Browsing HMS Scholarly Articles by Keyword "cellular microbiology and pathogenesis"

Now showing items 1-14 of 14

    • Bacterial and Host Determinants of MAL Activation upon EPEC Infection: The Roles of Tir, ABRA, and FLRT3 

      Heath, Robert John William; Leong, John M.; Visegrády, Balázs; Machesky, Laura M.; Xavier, Ramnik (Public Library of Science, 2011)
      Infection of host cells by pathogenic microbes triggers signal transduction pathways leading to a multitude of host cell responses including actin cytoskeletal re-arrangements and transcriptional programs. The diarrheagenic ...

    • Comparative Proteomic Analysis of the PhoP Regulon in Salmonella enterica Serovar Typhi Versus Typhimurium 

      Lebrun, Lauren M.; Sheikh, Alaullah; Logvinenko, Tanya; Tarique, Abdullah; Krastins, Bryan; Qadri, Firdausi; Charles, Richelle Candice; Harris, Jason B.; Chase, Michael Richard; Larocque, Regina Celes; Rollins, Sean McKenzie; Hohmann, Elizabeth Louise; Rosenberg, Ian Morley; Sarracino, David A.; Calderwood, Stephen Beaven; Ryan, Edward Thomas (Public Library of Science, 2009)
      Background: S. Typhi, a human-restricted Salmonella enterica serovar, causes a systemic intracellular infection in humans (typhoid fever). In comparison, S. Typhimurium causes gastroenteritis in humans, but causes a systemic ...

    • Complement Receptor 1 Is a Sialic Acid-Independent Erythrocyte Receptor of Plasmodium falciparum 

      Spadafora, Carmenza; Awandare, Gordon A.; Kopydlowski, Karen M.; Czege, Jozsef; Moch, J. Kathleen; Finberg, Robert W.; Tsokos, George C.; Stoute, José A. (Public Library of Science, 2010)
      Plasmodium falciparum is a highly lethal malaria parasite of humans. A major portion of its life cycle is dedicated to invading and multiplying inside erythrocytes. The molecular mechanisms of erythrocyte invasion are ...

    • A Complex Extracellular Sphingomyelinase of Pseudomonas aeruginosa Inhibits Angiogenesis by Selective Cytotoxicity to Endothelial Cells 

      Vasil, Michael L.; Stonehouse, Martin J.; Vasil, Adriana I.; Wadsworth, Sandra J.; Goldfine, Howard; Bolcome, Robert E.; Chan, Joanne (Public Library of Science, 2009)
      The hemolytic phospholipase C (PlcHR) expressed by Pseudomonas aeruginosa is the original member of a Phosphoesterase Superfamily, which includes phosphorylcholine-specific phospholipases C (PC-PLC) produced by frank and ...

    • DNA Damage and Reactive Nitrogen Species are Barriers to Vibrio cholerae Colonization of the Infant Mouse Intestine 

      Davies, Bryan William; Bogard, Ryan; Dupes, Nicole M.; Gerstenfeld, Tyler A. I.; Simmons, Lyle A.; Mekalanos, John J. (Public Library of Science, 2011)
      Ingested Vibrio cholerae pass through the stomach and colonize the small intestines of its host. Here, we show that V. cholerae requires at least two types of DNA repair systems to efficiently compete for colonization of ...

    • In Vitro Priming Recapitulates In Vivo HIV-1 Specific T Cell Responses, Revealing Rapid Loss of Virus Reactive CD4+ T Cells in Acute HIV-1 Infection 

      Lubong Sabado, Rachel; Kavanagh, Daniel Garrett; Kaufmann, Daniel; Fru, Karlhans; Babcock, Ethan; Rosenberg, Eric Scott; Walker, Bruce David; Lifson, Jeffrey; Bhardwaj, Nina; Larsson, Marie (Public Library of Science, 2009)
      Background: The requirements for priming of HIV-specific T cell responses initially seen in infected individuals remain to be defined. Activation of T cell responses in lymph nodes requires cell-cell contact between T cells ...

    • A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor 

      Hett, Erik Christian; Chao, Michael; Deng, Lynn L.; Rubin, Eric Joseph (Public Library of Science, 2008)
      The final stage of bacterial cell division requires the activity of one or more enzymes capable of degrading the layers of peptidoglycan connecting two recently developed daughter cells. Although this is a key step in cell ...

    • The Pathogenic Properties of a Novel and Conserved Gene Product, KerV, in Proteobacteria 

      An, Dingding; Apidianakis, Yiorgos; Boechat, Ana Laura; Baldini, Regina L.; Goumnerov, Boyan C.; Rahme, Laurence G. (Public Library of Science, 2009)
      Identification of novel virulence factors is essential for understanding bacterial pathogenesis and designing antibacterial strategies. In this study, we uncover such a factor, termed KerV, in Proteobacteria. Experiments ...

    • PerR Confers Phagocytic Killing Resistance and Allows Pharyngeal Colonization by Group A Streptococcus 

      Gryllos, Ioannis; Kalish, Leslie A.; Wessels, Michael Robert; Grifantini, Renata; Colaprico, Annalisa; Cary, Max E.; Hakansson, Anders; Carey, David W.; Suarez-Chavez, Maria; Kalish, Leslie A.; Mitchell, Paul D.; White, Gary L.; Wessels, Michael Robert (Public Library of Science, 2008)
      The peroxide response transcriptional regulator, PerR, is thought to contribute to virulence of group A Streptococcus (GAS); however, the specific mechanism through which it enhances adaptation for survival in the human ...

    • Plasma Gelsolin Depletion and Circulating Actin in Sepsis—A Pilot Study 

      Lee, Po-Shun; Patel, Sanjay R; Christiani, David C.; Bajwa, Ednan Khalid; Stossel, Thomas Peter; Waxman, Aaron Bradley (Public Library of Science, 2008)
      Background: Depletion of the circulating actin-binding protein, plasma gelsolin (pGSN) has been described in septic patients and animals. We hypothesized that the extent of pGSN reduction correlates with outcomes of septic ...

    • Prokayrotic Ubiquitin-Like Protein (Pup) Proteome of Mycobacterium tuberculosis 

      Festa, Richard A.; McAllister, Fiona Elizabeth; Pearce, Michael J.; Mintseris, Julian; Burns, Kristin E.; Gygi, Steven P.; Darwin, K. Heran (Public Library of Science, 2010)
      Prokaryotic ubiquitin-like protein (Pup) in Mycobacterium tuberculosis (Mtb) is the first known post-translational small protein modifier in prokaryotes, and targets several proteins for degradation by a bacterial proteasome ...

    • The Salmonella SPI2 Effector SseI Mediates Long-Term Systemic Infection by Modulating Host Cell Migration 

      McLaughlin, Laura M.; Govoni, Gregory R.; Gerke, Christiane; Gopinath, Smita; Peng, Kaitian; Laidlaw, Grace; Chien, Yueh-Hsiu; Li, Zhigang; Monack, Denise; Jeong, Ha-Won; Brown, Matthew D.; Sacks, David Barry (Public Library of Science, 2009)
      Host-adapted strains of Salmonella enterica cause systemic infections and have the ability to persist systemically for long periods of time despite the presence of a robust immune response. Chronically infected hosts are ...

    • Systematic genetic nomenclature for type VII secretion systems 

      Bitter, Wilbert; Houben, Edith N. G.; Bottai, Daria; Brodin, Priscille; Cox, Jeffery S.; Derbyshire, Keith; Gao, Lian-Yong; Gey van Pittius, Nicolaas C.; Pym, Alexander S.; Cole, Stewart T.; Brosch, Roland; Rall, Glenn F.; Brown, Eric J.; Fortune, Sarah Merritt; Liu, Jun; Rubin, Eric Joseph; Sherman, David R. (Public Library of Science, 2009)

    • Type IV Secretion-Dependent Activation of Host MAP Kinases Induces an Increased Proinflammatory Cytokine Response to Legionella pneumophila 

      Shin, Sunny; Case, Christopher L.; Archer, Kristina A.; Nogueira, Catarina V.; Kobayashi, Koichi S; Flavell, Richard A.; Roy, Craig R.; Zamboni, Dario S. (Public Library of Science, 2008)
      The immune system must discriminate between pathogenic and nonpathogenic microbes in order to initiate an appropriate response. Toll-like receptors (TLRs) detect microbial components common to both pathogenic and nonpathogenic ...