Now showing items 1-19 of 19

    • The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts 

      Emilsson, Valur; Hinney, Anke; Heid, Iris M; Zhu, Xiaofeng; Thorleifsson, Gudmar; Gunnarsdottir, Steinunn; Walters, G. Bragi; Thorsteinsdottir, Unnur; Kong, Augustine; Gulcher, Jeffrey; Nguyen, Thuy Trang; Scherag, André; Pfeufer, Arne; Meitinger, Thomas; Brönner, Günter; Rief, Winfried; Soto-Quiros, Manuel E; Avila, Lydiana; Groop, Leif; Tuomi, Tiinamaija; Isomaa, Bo; Bengtsson, Kristina; Butler, Johannah L; Vollmert, Caren; Celedón, Juan C; Wichmann, H. Erich; Hebebrand, Johannes; Stefansson, Kari; Abecasis, Gonçalo; Lyon, Helen N; Su, Jessica Ann Lasky; Klanderman, Barbara Jordan; Raby, Benjamin Alexander; Silverman, Edwin Kepner; Weiss, Scott Tillman; Laird, Nan M.; Ding, Xiao; Cooper, Richard S; Fox, Caroline; O'Donnell, Christopher Joseph; Lange, Christoph; Hirschhorn, Joel Naom (Public Library of Science, 2007)
      A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI and homozygosity for the ...
    • Blockade of VEGFR2 and Not VEGFR1 Can Limit Diet-Induced Fat Tissue Expansion: Role of Local versus Bone Marrow-Derived Endothelial Cells 

      Tam, Joshua; Duda, Dan Gabriel; Perentes, Jean Y.; Quadri, Rehan S.; Fukumura, Dai; Jain, Rakesh K. (Public Library of Science, 2009)
      Background: We investigated if new vessel formation in fat involves the contribution of local tissue-derived endothelial cells (i.e., angiogenesis) or bone marrow-derived cells (BMDCs, i.e. vasculogenesis) and if antiangiogenic ...
    • Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits 

      Segrè, Ayellet V.; Groop, Leif; Mootha, Vamsi Krishna; Daly, Mark Joseph; Altshuler, David Matthew (Public Library of Science, 2010)
      Mitochondrial dysfunction has been observed in skeletal muscle of people with diabetes and insulin-resistant individuals. Furthermore, inherited mutations in mitochondrial DNA can cause a rare form of diabetes. However, ...
    • Evaluation of Association of HNF1B Variants with Diverse Cancers: Collaborative Analysis of Data from 19 Genome-Wide Association Studies 

      Elliott, Katherine S.; Zeggini, Eleftheria; McCarthy, Mark I.; Gudmundsson, Julius; Sulem, Patrick; Stacey, Simon N.; Thorlacius, Steinunn; Amundadottir, Laufey; Grönberg, Henrik; Xu, Jianfeng; Gaborieau, Valerie; Eeles, Rosalind A.; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Muir, Kenneth; Hwang, Shih-Jen; Spitz, Margaret R.; Zanke, Brent; Carvajal-Carmona, Luis; Brown, Kevin M.; Hayward, Nicholas K.; Macgregor, Stuart; Tomlinson, Ian P. M.; Lemire, Mathieu; Amos, Christopher I.; Murabito, Joanne M.; Isaacs, William B.; Easton, Douglas F.; Brennan, Paul; Barkardottir, Rosa B.; Gudbjartsson, Daniel F.; Rafnar, Thorunn; Chanock, Stephen J.; Stefansson, Kari; Australian Melanoma Family Study Investigators; The PanScan Consortium; Hunter, David J.; Ioannidis, John (Public Library of Science, 2010)
      Background: Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk. We aimed to identify whether these variants may ...
    • Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes 

      Marselli, Lorella; Thorne, Jeffrey; Dahiya, Sonika; Sgroi, Dennis Charles; Sharma, Arun J.; Bonner-Weir, Susan; Weir, Gordon Campbell; Marchetti, Piero (Public Library of Science, 2010)
      Background: Changes in gene expression in pancreatic beta-cells from type 2 diabetes (T2D) should provide insights into their abnormal insulin secretion and turnover. Methodology/Principal Findings: Frozen sections were ...
    • Genetic evidence of serum phosphate-independent functions of FGF-23 on bone 

      Sitara, Despina; Kim, Somi; Razzaque, Mohammed Shawkat; Bergwitz, Clemens; Taguchi, Takashi; Schüler, Christiane; Erben, Reinhold G.; Lanske, Beate Klara Maria (Public Library of Science, 2008)
      Maintenance of physiologic phosphate balance is of crucial biological importance, as it is fundamental to cellular function, energy metabolism, and skeletal mineralization. Fibroblast growth factor-23 (FGF-23) is a master ...
    • Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution 

      Lindgren, Cecilia M.; Heid, Iris M.; Randall, Joshua C.; Lamina, Claudia; Steinthorsdottir, Valgerdur; Speliotes, Elizabeth K.; Thorleifsson, Gudmar; Willer, Cristen J.; Herrera, Blanca M.; Jackson, Anne U.; Lim, Noha; Scheet, Paul; Soranzo, Nicole; Amin, Najaf; Aulchenko, Yurii S.; Chambers, John C.; Drong, Alexander; Luan, Jian'an; Rivadeneira, Fernando; Sanna, Serena; Timpson, Nicholas J.; Zillikens, M. Carola; Almgren, Peter; Bandinelli, Stefania; Bennett, Amanda J.; Bergman, Richard N.; Bonnycastle, Lori L.; Bumpstead, Suzannah J.; Chanock, Stephen J.; Cherkas, Lynn; Chines, Peter; Coin, Lachlan; Cooper, Cyrus; Crawford, Gabriel; Doering, Angela; Dominiczak, Anna; Doney, Alex S. F.; Ebrahim, Shah; Elliott, Paul; Erdos, Michael R.; Estrada, Karol; Ferrucci, Luigi; Fischer, Guido; Forouhi, Nita G.; Gieger, Christian; Grallert, Harald; Groves, Christopher J.; Grundy, Scott; Guiducci, Candace; Hadley, David; Hamsten, Anders; Havulinna, Aki S.; Holle, Rolf; Holloway, John W.; Illig, Thomas; Isomaa, Bo; Jacobs, Leonie C.; Jameson, Karen; Jousilahti, Pekka; Karpe, Fredrik; Kuusisto, Johanna; Laitinen, Jaana; Lathrop, G. Mark; Lawlor, Debbie A.; Mangino, Massimo; McArdle, Wendy L.; Meitinger, Thomas; Morken, Mario A.; Morris, Andrew P.; Munroe, Patricia; Narisu, Narisu; Nordström, Anna; Nordström, Peter; Oostra, Ben A.; Palmer, Colin N. A.; Payne, Felicity; Peden, John F.; Prokopenko, Inga; Renström, Frida; Ruokonen, Aimo; Salomaa, Veikko; Sandhu, Manjinder S.; Scuteri, Angelo; Silander, Kaisa; Song, Kijoung; Stringham, Heather M.; Swift, Amy J.; Tuomi, Tiinamaija; Uda, Manuela; Vollenweider, Peter; Waeber, Gerard; Wallace, Chris; Walters, G. Bragi; Weedon, Michael N.; Witteman, Jacqueline C. M.; Zhang, Cuilin; Zhang, Weihua; Caulfield, Mark J.; Collins, Francis S.; Davey Smith, George; Day, Ian N. M.; Franks, Paul W.; Hattersley, Andrew T.; Jarvelin, Marjo-Riitta; Kong, Augustine; Kooner, Jaspal S.; Laakso, Markku; Lakatta, Edward; Mooser, Vincent; Morris, Andrew D.; Peltonen, Leena; Samani, Nilesh J.; Spector, Timothy D.; Strachan, David P.; Tanaka, Toshiko; Tuomilehto, Jaakko; Uitterlinden, André G.; van Duijn, Cornelia M.; Wareham, Nicholas J.; Waterworth, Dawn M.; Boehnke, Michael; Deloukas, Panos; Groop, Leif; Thorsteinsdottir, Unnur; Schlessinger, David; Wichmann, H.-Erich; Frayling, Timothy M.; Abecasis, Gonçalo R.; Loos, Ruth J. F.; Stefansson, Kari; Mohlke, Karen L.; Barroso, Inês; Hirschhorn, Joel Naom; McCarthy, Mark I.; Watkins, Hugh; The Wellcome Trust Case Control Consortium; Hunter, David J.; Hu, Frank B.; Yuan, Xin; Scott, Laura J.; Hofman, Albert; Zhao, Jing Hua; Lyon, Helen N; Qi, Lu (Public Library of Science, 2009)
      To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ...
    • A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels 

      Waterworth, Dawn; O'Rahilly, Stephen; Hivert, Marie-France; Loos, Ruth J. F.; Tanaka, Toshiko; Timpson, Nicholas John; Semple, Robert K.; Soranzo, Nicole; Song, Kijoung; Rocha, Nuno; Grundberg, Elin; Dupuis, Josée; Langenberg, Claudia; Prokopenko, Inga; Sladek, Robert; Aulchenko, Yurii; Waeber, Gerard; Erdmann, Jeanette; Burnett, Mary-Susan; Sattar, Naveed; Devaney, Joseph; Willenborg, Christina; Hingorani, Aroon; Witteman, Jaquelin C. M.; Vollenweider, Peter; Glaser, Beate; Hengstenberg, Christian; Ferrucci, Luigi; Melzer, David; Stark, Klaus; Deanfield, John; Winogradow, Janina; Grassl, Martina; Hall, Alistair S.; Egan, Josephine M.; Ricketts, Sally L.; König, Inke R.; Reinhard, Wibke; Grundy, Scott; Wichmann, H-Erich; Barter, Phil; Mahley, Robert; Kesaniemi, Y. Antero; Rader, Daniel J.; Reilly, Muredach P.; Stewart, Alexandre F. R.; Van Duijn, Cornelia M.; Schunkert, Heribert; Burling, Keith; Deloukas, Panos; Pastinen, Tomi; Samani, Nilesh J.; McPherson, Ruth; Davey Smith, George; Frayling, Timothy M.; Wareham, Nicholas J.; Mooser, Vincent; Spector, Tim D.; Richards, J. Brent; Florez, Jose Carlos; Perry, John R.B.; Saxena, Richa; Evans, David; Meigs, James Benjamin; Thompson, John R.; Epstein, Stephen E. (Public Library of Science, 2009)
      The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for ...
    • Inflammation Determines the Pro-Adhesive Properties of High Extracellular D-Glucose in Human Endothelial Cells In Vitro and Rat Microvessels In Vivo 

      Azcutia, Verónica; Abu-Taha, May; Romacho, Tania; Vázquez-Bella, Marta; Matesanz, Nuria; Luscinskas, Francis William; Rodríguez-Mañas, Leocadio; Sanz, María Jesús; Sánchez-Ferrer, Carlos F.; Peiró, Concepción (Public Library of Science, 2010)
      Background: Hyperglycemia is acknowledged as an independent risk factor for developing diabetes-associated atherosclerosis. At present, most therapeutic approaches are targeted at a tight glycemic control in diabetic ...
    • Insulin Signaling Regulates Mitochondrial Function in Pancreatic β-Cells 

      Liu, Siming; Okada, Terumasa; Assmann, Anke; Soto, Jamie; Liew, Chong-Wee; Bugger, Heiko; Shirihai, Orian S.; Abel, E. Dale; Kulkarni, Rohit Narayan (Public Library of Science, 2009)
      Insulin/IGF-I signaling regulates the metabolism of most mammalian tissues including pancreatic islets. To dissect the mechanisms linking insulin signaling with mitochondrial function, we first identified a mitochondria-tethering ...
    • An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits 

      Zillikens, M. Carola; Farber, Charles R.; Demissie, Serkalem; Soranzo, Nicole; Bianchi, Estelle N.; Grundberg, Elin; Estrada, Karol; Zhou, Yanhua; van Nas, Atila; Moffatt, Miriam F.; Zhai, Guangju; van Meurs, Joyce B.; Pols, Huibert A. P.; Price, Roger I.; Nilsson, Olle; Pastinen, Tomi; Cupples, L. Adrienne; Lusis, Aldons J.; Schadt, Eric E.; Ferrari, Serge; Uitterlinden, André G.; Rivadeneira, Fernando; Spector, Timothy D.; Hsu, Yi Hsiang; Wilson, Scott G.; Liang, Liming; Hofman, Albert; Richards, J. Brent; Karasik, David; Kiel, Douglas P. (Public Library of Science, 2010)
      Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. Genome-wide association studies (GWAS) have become an unbiased approach to identify variations in the genome that potentially affect ...
    • Maternal Plasma 25-Hydroxyvitamin D Concentrations and the Risk for Gestational Diabetes Mellitus 

      Zhang, Cuilin; Qiu, Chunfang; Hu, Frank B.; David, Robert M.; van Dam, Rob M.; Bralley, Alexander; Williams, Michelle A. (Public Library of Science, 2008)
      Background: Evidence is accumulating for a role of vitamin D in maintaining normal glucose homeostasis. However, studies that prospectively examined circulating concentrations of 25-hydroxyvitamin D (25-[OH] D) in relation ...
    • Myeloid Cell-Restricted Insulin Receptor Deficiency Protects Against Obesity-Induced Inflammation and Systemic Insulin Resistance 

      Mauer, Jan; Chaurasia, Bhagirath; Plum, Leona; Quast, Thomas; Hampel, Brigitte; Blüher, Matthias; Kolanus, Waldemar; Kahn, C. Ronald; Brüning, Jens C. (Public Library of Science, 2010)
      A major component of obesity-related insulin resistance is the establishment of a chronic inflammatory state with invasion of white adipose tissue by mononuclear cells. This results in the release of pro-inflammatory ...
    • O-Glycosylation Regulates Ubiquitination and Degradation of the Anti-Inflammatory Protein A20 to Accelerate Atherosclerosis in Diabetic ApoE-Null Mice 

      Shrikhande, Gautam V.; Scali, Salvatore T.; Csizmadia, Eva; Matthey, Michaela; Arjoon, Roy; Patel, Rakesh; Maccariello, Elizabeth R.; Andersen, Nicholas D.; Monahan, Thomas; Studer, Peter; Padilha Guedes, Renata; Usheva, Anny; Da Silva, Cleide Gonsalves; Damrauer, Scott Michael; Putheti, Prabhakar; Siracuse, Jeffrey Joseph; Peterson, Clayton Ross; Essayagh, Sanah; Kocher, Olivier Nicolas; Veves, Aristidis; Kaczmarek, Elzbieta; Ferran, Christiane (Public Library of Science, 2010)
      Background: Accelerated atherosclerosis is the leading cause of morbidity and mortality in diabetic patients. Hyperglycemia is a recognized independent risk factor for heightened atherogenesis in diabetes mellitus (DM). ...
    • Proteomics Reveals Novel Oxidative and Glycolytic Mechanisms in Type 1 Diabetic Patients' Skin Which Are Normalized by Kidney-Pancreas Transplantation 

      Folli, Franco; Guzzi, Valeria; Perego, Lucia; Coletta, Dawn K.; Finzi, Giovanna; Placidi, Claudia; La Rosa, Stefano; Capella, Carlo; Socci, Carlo; Lauro, Davide; Tripathy, Devjit; Jenkinson, Christopher; Paroni, Rita; Orsenigo, Elena; Cighetti, Giuliana; Gregorini, Luisa; Staudacher, Carlo; Secchi, Antonio; Bachi, Angela; Brownlee, Michael; Fiorina, Paolo (Public Library of Science, 2010)
      Background: In type 1 diabetes (T1D) vascular complications such as accelerated atherosclerosis and diffused macro-/microangiopathy are linked to chronic hyperglycemia with a mechanism that is not yet well understood. ...
    • Reproductive Hormone-Dependent and -Independent Contributions to Developmental Changes in Kisspeptin in GnRH-Deficient Hypogonadal Mice 

      Gill, John; Wang, Oulu; Kakar, Shelley; Martinelli, Enzo; Carroll, Rona Stephanie; Kaiser, Ursula Brigitte (Public Library of Science, 2010)
      Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed central regulator of pubertal onset. In mice, there is a neuroanatomical separation of two discrete kisspeptin neuronal populations, ...
    • Rosiglitazone and Myocardial Infarction in Patients Previously Prescribed Metformin 

      Dormuth, Colin R.; Maclure, Malcolm; Carney, Greg; Schneeweiss, Sebastian; Bassett, Ken; Wright, James M. (Public Library of Science, 2009)
      Objective: Rosiglitazone was found associated with approximately a 43% increase in risk of acute myocardial infarction (AMI) in a two meta-analyses of clinical trials. Our objective is to estimate the magnitude of the ...
    • TXNIP Regulates Peripheral Glucose Metabolism in Humans 

      Parikh, Hemang; Carlsson, Emma; Johansson, Lovisa E; Storgaard, Heidi; Poulsen, Pernille; Ladd, Christine; Schulze, P. Christian; Mazzini, Michael J; Jensen, Christine Bjørn; Krook, Anna; Björnholm, Marie; Tornqvist, Hans; Zierath, Juleen R; Ridderstråle, Martin; Vaag, Allan; Groop, Leif C; Chutkow, William Alexander; Saxena, Richa; Altshuler, David Matthew; Lee, Richard Theodore; Mootha, Vamsi Krishna (Public Library of Science, 2007)
      Background: Type 2 diabetes mellitus (T2DM) is characterized by defects in insulin secretion and action. Impaired glucose uptake in skeletal muscle is believed to be one of the earliest features in the natural history of ...
    • Whole Grain, Bran, and Germ Intake and Risk of Type 2 Diabetes: A Prospective Cohort Study and Systematic Review 

      de Munter, Jeroen S. L; Groop, Leif C; Hu, Frank B.; Spiegelman, Donna Lynn; Franz, Mary; van Dam, Rob M. (Public Library of Science, 2007)
      Background: Control of body weight by balancing energy intake and energy expenditure is of major importance for the prevention of type 2 diabetes, but the role of specific dietary factors in the etiology of type 2 diabetes ...