Browsing HMS Scholarly Articles by Keyword "obesity"

Now showing items 1-20 of 67

    • Accumulation of Metabolic Cardiovascular Risk Factors in Black and White Young Adults Over 20 Years 

      Paynter, Nina P.; Kiefe, Catarina I.; Lewis, Cora E.; Loria, Catherine M.; Goff, David C.; Lloyd‐Jones, Donald M. (Blackwell Publishing Ltd, 2015)
      Background: Cross‐sectional clustering of metabolic risk factors for cardiovascular disease in middle‐aged adults is well described, but less is known regarding the order in which risk factors develop through young adulthood ...

    • Adiponectin Deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling 

      Medoff, Benjamin D.; Okamoto, Yoshihisa; Leyton, Patricio; Weng, Meiqian; Sandall, Barry P.; Raher, Michael J.; Kihara, Shinji; Bloch, Kenneth Daniel; Libby, Peter; Luster, Andrew David (American Thoracic Society, 2009)
      Obesity is associated with an increased incidence and severity of asthma, as well as other lung disorders, such as pulmonary hypertension. Adiponectin (APN), an antiinflammatory adipocytokine, circulates at lower levels ...

    • Adipose Tissue Depots and Their Cross‐Sectional Associations With Circulating Biomarkers of Metabolic Regulation 

      Lee, Jane J.; Britton, Kathryn A.; Pedley, Alison; Massaro, Joseph M.; Speliotes, Elizabeth K.; Murabito, Joanne M.; Hoffmann, Udo; Ingram, Cheryl; Keaney, John F.; Vasan, Ramachandran S.; Fox, Caroline S. (John Wiley and Sons Inc., 2016)
      Background: Visceral adipose tissue (VAT) and fatty liver differ in their associations with cardiovascular risk compared with subcutaneous adipose tissue (SAT). Several biomarkers have been linked to metabolic derangements ...

    • Application of combined omics platforms to accelerate biomedical discovery in diabesity 

      Kurland, Irwin J; Accili, Domenico; Burant, Charles; Fischer, Steven M; Kahn, Barbara B; Newgard, Christopher B; Ramagiri, Suma; Ronnett, Gabriele V; Ryals, John A; Sanders, Mark; Shambaugh, Joe; Shockcor, John; Gross, Steven S (Blackwell Publishing Ltd, 2013)
      Diabesity has become a popular term to describe the specific form of diabetes that develops late in life and is associated with obesity. While there is a correlation between diabetes and obesity, the association is not ...

    • Association Between Prolactin and Incidence of Cardiovascular Risk Factors in the Framingham Heart Study 

      Therkelsen, Kate E.; Abraham, Tobin M.; Pedley, Alison; Massaro, Joseph M.; Sutherland, Patrice; Hoffmann, Udo; Fox, Caroline S. (John Wiley and Sons Inc., 2016)
      Background: Prolactin is an anterior pituitary hormone that may modulate the adverse effects of obesity. Prolactin has been associated with cardiovascular disease mortality, but less is known about whether prolactin predicts ...

    • The Association between Sleep Patterns and Obesity in Older Adults 

      Patel, Sanjay R.; Hayes, Amanda L.; Blackwell, Terri; Evans, Daniel S.; Ancoli-Israel, Sonia; Wing, Yun K.; Stone, Katie L. (2014)
      Background: Reduced sleep duration has been increasingly reported to predict obesity. However, timing and regularity of sleep may also be important. In this study, the cross-sectional association between objectively measured ...

    • Association of body mass index and waist circumference with successful ageing: 16 year follow-up of the Whitehall II study 

      Singh-Manoux, Archana; Sabia, Séverine; Bouillon, Kim; Brunner, Eric J; Grodstein, Francine; Elbaz, Alexis; Kivimaki, Mika (2013)
      Objective: We examined whether midlife body mass index (BMI) and waist circumference (WC) predict successful ageing. Design and Methods BMI/WC were assessed in 4869 persons (mean age 51.2, range 42–63 in 1991/93) and ...

    • Association of Fat Density With Subclinical Atherosclerosis 

      Alvey, Nicholas J.; Pedley, Alison; Rosenquist, Klara J.; Massaro, Joseph M.; O'Donnell, Christopher J.; Hoffmann, Udo; Fox, Caroline S. (Blackwell Publishing Ltd, 2014)
      Background: Ectopic fat density is associated with cardiovascular disease (CVD) risk factors above and beyond fat volume. Volumetric measures of ectopic fat have been associated with CVD risk factors and subclinical ...

    • Association of Genetic Variation in \(FTO\) with Risk of Obesity and Type 2 Diabetes with Data from 96,551 East and South Asians 

      Kilpeläinen, T. O.; Sekine, A.; Yajnik, C. S.; Takeuchi, F.; Yamamoto, K.; Mani, K. R.; Been, L. F.; Imamura, M.; Nakashima, E.; Fujisawa, T.; Karasawa, S.; Joglekar, C. V.; Fall, C. H. D.; Sham, P. C.; Shu, X.; Deng, H.; Ikegami, H.; Krishnaveni, G. V.; Sanghera, D. K.; Chuang, L.; Daimon, M.; Hotta, K.; Kooner, J. S.; Chandak, G. R.; Maeda, S.; Dorajoo, R.; Yokota, M.; Takayanagi, R.; Loos, R. J. F.; Song, Yiqing; Li, H.; Liu, C.; Zhu, J.; Liu, Y.; Hu, C.; Yang, Z.; Zhang, W.; Bao, W.; Cha, S.; Wu, Y.; Yang, T.; Choi, B. Y.; Zhou, D.; Chan, J. C.; Lee, N.; Wen, W.; Lu, W.; Chang, Y.; Xiang, Y.; Gao, Y.; Liu, S.; Song, Yiqing; Kwak, S. H.; Shin, H. D.; Park, K. S.; Kim, J. Y.; Lam, K. S. L.; Zheng, W.; Liu, L.; Hu, R.; Kim, Y.; Jia, W.; Chambers, J. C.; Ma, R. C.; Kato, N.; Lin, X. (Springer-Verlag, 2012)
      Aims/hypothesis: \(FTO\) harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for \(FTO\) in obesity risk in Asians, its association with type 2 diabetes, ...

    • Birth Outcomes in a Prospective Pregnancy-Birth Cohort Study of Environmental Risk Factors in Kuwait: The TRACER Study 

      Alseaidan, Mohammad M.S.; Al Wotayan, Rihab; Christophi, Costas A.; Al-Makhseed, Massouma; Abu Awad, Yara; Nassan, Feiby; Ahmed, Ayah; Abraham, Smitha; Boley, Robert Bruce; James-Todd, Tamarra; Wright, Rosalind; Dockery, Douglas William; Behbehani, Kazem (Wiley-Blackwell, 2016)
      Background—Rapid development and westernisation in Kuwait and other Gulf states have been accompanied by rising rates of obesity, diabetes, asthma, and other chronic conditions. Prenatal experiences and exposures may be ...

    • Blockade of VEGFR2 and Not VEGFR1 Can Limit Diet-Induced Fat Tissue Expansion: Role of Local versus Bone Marrow-Derived Endothelial Cells 

      Tam, Joshua; Duda, Dan Gabriel; Perentes, Jean Y.; Quadri, Rehan S.; Fukumura, Dai; Jain, Rakesh K. (Public Library of Science, 2009)
      Background: We investigated if new vessel formation in fat involves the contribution of local tissue-derived endothelial cells (i.e., angiogenesis) or bone marrow-derived cells (BMDCs, i.e. vasculogenesis) and if antiangiogenic ...

    • A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research 

      Yeatts, Karin; Sly, Peter; Martinez, Fernando; Geller, Andrew; Bromberg, Philip; Enright, Paul; Koren, Hillel; Weissman, David; Selgrade, MaryJane; Shore, Stephanie; Weiss, Scott Tillman (National Institute of Environmental Health Sciences, 2006)
      Relative to research on effects of environmental exposures on exacerbation of existing asthma, little research on incident asthma and environmental exposures has been conducted. However, this research is needed to better ...

    • Brown Adipose Tissue Blood Flow and Mass in Obesity: A Contrast Ultrasound Study in Mice 

      Clerte, Maëva; Baron, David William; Brouckaert, Peter; Ernande, Laura; Raher, Michael J.; Flynn, Aidan W.; Picard, Michael Howard; Bloch, Kenneth; Buys, Emmanuel; Scherrer-Crosbie, Marielle (Elsevier BV, 2013)
      Background: When activated by the sympathetic nervous system, brown adipose tissue (BAT) increases energy expenditure to produce heat. Augmenting BAT mass or increasing BAT activation could potentially be used to decrease ...

    • Chronic Insufficient Sleep and Diet Quality: Contributors to Childhood Obesity 

      Cespedes, Elizabeth M.; Hu, Frank B.; Redline, Susan; Rosner, Bernard; Gillman, Matthew W.; Rifas-Shiman, Sheryl L.; Taveras, Elsie M. (2015)
      Objective: To examine associations of chronic insufficient sleep with diet, and whether diet explains the sleep-adiposity relationship. Methods: In Project Viva, 1,046 parents reported children’s sleep duration at 6m and ...

    • Comparing Outcomes of Two Types of Bariatric Surgery in an Adolescent Obese Population: Roux-en-Y Gastric Bypass vs. Sleeve Gastrectomy 

      Maffazioli, Giovana D.; Stanford, Fatima Cody; Campoverde Reyes, Karen J.; Stanley, Takara L.; Singhal, Vibha; Corey, Kathleen E.; Pratt, Janey S.; Bredella, Miriam A.; Misra, Madhusmita (Frontiers Media S.A., 2016)
      Background: Obesity is prevalent among adolescents and is associated with serious health consequences. Roux-en-Y Gastric Bypass (RYGB) and Sleeve Gastrectomy (SG) are bariatric procedures that cause significant weight loss ...

    • Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction 

      Stoeckel, Luke E.; Arvanitakis, Zoe; Gandy, Sam; Small, Dana; Kahn, C. Ronald; Pascual-Leone, Alvaro; Pawlyk, Aaron; Sherwin, Robert; Smith, Philip (F1000Research, 2016)
      Scientific evidence has established several links between metabolic and neurocognitive dysfunction, and epidemiologic evidence has revealed an increased risk of Alzheimer’s disease and vascular dementia in patients with ...

    • A cross-sectional study of osteocalcin and body fat measures among obese adolescents 

      Lenders, Carine M.; Lee, Phillip DK.; Feldman, Henry A.; Wilson, Darrell M.; Abrams, Stephanie H.; Gitelman, Stephen E.; Klish, William J; Wertz, Marcia S.; Taylor, George A.; Alongi, Richard T.; Chen, Tai C.; Holick, Michael F. (2016)
      Osteocalcin (OCN), a marker of osteoblast activity, has been implicated in the regulation of energy metabolism by the skeleton and thus may affect body fat measures. We examined the relationships of OCN to body fat measures ...

    • CXCR3 Controls T-Cell Accumulation in Fat Inflammation 

      Rocha, V. Z.; Folco, Eduardo; Ozdemir, Cafer; Sheikine, Y.; Christen, T.; Sukhova, Galina K.; Tang, E. H. C.; Bittencourt, M. S.; Santos, R. D.; Luster, Andrew David; Cohen, David E; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 2014)
      Objective—Obesity associates with increased numbers of inflammatory cells in adipose tissue (AT), including T cells, but the mechanism of T-cell recruitment remains unknown. This study tested the hypothesis that the chemokine ...

    • Deficiency of FcεR1 increases body weight gain but improves glucose tolerance in diet-induced obese mice 

      Lee, Yun-Jung; Liu, Conglin; Liao, Mengyang; Sukhova, Galina K.; Shirakawa, Jun; Abdennour, Meriem; Iamarene, Karine; Andre, Sebastien; Inouye, Karen; Clement, Karine; Kulkarni, Rohit Narayan; Banks, Alexander; Libby, Peter; Shi, Guo-Ping (Endocrine Society, 2015)
      Prior studies demonstrated increased plasma immunoglobulin E (IgE) in diabetic patients, but the direct participation of IgE in diabetes or obesity remains unknown. This study found that plasma IgE levels correlated inversely ...

    • Different Roles of Mast Cells in Obesity and Diabetes: Lessons from Experimental Animals and Humans 

      Shi, Michael A.; Shi, Guo-Ping (Frontiers Research Foundation, 2012)
      Mast cells (MCs) play an important role in allergic hyperresponsiveness and in defending microorganism infections. Recent studies of experimental animals and humans have suggested that MCs participate in obesity and diabetes. ...