Browsing HMS Scholarly Articles by Keyword "Nanotechnology"

Now showing items 1-12 of 12

    • Binary DNA Nanostructures for Data Encryption 

      Halvorsen, Kenneth A; Wong, Wesley Philip (Public Library of Science, 2012)
      We present a simple and secure system for encrypting and decrypting information using DNA self-assembly. Binary data is encoded in the geometry of DNA nanostructures with two distinct conformations. Removing or leaving out ...

    • ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation 

      Wang, Andrew Z; Yuet, Kai; Zhang, Liangfang; Gu, Frank X; Huynh-Le, Minh; Radovic-Moreno, Aleksandar F; Kantoff, Philip Wayne; Bander, Neil H; Langer, Robert S.; Farokhzad, Omid Cameron (Future Medicine Ltd, 2010)
      Aim: The development of chemoradiation – the concurrent administration of chemotherapy and radiotherapy – has led to significant improvements in local tumor control and survival. However, it is limited by its high toxicity. ...

    • Emerging nanotechnology approaches for HIV/AIDS treatment and prevention 

      Mamo, Tewodros; Moseman, E Ashley; Kolishetti, Nagesh; Salvador-Morales, Carolina; Shi, Jinjun; Kuritzkes, Daniel Robert; Langer, Robert S.; Andrian, Ulrich von; Farokhzad, Omid Cameron (Future Medicine Ltd, 2010)
      Currently, there is no cure and no preventive vaccine for HIV/AIDS. Combination antiretroviral therapy has dramatically improved treatment, but it has to be taken for a lifetime, has major side effects and is ineffective ...

    • Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine 

      Zhang, Xue-Qing; Xu, Xiaoyang; Bertrand, Nicolas; Pridgen, Eric; Swami, Archana; Farokhzad, Omid Cameron (Elsevier BV, 2012)
      The application of nanotechnology to personalized medicine provides an unprecedented opportunity to improve the treatment of many diseases. Nanomaterials offer several advantages as therapeutic and diagnostic tools due to ...

    • Measuring Cation Dependent DNA Polymerase Fidelity Landscapes by Deep Sequencing 

      Zamft, Bradley; Marblestone, Adam Henry; Kording, Konrad; Schmidt, Daniel; Martin-Alarcon, Daniel; Tyo, Keith; Boyden, Edward S.; Church, George McDonald (Public Library of Science, 2012)
      High-throughput recording of signals embedded within inaccessible micro-environments is a technological challenge. The ideal recording device would be a nanoscale machine capable of quantitatively transducing a wide range ...

    • Metallized DNA nanolithography for encoding and transferring spatial information for graphene patterning 

      Jin, Zhong; Sun, Wei; Ke, Yonggang; Shih, Chih-Jen; Paulus, Geraldine Laura Caroline; Hua Wang, Qing; Mu, Bin; Yin, Peng; Strano, Michael S. (Springer Nature, 2013)
      The vision for graphene and other two-dimensional electronics is the direct production of nanoelectronic circuits and barrier materials from a single precursor sheet. DNA origami and single-stranded tiles are powerful ...

    • Molecular Threading: Mechanical Extraction, Stretching and Placement of DNA Molecules from a Liquid-Air Interface 

      Payne, Andrew C.; Andregg, Michael; Kemmish, Kent; Hamalainen, Mark; Bowell, Charlotte; Bleloch, Andrew; Klejwa, Nathan; Lehrach, Wolfgang; Schatz, Ken; Stark, Heather; Marblestone, Adam; Church, George; Own, Christopher S.; Andregg, William (Public Library of Science, 2013)
      We present “molecular threading”, a surface independent tip-based method for stretching and depositing single and double-stranded DNA molecules. DNA is stretched into air at a liquid-air interface, and can be subsequently ...

    • Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications 

      Shi, Jinjun; Votruba, Alexander R.; Farokhzad, Omid; Langer, Robert S. (American Chemical Society (ACS), 2010-09-08)
      The application of nanotechnology in medicine, referred to as nanomedicine, is offering numerous exciting possibilities in healthcare. Herein, we discuss two important aspects of nanomedicine—drug delivery and tissue ...

    • New Clathrin-Based Nanoplatforms for Magnetic Resonance Imaging 

      Vitaliano, Franco; Vitaliano, Gordana Dragan; Rios, Jose D.; Renshaw, Perry Franklin; Teicher, Martin Hersch (Public Library of Science, 2012)
      Background: Magnetic Resonance Imaging (MRI) has high spatial resolution, but low sensitivity for visualization of molecular targets in the central nervous system (CNS). Our goal was to develop a new MRI method with the ...

    • Novel 5′ Untranslated Region Directed Blockers of Iron-Regulatory Protein-1 Dependent Amyloid Precursor Protein Translation: Implications for Down Syndrome and Alzheimer's Disease 

      Bandyopadhyay, Sanghamitra; Cahill, Catherine; Balleidier, Amelie; Huang, Conan; Lahiri, Debomoy K.; Huang, Xudong; Rogers, Jack T. (Public Library of Science, 2013)
      We reported that iron influx drives the translational expression of the neuronal amyloid precursor protein (APP), which has a role in iron efflux. This is via a classic release of repressor interaction of APP mRNA with ...

    • A Novel Implantable Glaucoma Valve Using Ferrofluid 

      Paschalis, Eleftherios I.; Chodosh, James; Sperling, Ralph A.; Salvador-Culla, Borja; Dohlman, Claes (Public Library of Science, 2013)
      Purpose To present a novel design of an implantable glaucoma valve based on ferrofluidic nanoparticles and to compare it with a well-established FDA approved valve. Setting: Massachusetts Eye & Ear Infirmary, Boston, USA. ...

    • Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells 

      Tan, Aaron; Farhatnia, Yasmin; Goh, Debbie; Natasha, G; de Mel, Achala; Lim, Jing; Teoh, Swee-Hin; Malkovskiy, Andrey V; Chawla, Reema; Rajadas, Jayakumar; Cousins, Brian G; Hamblin, Michael R; Alavijeh, Mohammad S; Seifalian, Alexander M (2013)
      An unmet need exists for the development of next-generation multifunctional nanocomposite materials for biomedical applications, particularly in the field of cardiovascular regenerative biology. Herein, we describe the ...