Now showing items 1-3 of 3

    • Catastrophic NAD+ Depletion in Activated T Lymphocytes Through Nampt Inhibition Reduces Demyelination and Disability in EAE 

      Bruzzone, Santina; Fruscione, Floriana; Morando, Sara; Ferrando, Tiziana; Poggi, Alessandro; Garuti, Anna; D'Urso, Agustina; Selmo, Martina; Benvenuto, Federica; Cea, Michele; Zoppoli, Gabriele; Moran, Eva; Soncini, Debora; Ballestrero, Alberto; Sordat, Bernard; Patrone, Franco; Uccelli, Antonio; Nencioni, Alessio; Mostoslavsky, Raul (Public Library of Science, 2009)
      Nicotinamide phosphoribosyltransferase (Nampt) inhibitors such as FK866 are potent inhibitors of NAD+ synthesis that show promise for the treatment of different forms of cancer. Based on Nampt upregulation in activated T ...
    • Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells 

      Cheng, Gang; Tse, Janet; Jain, Rakesh K.; Munn, Lance Leon (Public Library of Science, 2009)
      Background: Compressive mechanical stress produced during growth in a confining matrix limits the size of tumor spheroids, but little is known about the dynamics of stress accumulation, how the stress affects cancer cell ...
    • Pyrin Modulates the Intracellular Distribution of PSTPIP1 

      Waite, Andrea L.; Schaner, Philip; Richards, Neil; Balci-Peynircioglu, Banu; Masters, Seth L.; Brydges, Susannah D.; Hong, Arthur; Yilmaz, Engin; Kastner, Daniel L.; Gumucio, Deborah L.; May, Robin Charles; Fox, Michelle; Reinherz, Ellis Leonard (Public Library of Science, 2009)
      PSTPIP1 is a cytoskeleton-associated adaptor protein that links PEST-type phosphatases to their substrates. Mutations in PSTPIP1 cause PAPA syndrome (Pyogenic sterile Arthritis, Pyoderma gangrenosum, and Acne), an ...