Browsing HMS Scholarly Articles by Keyword "bortezomib"

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    • Front Line Treatment of Elderly Multiple Myeloma in the Era of Novel Agents 

      Venon, Marie-Dominique; Roccaro, Aldo M.; Gay, Julie; Moreau, Anne-Sophie; Dulery, Remy; Facon, Thierry; Ghobrial, Irene; Leleu, Xavier (Dove Medical Press, 2009)
      Melphalan combined with prednisone (MP) has long been the historical treatment of reference for a large proportion of elderly myeloma (MM) patients ineligible for autologous stem cell transplantation, and is still the ...

    • miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1 

      Amodio, N; Di Martino, M T; Foresta, U; Leone, E; Lionetti, M; Leotta, M; Gullà, A M; Pitari, M R; Conforti, F; Rossi, M; Agosti, V; Fulciniti, M; Misso, G; Morabito, F; Ferrarini, M; Neri, A; Caraglia, M; Munshi, N C; Anderson, Kenneth Carl; Tagliaferri, P; Tassone, P (Nature Publishing Group, 2012)
      MicroRNAs (miRNAs) with tumor-suppressor potential might have therapeutic applications in multiple myeloma (MM) through the modulation of still undiscovered molecular pathways. Here, we investigated the effects of enforced ...