Browsing HMS Scholarly Articles by Keyword "dynamics"

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    • The Stochastic Behavior of a Molecular Switching Circuit with Feedback 

      Krishnamurthy, Supriya; Smith, Eric; Krakauer, David; Fontana, Walter (BioMed Central, 2007)
      Background: Using a statistical physics approach, we study the stochastic switching behavior of a model circuit of multisite phosphorylation and dephosphorylation with feedback. The circuit consists of a kinase and phosphatase ...

    • Thalamic reticular nucleus induces fast and local modulation of arousal state 

      Lewis, Laura D; Voigts, Jakob; Flores, Francisco J; Schmitt, L Ian; Wilson, Matthew A; Halassa, Michael M; Brown, Emery N (eLife Sciences Publications, Ltd, 2015)
      During low arousal states such as drowsiness and sleep, cortical neurons exhibit rhythmic slow wave activity associated with periods of neuronal silence. Slow waves are locally regulated, and local slow wave dynamics are ...