Now showing items 1-5 of 5

    • DIAPH3 Governs the Cellular Transition to the Amoeboid Tumour Phenotype 

      Hager, Martin H; Morley, Samantha; Bielenberg, Diane R; Gao, Sizhen; Morello, Matteo; Holcomb, Ilona N; Liu, Wennuan; Mouneimne, Ghassan; Demichelis, Francesca; Kim, Jayoung; Solomon, Keith R; Adam, Rosalyn M; Isaacs, William B; Higgs, Henry N; Vessella, Robert L; Di Vizio, Dolores; Freeman, Michael R (WILEY-VCH Verlag, 2012)
      Therapies for most malignancies are generally ineffective once metastasis occurs. While tumour cells migrate through tissues using diverse strategies, the signalling networks controlling such behaviours in human tumours ...
    • ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis 

      Konopacki, Filip A.; Wong, Hovy Ho-Wai; Dwivedy, Asha; Bellon, Anaïs; Blower, Michael D.; Holt, Christine E. (The Royal Society, 2016)
      Endocytosis and local protein synthesis (LPS) act coordinately to mediate the chemotropic responses of axons, but the link between these two processes is poorly understood. The endosomal sorting complex required for transport ...
    • Membrane fission by dynamin: what we know and what we need to know 

      Antonny, Bruno; Burd, Christopher; De Camilli, Pietro; Chen, Elizabeth; Daumke, Oliver; Faelber, Katja; Ford, Marijn; Frolov, Vadim A; Frost, Adam; Hinshaw, Jenny E; Kirchhausen, Tom; Kozlov, Michael M; Lenz, Martin; Low, Harry H; McMahon, Harvey; Merrifield, Christien; Pollard, Thomas D; Robinson, Phillip J; Roux, Aurélien; Schmid, Sandra (John Wiley and Sons Inc., 2016)
      Abstract The large GTPase dynamin is the first protein shown to catalyze membrane fission. Dynamin and its related proteins are essential to many cell functions, from endocytosis to organelle division and fusion, and it ...
    • The mother of all endocytosis 

      Clapham, David E (eLife Sciences Publications, Ltd, 2013)
      Massive endocytosis is initiated by a series of steps that involve a sudden influx of calcium ions, changes in mitochondria, and modification of surface proteins by lipids. A better understanding of this process could lead ...
    • Niemann-Pick C1 Affects the Gene Delivery Efficacy of Degradable Polymeric Nanoparticles 

      Eltoukhy, Ahmed A.; Sahay, Gaurav; Cunningham, James M.; Anderson, Daniel G. (American Chemical Society, 2014)
      Despite intensive research effort, the rational design of improved nanoparticulate drug carriers remains challenging, in part due to a limited understanding of the determinants of nanoparticle entry and transport in target ...