Andrea, Michael; Schapira, Anthony H. V.; Uitti, Ryan J.; Guttman, Mark; Opala, Grzegorz; Jasinska-Myga, Barbara; Puschmann, Andreas; Nilsson, Christer; Espay, Alberto J.; Slawek, Jaroslaw; Gutmann, Ludwig; Boeve, Bradley F.; Boylan, Kevin; Stoessl, A. Jon; Ross, Owen A.; Maragakis, Nicholas J.; Van Gerpen, Jay; Gerstenhaber, Melissa; Gwinn, Katrina; Dawson, Ted M.; Marder, Karen S.; Clark, Lorraine N.; Przedborski, Serge E.; Finkbeiner, Steven; Rothstein, Jeffrey D.; Wszolek, Zbigniew K.; Rossor, Martin N.; Hardy, John; Isacson, Ole Stefan (Public Library of Science, 2012)
      Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation ...

    • Galactic Cosmic Radiation Leads to Cognitive Impairment and Increased Aβ Plaque Accumulation in a Mouse Model of Alzheimer’s Disease 

      Cherry, Jonathan D.; Liu, Bin; Frost, Jeffrey L.; Lemere, Cynthia Ann; Williams, Jacqueline P.; Olschowka, John A.; O’Banion, M. Kerry (Public Library of Science, 2012)
      Galactic Cosmic Radiation consisting of high-energy, high-charged (HZE) particles poses a significant threat to future astronauts in deep space. Aside from cancer, concerns have been raised about late degenerative risks, ...

    • Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease 

      Escott-Price, Valentina; Bellenguez, Céline; Wang, Li-San; Choi, Seung-Hoan; Harold, Denise; Jones, Lesley; Holmans, Peter; Gerrish, Amy; Vedernikov, Alexey; Richards, Alexander; DeStefano, Anita L.; Lambert, Jean-Charles; Ibrahim-Verbaas, Carla A.; Naj, Adam C.; Sims, Rebecca; Jun, Gyungah; Bis, Joshua C.; Beecham, Gary W.; Grenier-Boley, Benjamin; Russo, Giancarlo; Thornton-Wells, Tricia A.; Denning, Nicola; Smith, Albert V.; Chouraki, Vincent; Thomas, Charlene; Ikram, M. Arfan; Zelenika, Diana; Vardarajan, Badri N.; Kamatani, Yoichiro; Lin, Chiao-Feng; Schmidt, Helena; Kunkle, Brian; Dunstan, Melanie L.; Vronskaya, Maria; Johnson, Andrew D.; Ruiz, Agustin; Bihoreau, Marie-Thérèse; Reitz, Christiane; Pasquier, Florence; Hollingworth, Paul; Hanon, Olivier; Fitzpatrick, Annette L.; Buxbaum, Joseph D.; Campion, Dominique; Crane, Paul K.; Baldwin, Clinton; Becker, Tim; Gudnason, Vilmundur; Cruchaga, Carlos; Craig, David; Amin, Najaf; Berr, Claudine; Lopez, Oscar L.; De Jager, Philip L.; Deramecourt, Vincent; Johnston, Janet A.; Evans, Denis; Lovestone, Simon; Letenneur, Luc; Hernández, Isabel; Rubinsztein, David C.; Eiriksdottir, Gudny; Sleegers, Kristel; Goate, Alison M.; Fiévet, Nathalie; Huentelman, Matthew J.; Gill, Michael; Brown, Kristelle; Kamboh, M. Ilyas; Keller, Lina; Barberger-Gateau, Pascale; McGuinness, Bernadette; Larson, Eric B.; Myers, Amanda J.; Dufouil, Carole; Todd, Stephen; Wallon, David; Love, Seth; Rogaeva, Ekaterina; Gallacher, John; George-Hyslop, Peter St; Clarimon, Jordi; Lleo, Alberto; Bayer, Anthony; Tsuang, Debby W.; Yu, Lei; Tsolaki, Magda; Bossù, Paola; Spalletta, Gianfranco; Proitsi, Petra; Collinge, John; Sorbi, Sandro; Garcia, Florentino Sanchez; Fox, Nick C.; Hardy, John; Naranjo, Maria Candida Deniz; Bosco, Paolo; Clarke, Robert; Brayne, Carol; Galimberti, Daniela; Scarpini, Elio; Bonuccelli, Ubaldo; Mancuso, Michelangelo; Siciliano, Gabriele; Moebus, Susanne; Mecocci, Patrizia; Zompo, Maria Del; Maier, Wolfgang; Hampel, Harald; Pilotto, Alberto; Frank-García, Ana; Panza, Francesco; Solfrizzi, Vincenzo; Caffarra, Paolo; Nacmias, Benedetta; Perry, William; Mayhaus, Manuel; Lannfelt, Lars; Hakonarson, Hakon; Pichler, Sabrina; Carrasquillo, Minerva M.; Ingelsson, Martin; Beekly, Duane; Alvarez, Victoria; Zou, Fanggeng; Valladares, Otto; Younkin, Steven G.; Coto, Eliecer; Hamilton-Nelson, Kara L.; Gu, Wei; Razquin, Cristina; Pastor, Pau; Mateo, Ignacio; Owen, Michael J.; Faber, Kelley M.; Jonsson, Palmi V.; Combarros, Onofre; O'Donovan, Michael C.; Cantwell, Laura B.; Soininen, Hilkka; Blacker, Deborah; Mead, Simon; Mosley, Thomas H.; Bennett, David A.; Harris, Tamara B.; Fratiglioni, Laura; Holmes, Clive; de Bruijn, Renee F. A. G.; Passmore, Peter; Montine, Thomas J.; Bettens, Karolien; Rotter, Jerome I.; Brice, Alexis; Morgan, Kevin; Foroud, Tatiana M.; Kukull, Walter A.; Hannequin, Didier; Powell, John F.; Nalls, Michael A.; Ritchie, Karen; Lunetta, Kathryn L.; Kauwe, John S. K.; Boerwinkle, Eric; Riemenschneider, Matthias; Boada, Mercè; Hiltunen, Mikko; Martin, Eden R.; Schmidt, Reinhold; Rujescu, Dan; Dartigues, Jean-François; Mayeux, Richard; Tzourio, Christophe; Hofman, Albert; Nöthen, Markus M.; Graff, Caroline; Psaty, Bruce M.; Haines, Jonathan L.; Lathrop, Mark; Pericak-Vance, Margaret A.; Launer, Lenore J.; Van Broeckhoven, Christine; Farrer, Lindsay A.; van Duijn, Cornelia M.; Ramirez, Alfredo; Seshadri, Sudha; Schellenberg, Gerard D.; Amouyel, Philippe; Williams, Julie (Public Library of Science, 2014)
      Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify ...

    • Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias 

      Beecham, Gary W.; Hamilton, Kara; Naj, Adam C.; Martin, Eden R.; Huentelman, Matt; Myers, Amanda J.; Corneveaux, Jason J.; Hardy, John; Vonsattel, Jean-Paul; Younkin, Steven G.; Bennett, David A.; De Jager, Philip L.; Larson, Eric B.; Crane, Paul K.; Kamboh, M. Ilyas; Kofler, Julia K.; Mash, Deborah C.; Duque, Linda; Gilbert, John R.; Gwirtsman, Harry; Buxbaum, Joseph D.; Kramer, Patricia; Dickson, Dennis W.; Farrer, Lindsay A.; Frosch, Matthew P.; Ghetti, Bernardino; Haines, Jonathan L.; Hyman, Bradley T.; Kukull, Walter A.; Mayeux, Richard P.; Pericak-Vance, Margaret A.; Schneider, Julie A.; Trojanowski, John Q.; Reiman, Eric M.; Schellenberg, Gerard D.; Montine, Thomas J. (Public Library of Science, 2014)
      Alzheimer's disease (AD) and related dementias are a major public health challenge and present a therapeutic imperative for which we need additional insight into molecular pathogenesis. We performed a genome-wide association ...

    • In the Information Age, do dementia caregivers get the information they need? Semi-structured interviews to determine informal caregivers’ education needs, barriers, and preferences 

      Peterson, Kendra; Hahn, Howard; Lee, Amber J.; Madison, Catherine A.; Atri, Alireza (BioMed Central, 2016)
      Background: Most patients with dementia or cognitive impairment receive care from family members, often untrained for this challenging role. Caregivers may not access publicly available caregiving information, and caregiver ...

    • In Vivo Detection of Amyloid-\(\beta\) Deposits Using Heavy Chain Antibody Fragments in a Transgenic Mouse Model for Alzheimer's Disease 

      Nabuurs, Rob J. A.; Rutgers, Kim S.; Welling, Mick M.; Metaxas, Athanasios; de Backer, Maaike E.; Rotman, Maarten; Bacskai, Brian; van Buchem, Mark A.; van der Maarel, Silvère M.; van der Weerd, Louise (Public Library of Science, 2012)
      This study investigated the in vivo properties of two heavy chain antibody fragments (V\(_H\)H), ni3A and pa2H, to differentially detect vascular or parenchymal amyloid-\(\beta\) deposits characteristic for Alzheimer's ...

    • Longitudinal Changes in White Matter Tract Integrity across the Adult Lifespan and Its Relation to Cortical Thinning 

      Storsve, Andreas B.; Fjell, Anders M.; Yendiki, Anastasia; Walhovd, Kristine B. (Public Library of Science, 2016)
      A causal link between decreases in white matter (WM) integrity and cortical degeneration is assumed, but there is scarce knowledge on the relationship between these changes across the adult human lifespan. We investigated ...

    • A Machine Learning Approach for Identifying Amino Acid Signatures in the HIV Env Gene Predictive of Dementia 

      Holman, Alexander G.; Gabuzda, Dana Helga (Public Library of Science, 2012)
      The identification of nucleotide sequence variations in viral pathogens linked to disease and clinical outcomes is important for developing vaccines and therapies. However, identifying these genetic variations in rapidly ...

    • Methodology for developing quality indicators for the care of older people in the Emergency Department 

      Martin-Khan, Melinda; Burkett, Ellen; Schnitker, Linda; Jones, Richard N; Gray, Leonard C (BioMed Central, 2013)
      Background: Compared with younger people, older people have a higher risk of adverse health outcomes when presenting to emergency departments. As the population ages, older people will make up an increasing proportion of ...

    • NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies 

      Ali, Yousuf O.; Allen, Hunter M.; Yu, Lei; Li-Kroeger, David; Bakhshizadehmahmoudi, Dena; Hatcher, Asante; McCabe, Cristin; Xu, Jishu; Bjorklund, Nicole; Taglialatela, Giulio; Bennett, David A.; De Jager, Philip L.; Shulman, Joshua M.; Bellen, Hugo J.; Lu, Hui-Chen (Public Library of Science, 2016)
      Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in numerous preclinical models of neurodegeneration. Here, we show that brain nmnat2 mRNA levels correlate positively with global cognitive ...