Browsing HMS Scholarly Articles by Keyword "vaccines"
Now showing items 1-6 of 6
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Anti-V3 Monoclonal Antibodies Display Broad Neutralizing Activities against Multiple HIV-1 Subtypes
(Public Library of Science, 2010)Background: The V3 loop of the HIV-1 envelope (Env) glycoprotein gp120 was identified as the “principal neutralizing domain” of HIV-1, but has been considered too variable to serve as a neutralizing antibody (Ab) target. ... -
Characteristics of the Earliest Cross-Neutralizing Antibody Response to HIV-1
(Public Library of Science, 2011)Recent cross-sectional analyses of HIV-1+ plasmas have indicated that broadly cross-reactive neutralizing antibody responses are developed by 10%–30% of HIV-1+ subjects. The timing of the initial development of such ... -
Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides
(Frontiers Media S.A., 2014)Vaccine-elicited cytotoxic T lymphocytes (CTL) recognizing conserved fragments of a pathogen’s proteome could greatly impact infectious diseases and cancers. Enabling this potential are recent advances in mass spectrometry ... -
A global approach to HIV-1 vaccine development
(John Wiley & Sons Ltd., 2013)Summary A global human immunodeficiency virus-1 (HIV-1) vaccine will have to elicit immune responses capable of providing protection against a tremendous diversity of HIV-1 variants. In this review, we first describe the ... -
Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag
(Public Library of Science, 2008)HIV avoids elimination by cytotoxic T-lymphocytes (CTLs) through the evolution of escape mutations. Although there is mounting evidence that these escape pathways are broadly consistent among individuals with similar human ... -
Recognition of HIV-1 Peptides by Host CTL Is Related to HIV-1 Similarity to Human Proteins
(Public Library of Science, 2007)Background: While human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocytes preferentially target specific regions of the viral proteome, HIV-1 features that contribute to immune recognition are not well ...