Browsing HMS Scholarly Articles by Keyword "bacterial pathogens"
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Inflammation and Disintegration of Intestinal Villi in an Experimental Model for \(Vibrio\) \(parahaemolyticus\)-Induced Diarrhea
(Public Library of Science, 2012)\(Vibrio\) \(parahaemolyticus\) is a leading cause of seafood-borne gastroenteritis in many parts of the world, but there is limited knowledge of the pathogenesis of \(V.\) \(parahaemolyticus\)-induced diarrhea. The absence ... -
A Metalloproteinase Secreted by Streptococcus pneumoniae Removes Membrane Mucin MUC16 from the Epithelial Glycocalyx Barrier
(Public Library of Science, 2012)The majority of bacterial infections occur across wet-surfaced mucosal epithelia, including those that cover the eye, respiratory tract, gastrointestinal tract and genitourinary tract. The apical surface of all these mucosal ... -
Nod2 Suppresses Borrelia burgdorferi Mediated Murine Lyme Arthritis and Carditis Through the Induction of Tolerance
(Public Library of Science, 2011)The internalization of Borrelia burgdorferi, the causative agent of Lyme disease, by phagocytes is essential for an effective activation of the immune response to this pathogen. The intracellular, cytosolic receptor Nod2 ... -
The Regulatory Repertoire of Pseudomonas aeruginosa AmpC ß-Lactamase Regulator AmpR Includes Virulence Genes
(Public Library of Science, 2012)In Enterobacteriaceae, the transcriptional regulator AmpR, a member of the LysR family, regulates the expression of a chromosomal β-lactamase AmpC. The regulatory repertoire of AmpR is broader in Pseudomonas aeruginosa, ... -
Structural Basis for Type VI Secretion Effector Recognition by a Cognate Immunity Protein
(Public Library of Science, 2012)The type VI secretion system (T6SS) has emerged as an important mediator of interbacterial interactions. A T6SS from Pseudomonas aeruginosa targets at least three effector proteins, \(\underline t\)ype VI \(\underline ...