Now showing items 1-11 of 11

    • The Acid Test of Fluoride: How pH Modulates Toxicity 

      Sharma, Ramaswamy Narayanaswamy; Tsuchiya, Masahiro; Skobe, Ziedonis; Tannous, Bakhos A.; Bartlett, John D. (Public Library of Science, 2010)
      Background: It is not known why the ameloblasts responsible for dental enamel formation are uniquely sensitive to fluoride (\(F^−\)). Herein, we present a novel theory with supporting data to show that the low pH environment ...
    • Characterization of Age-Dependent and Progressive Cortical Neuronal Degeneration in Presenilin Conditional Mutant Mice 

      Wines-Samuelson, Mary; Schulte, Eva C.; Smith, Miriam J.; Aoki, Chiye; Liu, Xinran; Cookson, Mark R.; Kelleher, Raymond J.; Shen, Jie (Public Library of Science, 2010)
      Presenilins are the major causative genes of familial Alzheimer's disease (AD). Our previous study has demonstrated essential roles of presenilins in memory and neuronal survival. Here, we explore further how loss of ...
    • Egr-1 Regulates Autophagy in Cigarette Smoke-induced Chronic Obstructive Pulmonary Disease 

      Chen, Zhi-Hua; Kim, Hong Pyo; Sciurba, Frank C.; Feghali-Bostwick, Carol; Stolz, Donna B.; Dhir, Rajiv; Landreneau, Rodney J.; Schuchert, Mathew J.; Yousem, Samuel A.; Pilewski, Joseph M.; Lee, Janet S.; Zhang, Yingze; Lee, Seon-Jin; Nakahira, Kiichi; Ryter, Stefan W.; Choi, Augustine M.K. (Public Library of Science, 2008)
      Background: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow limitation. Autophagy is ...
    • Induction of Erythroid Differentiation in Human Erythroleukemia Cells by Depletion of Malic Enzyme 2 

      Everett, Peter; Clish, Clary B.; Polymenis, Michael; Ren, Jian-Guo; Seth, Pankaj; Sukhatme, Vikas Pandurang (Public Library of Science, 2010)
      Malic enzyme 2 (ME2) is a mitochondrial enzyme that catalyzes the conversion of malate to pyruvate and CO2 and uses NAD as a cofactor. Higher expression of this enzyme correlates with the degree of cell de-differentiation. ...
    • Insulin Signaling Regulates Mitochondrial Function in Pancreatic β-Cells 

      Liu, Siming; Okada, Terumasa; Assmann, Anke; Soto, Jamie; Liew, Chong-Wee; Bugger, Heiko; Shirihai, Orian S.; Abel, E. Dale; Kulkarni, Rohit Narayan (Public Library of Science, 2009)
      Insulin/IGF-I signaling regulates the metabolism of most mammalian tissues including pancreatic islets. To dissect the mechanisms linking insulin signaling with mitochondrial function, we first identified a mitochondria-tethering ...
    • An Intermittent Live Cell Imaging Screen for siRNA Enhancers and Suppressors of a Kinesin-5 Inhibitor 

      Tsui, Melody; Xie, Tiao; Orth, James Daniel; Carpenter, Anne E.; Rudnicki, Stewart; Kim, Suejong; Shamu, Caroline Elizabeth; Mitchison, Timothy J. (Public Library of Science, 2009)
      Kinesin-5 (also known as Eg5, KSP and Kif11) is required for assembly of a bipolar mitotic spindle. Small molecule inhibitors of Kinesin-5, developed as potential anti-cancer drugs, arrest cell in mitosis and promote ...
    • Mitogen-Activated Protein Kinases Regulate Susceptibility to Ventilator-Induced Lung Injury 

      Dolinay, Tamás; Wu, Wei; Kaminski, Naftali; Ifedigbo, Emeka; Kaynar, A. Murat; Szilasi, Mária; Watkins, Simon C.; Ryter, Stefan W.; Hoetzel, Alexander; Choi, Augustine M.K. (Public Library of Science, 2008)
      Background: Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance ...
    • Oxidative Stress Impairs the Heat Stress Response and Delays Unfolded Protein Recovery 

      Adachi, Masaaki; Liu, Yaohua; Fujii, Kyoko; Calderwood, Stuart K.; Nakai, Akira; Imai, Kohzoh; Shinomura, Yasuhisa (Public Library of Science, 2009)
      Background: Environmental changes, air pollution and ozone depletion are increasing oxidative stress, and global warming threatens health by heat stress. We now face a high risk of simultaneous exposure to heat and oxidative ...
    • Polychlorinated Biphenyls (PCBs) Enhance Metastatic Properties of Breast Cancer Cells by Activating Rho-Associated Kinase (ROCK) 

      Liu, Sijin; Li, Shitao; Du, Yuguo (Public Library of Science, 2010)
      Background: Polychlorinated biphenyls (PCBs) are a family of structurally related chlorinated aromatic hydrocarbons. Numerous studies have documented a wide spectrum of biological effects of PCBs on human health, such as ...
    • Rule-Based Cell Systems Model of Aging using Feedback Loop Motifs Mediated by Stress Responses 

      Kriete, Andres; Bosl, William; Booker, Glenn (Public Library of Science, 2010)
      Investigating the complex systems dynamics of the aging process requires integration of a broad range of cellular processes describing damage and functional decline co-existing with adaptive and protective regulatory ...
    • The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth 

      Firestein, Ron; Blander, Gil; Michan, Shaday; Oberdoerffer, Philipp; Luikenhuis, Sandra; de Cabo, Rafael; Guarente, Leonard P.; Ogino, Shuji; Campbell, Jennifer; Bhimavarapu, Anupama; Fuchs, Charles Stewart; Hahn, William C.; Sinclair, David Andrew (Public Library of Science, 2008)
      Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from manipulating these same ...