Browsing HMS Scholarly Articles by Keyword "chemistry"

Now showing items 1-6 of 6

    • Guarding Embryo Development of Zebrafish by Shell Engineering: A Strategy to Shield Life from Ozone Depletion 

      Tang, Yanyan; Pan, Haihua; Xu, Xurong; Tang, Ruikang; Wang, Ben; Liu, Peng (Public Library of Science, 2010)
      Background: The reduced concentration of stratospheric ozone results in an increased flux of biologically damaging mid-ultraviolet radiation (UVB, 280 to 320 nm) reaching earth surfaces. Environmentally relevant levels of ...

    • Identification of Thioredoxin Glutathione Reductase Inhibitors That Kill Cestode and Trematode Parasites 

      Ross, Fabiana; Hernández, Paola; Porcal, Williams; López, Gloria V.; Cerecetto, Hugo; González, Mercedes; Basika, Tatiana; Carmona, Carlos; Fló, Martín; Maggioli, Gabriela; Bonilla, Mariana; Boiani, Mariana; Salinas, Gustavo; Gladyshev, Vadim (Public Library of Science, 2012)
      Parasitic flatworms are responsible for serious infectious diseases that affect humans as well as livestock animals in vast regions of the world. Yet, the drug armamentarium available for treatment of these infections is ...

    • The Location and Nature of General Anesthetic Binding Sites on the Active Conformation of Firefly Luciferase; A Time Resolved Photolabeling Study 

      Shanmugasundararaj, Sivananthaperumal; Lehle, Simon; Yamodo, Herve I.; Husain, S. Shaukat; Tseng, Claire; Nguyen, Khanh; Addona, George H.; Miller, Keith Wyatt (Public Library of Science, 2012)
      Firefly luciferase is one of the few soluble proteins that is acted upon by a wide variety of general anesthetics and alcohols; they inhibit the ATP–driven production of light. We have used time–resolved photolabeling to ...

    • Preservation of Mouse Sperm by Convective Drying and Storing in 3-O-Methyl-D-Glucose 

      Liu, Jie; Lee, Gloria Y.; Lawitts, Joel A.; Toner, Mehmet; Biggers, John Dennis (Public Library of Science, 2012)
      With the fast advancement in the genetics and bio-medical fields, the vast number of valuable transgenic and rare genetic mouse models need to be preserved. Preservation of mouse sperm by convective drying and subsequent ...

    • Small-Molecule Inhibitors of Dengue-Virus Entry 

      Schmidt, Aaron Gregory; Lee, Kyungae; Yang, Priscilla; Harrison, Stephen C. (Public Library of Science, 2012)
      Flavivirus envelope protein (E) mediates membrane fusion and viral entry from endosomes. A low-pH induced, dimer-to-trimer rearrangement and reconfiguration of the membrane-proximal "stem" of the E ectodomain draw together ...

    • Structural Basis of PP2A Inhibition by Small t Antigen 

      Cho, Uhn-Soo; Morrone, Seamus; Sablina, Anna A; Arroyo, Jason D; Hahn, William C.; Xu, Wenqing (Public Library of Science, 2007)
      The SV40 small t antigen (ST) is a potent oncoprotein that perturbs the function of protein phosphatase 2A (PP2A). ST directly interacts with the PP2A scaffolding A subunit and alters PP2A activity by displacing regulatory ...