Browsing HMS Scholarly Articles by Keyword "cytokines"
Now showing items 1-14 of 14
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Age-Dependent Maturation of Toll-Like Receptor-Mediated Cytokine Responses in Gambian Infants
(Public Library of Science, 2011)The global burden of neonatal and infant mortality due to infection is staggering, particularly in resource-poor settings. Early childhood vaccination is one of the major interventions that can reduce this burden, but there ... -
An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium
(Ovid Technologies (Wolters Kluwer Health), 1993)Accumulation of monocyte-derived foam cells in focal areas of the arterial intima is a key step in early atherogenesis. We investigated the expression of vascular cell adhesion molecule-1 (VCAM-1), a mononuclear leukocyte ... -
Differential Roles of Direct and Indirect Allorecognition Pathways in the Rejection of Skin and Corneal Transplants
(Ovid Technologies (Wolters Kluwer Health), 2009)Background It is generally accepted that all transplants are not rejected in the same fashion. However, the extrinsic and intrinsic factors that control the recognition and rejection of a particular allograft by the ... -
Essential Role of MFG-E8 for Phagocytic Properties of Microglial Cells
(Public Library of Science, 2013)Milk fat globule factor-E8 (MFG-E8) has been regarded as a key factor involved in the phagocytosis of apoptotic cells. We induced a lentivirus into the microglial cells for the augmentation or abrogation of MFG-E8 expression ... -
Genome-Wide Expression Profiling of Five Mouse Models Identifies Similarities and Differences with Human Psoriasis
(Public Library of Science, 2011)Development of a suitable mouse model would facilitate the investigation of pathomechanisms underlying human psoriasis and would also assist in development of therapeutic treatments. However, while many psoriasis mouse ... -
Induction of Endothelial-Leukocyte Interaction by Interferon-\(\gamma\) Requires Coactivation of Nuclear Factor-\(\kappa\)B
(American Heart Association, 2001)To determine whether nuclear factor (NF)-\(\kappa\) B is necessary to confer endothelial cell responsiveness to interferon (INF)-\(\gamma\) in terms of vascular cell adhesion molecule (VCAM)-1 expression and leukocyte ... -
The Inflammatory Response to Double Stranded DNA in Endothelial Cells Is Mediated by by NF\(\kappa\)B and TNF\(\alpha\)
(Public Library of Science, 2011)Endothelial cells represent an important barrier between the intravascular compartment and extravascular tissues, and therefore serve as key sensors, communicators, and amplifiers of danger signals in innate immunity and ... -
The influence of atopy and asthma on immune responses in inner‐city adults
(John Wiley and Sons Inc., 2016)Abstract Asthma in the inner‐city population is usually atopic in nature, and is associated with significant morbidity and mortality. However, the underlying immune abnormalities that underlie asthma in urban adults have ... -
Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6
(American Society for Clinical Investigation, 1990)The cells that make up blood vessel walls appear to participate actively in local immune and inflammatory responses, as well as in certain vascular diseases. We tested here whether smooth muscle cells (SMC) can produce the ... -
An shRNA-Based Screen of Splicing Regulators Identifies SFRS3 as a Negative Regulator of IL-1β Secretion
(Public Library of Science, 2011)The generation of diversity and plasticity of transcriptional programs are key components of effective vertebrate immune responses. The role of Alternative Splicing has been recognized, but it is underappreciated and poorly ... -
Strain Differences Influence Murine Pulmonary Responses to Stachybotrys chartarum
(American Thoracic Society, 2006)When the fungus Stachybotrys chartarum is inhaled, its mycotoxins may cause lung injury and inflammation. The severity of human responses to S. chartarum in both occupational and home settings varies widely. To explore ... -
TGF-β Suppresses β-Catenin-Dependent Tolerogenic Activation Program in Dendritic Cells
(Public Library of Science, 2011)The mechanisms that underlie the critical dendritic cell (DC) function in maintainance of peripheral immune tolerance are incompletely understood, although the β-catenin signaling pathway is critical for this role. The ... -
TNF-α/IL-10 Ratio Correlates with Burn Severity and May Serve as a Risk Predictor of Increased Susceptibility to Infections
(Frontiers Media S.A., 2016)Severe burn injury renders patients susceptible to multiple infection episodes; however, identifying specific patient groups at high risk remains challenging. Burn-induced inflammatory response dramatically modifies the ... -
The Upper Airway Response to Pollen is Enhanced by Exposure to Combustion Particulates: A Pilot Human Experimental Challenge Study.
(National Institute of Environmental Health Sciences, 2003)Although human experimental studies have shown that gaseous pollutants enhance the inflammatory response to allergens, human data on whether combustion particulates enhance the inflammatory response to allergen are limited. ...