Browsing HMS Scholarly Articles by Keyword "lactate"
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A Longitudinal Pilot Proton MRS Investigation of the Manic and Euthymic States of Bipolar Disorder
(Nature Publishing Group, 2012)Several lines of evidence implicate dysfunction in brain energy production as a key component of bipolar disorder. In particular, elevated brain lactate levels observed in this condition suggest a shift from aerobic to ... -
Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology
(Landes Bioscience, 2013)Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of ...