Browsing HMS Scholarly Articles by Keyword "central nervous system"

Now showing items 1-7 of 7

    • Diffusion MRI of Structural Brain Plasticity Induced by a Learning and Memory Task 

      Blumenfeld-Katzir, Tamar; Pasternak, Ofer; Dagan, Michael; Assaf, Yaniv (Public Library of Science, 2011)
      Background: Activity-induced structural remodeling of dendritic spines and glial cells was recently proposed as an important factor in neuroplasticity and suggested to accompany the induction of long-term potentiation ...

    • Maternal thyroid hormones are transcriptionally active during embryo–foetal development: results from a novel transgenic mouse model 

      Nucera, Carmelo; Muzzi, Patrizia; Tiveron, Cecilia; Farsetti, Antonella; Regina, Federico La; Foglio, Benedetta; Shih, Shou-Ching; Moretti, Fabiola; Pietra, Linda Della; Mancini, Francesca; Sacchi, Ada; Trimarchi, Francesco; Vercelli, Alessandro; Pontecorvi, Alfredo (Blackwell Publishing Ltd, 2009)
      Abstract Even though several studies highlighted the role of maternal thyroid hormones (THs) during embryo–foetal development, direct evidence of their interaction with embryonic thyroid receptors (TRs) is still lacking. ...

    • Negative Associations between Corpus Callosum Midsagittal Area and IQ in a Representative Sample of Healthy Children and Adolescents 

      Ganjavi, Hooman; Lewis, John D.; Bellec, Pierre; MacDonald, Penny A.; Waber, Deborah Paula; Evans, Alan C.; Karama, Sherif (Public Library of Science, 2011)
      Documented associations between corpus callosum size and cognitive ability have heretofore been inconsistent potentially owing to differences in sample characteristics, differing methodologies in measuring CC size, or the ...

    • Physiological and Pathological Role of Alpha-Synuclein in Parkinson’s Disease through Iron Mediated Oxidative Stress; The Role of a Putative Iron-Responsive Element 

      Olivares, David; Huang, Xudong; Branden, Lars; Greig, Nigel H.; Rogers, Jack Timothy (Molecular Diversity Preservation International (MDPI), 2009)
      Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder after Alzheimer’s disease (AD) and represents a large health burden to society. Genetic and oxidative risk factors have been proposed ...

    • Quality assessment and control of tissue specific RNA-seq libraries of Drosophila transgenic RNAi models 

      Amaral, Andreia J.; Brito, Francisco F.; Chobanyan, Tamar; Yoshikawa, Seiko; Yokokura, Takakazu; Van Vactor, David; Gama-Carvalho, Margarida (Frontiers Media S.A., 2014)
      RNA-sequencing (RNA-seq) is rapidly emerging as the technology of choice for whole-transcriptome studies. However, RNA-seq is not a bias free technique. It requires large amounts of RNA and library preparation can introduce ...

    • Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases 

      Olivares, Ana Maria; Moreno-Ramos, Oscar Andrés; Haider, Neena B. (Libertas Academica, 2015)
      The nuclear hormone receptor (NHR) superfamily is composed of a wide range of receptors involved in a myriad of important biological processes, including development, growth, metabolism, and maintenance. Regulation of such ...

    • Sporadic hemangioblastomas are characterized by cryptic VHL inactivation 

      Shankar, Ganesh Mani; Taylor-Weiner, Amaro; Lelic, Nina; Jones, Robert T; Kim, James C; Francis, Joshua M; Abedalthagafi, Malak S; Borges, Lawrence Francis; Coumans, Jean-Valery C E; Curry, William Thomas; Nahed, Brian Vala; Shin, John H; Paek, Sun Ha; Park, Sung-Hye; Stewart, Chip; Lawrence, Michael S; Cibulskis, Kristian; Thorner, Aaron R; Van Hummelen, Paul; Stemmer-Rachamimov, Anat; Batchelor, Tracy Todd; Carter, Scott Lambert; Hoang, Mai P; Santagata, Sandro; Louis, David N.; Barker, Frederick George; Meyerson, Matthew Langer; Getz, Gad A; Brastianos, Priscilla Kalliope; Cahill, Daniel P. (Springer Nature, 2014)
      Hemangioblastomas consist of 10-20% neoplastic “stromal” cells within a vascular tumor cell mass of reactive pericytes, endothelium and lymphocytes. Familial cases of central nervous system hemangioblastoma uniformly result ...