Browsing HMS Scholarly Articles by Keyword "drugs and adverse drug reactions"

Now showing items 1-3 of 3

    • Antiviral Resistance and the Control of Pandemic Influenza 

      Lipsitch, Marc; Cohen, Ted; Murray, Megan Blanche; Levin, Bruce R (Public Library of Science, 2007)
      Background: The response to the next influenza pandemic will likely include extensive use of antiviral drugs (mainly oseltamivir), combined with other transmission-reducing measures. Animal and in vitro studies suggest ...

    • BIM Mediates EGFR Tyrosine Kinase Inhibitor-Induced Apoptosis in Lung Cancers with Oncogenic EGFR Mutations 

      Costa, Daniel Botelho; Halmos, Balázs; Kumar, Amit; Schumer, Susan T; Huberman, Mark Stephen; Boggon, Titus J; Tenen, Daniel Geoffrey; Kobayashi, Susumu (Public Library of Science, 2007)
      Background: Epidermal growth factor receptor (EGFR) mutations are present in the majority of patients with non-small cell lung cancer (NSCLC) responsive to the EGFR tyrosine kinase inhibitors (TKIs) gefitinib or erlotinib. ...

    • Signature-Based Small Molecule Screening Identifies Cytosine Arabinoside as an EWS/FLI Modulator in Ewing Sarcoma 

      Stegmaier, Kimberly; Wong, Jenny S; Ross, Kenneth N; Chow, Kwan T; Peck, David; Wright, Renee D; Lessnick, Stephen L; Kung, Andrew Li-Jen; Golub, Todd R. (Public Library of Science, 2007)
      Background: The presence of tumor-specific mutations in the cancer genome represents a potential opportunity for pharmacologic intervention to therapeutic benefit. Unfortunately, many classes of oncoproteins (e.g., ...