Browsing HMS Scholarly Articles by Keyword "adeno-associated virus"
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Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter
(Blackwell Publishing Ltd, 2014)In this report, we describe the development of a modified adeno-associated virus (AAV) capsid and promoter for transduction of retinal ON-bipolar cells. The bipolar cells, which are post-synaptic to the photoreceptors, are ... -
How genetically engineered systems are helping to define, and in some cases redefine, the neurobiological basis of sleep and wake
(Taylor & Francis, 2015)The advent of genetically engineered systems, including transgenic animals and recombinant viral vectors, has facilitated a more detailed understanding of the molecular and cellular substrates regulating brain function. ...