Browsing HMS Scholarly Articles by Keyword "computer modeling"

Now showing items 1-4 of 4

    • Analysis Method and Experimental Conditions Affect Computed Circadian Phase from Melatonin Data 

      Klerman, Hadassa; St. Hilaire, Melissa A.; Gronfier, Claude; Santhi, Nayantara; Kronauer, Richard E.; Gooley, Joshua James; Hull, Joseph Thomas; Lockley, Steven Ward; Wang, Wei; Klerman, Elizabeth Beryl (Public Library of Science, 2012)
      Accurate determination of circadian phase is necessary for research and clinical purposes because of the influence of the master circadian pacemaker on multiple physiologic functions. Melatonin is presently the most accurate ...

    • Associative memory in chronic schizophrenia: a computational model 

      Han, S Duke; Nestor, Paul Gerard; Shenton, Martha Elizabeth; Niznikiewicz, Margaret A.; Hannah, Gordon; McCarley, Robert William (Elsevier BV, 2003)
      We developed a computer model to simulate associative memory recall of patients with chronic schizophrenia. Model inputs consisted of words derived from normative data that differed in terms of connectivity and network ...

    • Combinatorial Complexity and Compositional Drift in Protein Interaction Networks 

      Deeds, Eric J.; Krivine, Jean; Feret, Jérôme; Danos, Vincent; Fontana, Walter (Public Library of Science, 2012)
      The assembly of molecular machines and transient signaling complexes does not typically occur under circumstances in which the appropriate proteins are isolated from all others present in the cell. Rather, assembly must ...

    • A Novel Small-Molecule Tumor Necrosis Factor \(\alpha\) Inhibitor Attenuates Inflammation in a Hepatitis Mouse Model 

      Ma, Li; Gong, Haiyan; Zhu, Haiyan; Ji, Qing; Su, Pei; Liu, Peng; Cao, Shannan; Yao, Jianfeng; Jiang, Linlin; Han, Mingzhe; Ma, Xiaotong; Xiong, Dongsheng; Luo, Hongbo; Wang, Fei; Zhou, Jiaxi; Xu, Yuanfu (American Society for Biochemistry & Molecular Biology (ASBMB), 2014)
      Over-expression of tumor necrosis factor α (TNFα) is a hallmark of many inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease and septic shock and hepatitis, making it a potential therapeutic ...