Browsing HMS Scholarly Articles by Keyword "Diabetes Mellitus Type 1"

Now showing items 1-9 of 9

    • IL-1\(\beta\) Is Upregulated in the Diabetic Retina and Retinal Vessels: Cell-Specific Effect of High Glucose and IL-1\(\beta\) Autostimulation 

      Liu, Yang; Biarnés Costa, Montserrat; Gerhardinger, Chiara (Public Library of Science, 2012)
      Many molecular and cellular abnormalities detected in the diabetic retina support a role for IL-1\(\beta\)-driven neuroinflammation in the pathogenesis of diabetic retinopathy. IL-1\(\beta\) is well known for its role in ...

    • Increasing Glucose 6-Phosphate Dehydrogenase Activity Restores Redox Balance in Vascular Endothelial Cells Exposed to High Glucose 

      Zhang, Zhaoyun; Yang, Zhihong; Zhu, Bo; Hu, Ji; Liew, Chong-Wee; Leopold, Jane Anne; Handy, Diane Elizabeth; Loscalzo, Joseph; Stanton, Robert Carl; Zhang, Ying-Yi (Public Library of Science, 2012)
      Previous studies have shown that high glucose increases reactive oxygen species (ROS) in endothelial cells that contributes to vascular dysfunction and atherosclerosis. Accumulation of ROS is due to dysregulated redox ...

    • The Islet Estrogen Receptor-α Is Induced by Hyperglycemia and Protects Against Oxidative Stress-Induced Insulin-Deficient Diabetes 

      Kilic, Gamze; Alvarez-Mercado, Ana I.; Zarrouki, Bader; Opland, Darren; Liew, Chong Wee; Alonso, Laura C.; Myers, Martin G.; Jonas, Jean-Christophe; Poitout, Vincent; Kulkarni, Rohit N.; Mauvais-Jarvis, Franck (Public Library of Science, 2014)
      The female steroid, 17β-estradiol (E2), is important for pancreatic β-cell function and acts via at least three estrogen receptors (ER), ERα, ERβ, and the G-protein coupled ER (GPER). Using a pancreas-specific ERα knockout ...

    • Network-Level Structural Abnormalities of Cerebral Cortex in Type 1 Diabetes Mellitus 

      Lyoo, In Kyoon; Yoon, Sujung; Renshaw, Perry F.; Hwang, Jaeuk; Bae, Sujin; Musen, Gail; Kim, Jieun E.; Bolo, Nicolas; Jeong, Hyeonseok S.; Simonson, Donald C.; Lee, Sun Hea; Weinger, Katie; Jung, Jiyoung J.; Ryan, Christopher M.; Choi, Yera; Jacobson, Alan M. (Public Library of Science, 2013)
      Type 1 diabetes mellitus (T1DM) usually begins in childhood and adolescence and causes lifelong damage to several major organs including the brain. Despite increasing evidence of T1DM-induced structural deficits in cortical ...

    • New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes 

      Sandholm, Niina; Salem, Rany M.; McKnight, Amy Jayne; Brennan, Eoin P.; Forsblom, Carol; Isakova, Tamara; McKay, Gareth J.; Williams, Winfred Woodrow; Sadlier, Denise M.; Mäkinen, Ville-Petteri; Swan, Elizabeth J.; Palmer, Cameron Douglas; Boright, Andrew P.; Ahlqvist, Emma; Deshmukh, Harshal A.; Keller, Benjamin J.; Huang, Huateng; Ahola, Aila J.; Fagerholm, Emma; Gordin, Daniel; Harjutsalo, Valma; He, Bing; Heikkilä, Outi; Hietala, Kustaa; Kytö, Janne; Lahermo, Päivi; Lehto, Markku; Lithovius, Raija; Österholm, Anne-May; Parkkonen, Maija; Pitkäniemi, Janne; Rosengård-Bärlund, Milla; Saraheimo, Markku; Sarti, Cinzia; Söderlund, Jenny; Soro-Paavonen, Aino; Syreeni, Anna; Thorn, Lena M.; Tikkanen, Heikki; Tolonen, Nina; Tryggvason, Karl; Tuomilehto, Jaakko; Wadén, Johan; Gill, Geoffrey V.; Prior, Sarah Virginie; Guiducci, Candace; Mirel, Daniel B.; Taylor, Andrew; Hosseini, S. Mohsen; Parving, Hans-Henrik; Rossing, Peter; Tarnow, Lise; Ladenvall, Claes; Alhenc-Gelas, François; Lefebvre, Pierre; Rigalleau, Vincent; Roussel, Ronan; Tregouet, David-Alexandre; Maestroni, Anna; Maestroni, Silvia; Falhammar, Henrik; Gu, Tianwei; Möllsten, Anna; Cimponeriu, Danut; Ioana, Mihai; Mota, Maria; Mota, Eugen; Serafinceanu, Cristian; Stavarachi, Monica; Hanson, Robert L.; Nelson, Robert G.; Kretzler, Matthias; Colhoun, Helen M.; Panduru, Nicolae Mircea; Gu, Harvest F.; Brismar, Kerstin; Zerbini, Gianpaolo; Hadjadj, Samy; Marre, Michel; Groop, Leif; Lajer, Maria; Bull, Shelley B.; Waggott, Daryl; Paterson, Andrew D.; Savage, David A.; Bain, Stephen C.; Martin, Finian; Hirschhorn, Joel Naom; Godson, Catherine; Florez, Jose Carlos; Groop, Per-Henrik; Maxwell, Alexander P. (Public Library of Science, 2012)
      Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or kidney transplantation. In addition to ...

    • NKT Cells Stimulated by Long Fatty Acyl Chain Sulfatides Significantly Reduces the Incidence of Type 1 Diabetes in Nonobese Diabetic Mice 

      Subramanian, Lakshmimathy; Blumenfeld, Hartley; Tohn, Robert; Ly, Dalam; Aguilera, Carlos; Maricic, Igor; Mansson, Jan-Eric; Buschard, Karsten; Kumar, Vipin; Delovitch, Terry L. (Public Library of Science, 2012)
      Sulfatide-reactive type II NKT cells have been shown to regulate autoimmunity and anti-tumor immunity. Although, two major isoforms of sulfatide, C16:0 and C24:0, are enriched in the pancreas, their relative role in ...

    • Proof-of-Concept, Randomized, Controlled Clinical Trial of Bacillus-Calmette-Guerin for Treatment of Long-Term Type 1 Diabetes 

      Faustman, Denise Louise; Wang, Limei; Okubo, Yoshiaki; Burger, Douglas E.; Ban, Liqin; Man, Guotong; Zheng, Hui; Schoenfeld, David Alan; Pompei, Richard; Avruch, Joseph; Nathan, David Matthew (Public Library of Science, 2012)
      Background: No targeted immunotherapies reverse type 1 diabetes in humans. However, in a rodent model of type 1 diabetes, Bacillus Calmette-Guerin (BCG) reverses disease by restoring insulin secretion. Specifically, it ...

    • The Role of TNF-\(\alpha\) in Mice with Type 1- and 2- Diabetes 

      Bhasin, Manoj; Awdeh, Zuheir; Qipo, Andi; Putheti, Prabhakar; Shi, Hang; Csizuadia, Eva; Koulmanda, Maria; Fan, Zhigang; Hanidziar, Dusan; Libermann, Towia Aron; Strom, Terry Barton (Public Library of Science, 2012)
      Background: Previously, we have demonstrated that short-term treatment of new onset diabetic Non-obese diabetic (NOD) mice, mice that are afflicted with both type 1 (T1D) and type 2 (T2D) diabetes with either Power Mix ...

    • Transcriptome Analysis of Proximal Tubular Cells (HK-2) Exposed to Urines of Type 1 Diabetes Patients at Risk of Early Progressive Renal Function Decline 

      Wanic, Krzysztof; Krolewski, Bozena Krystyna; Ju, Wenjun; Placha, Grzegorz; Niewczas, Monika Anna; Walker, William; Warram, James H.; Kretzler, Matthias; Krolewski, Andrzej Stefan (Public Library of Science, 2013)
      Background: In patients with Type 1 Diabetes (T1D) who develop microalbuminuria, progressive decline in glomerular filtration rate (GFR) may be initiated by leakage into the urine of toxic proteins (txUPs). This study ...