Browsing HMS Scholarly Articles by Keyword "copy number alterations"

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    • Ioncopy: a novel method for calling copy number alterations in amplicon sequencing data including significance assessment 

      Budczies, Jan; Pfarr, Nicole; Stenzinger, Albrecht; Treue, Denise; Endris, Volker; Ismaeel, Fakher; Bangemann, Nikola; Blohmer, Jens-Uwe; Dietel, Manfred; Loibl, Sibylle; Klauschen, Frederick; Weichert, Wilko; Denkert, Carsten (Impact Journals LLC, 2016)
      Recently, it has been demonstrated that calling of copy number alterations (CNAs) from amplicon sequencing (AS) data is feasible. Most approaches, however, require non-tumor (germline) DNA for data normalization. Here, we ...

    • IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer 

      Day, Elizabeth; Poulogiannis, George; McCaughan, Frank; Mulholland, Shani; Arends, Mark J; Ibrahim, Ashraf E K; Dear, Paul H (Blackwell Publishing Ltd, 2013)
      Copy number alterations are frequently found in colorectal cancer (CRC), and recurrent gains or losses are likely to correspond to regions harbouring genes that promote or impede carcinogenesis respectively. Gain of ...