Now showing items 1-6 of 6

    • Anti-V3 Monoclonal Antibodies Display Broad Neutralizing Activities against Multiple HIV-1 Subtypes 

      Hioe, Catarina E.; Wrin, Terri; Seaman, Michael S.; Yu, Xuesong; Wood, Blake; Self, Steve; Williams, Constance; Gorny, Miroslaw K.; Zolla-Pazner, Susan (Public Library of Science, 2010)
      Background: The V3 loop of the HIV-1 envelope (Env) glycoprotein gp120 was identified as the “principal neutralizing domain” of HIV-1, but has been considered too variable to serve as a neutralizing antibody (Ab) target. ...
    • Characteristics of the Earliest Cross-Neutralizing Antibody Response to HIV-1 

      Mikell, Iliyana; Sather, D. Noah; Kalams, Spyros A.; Altfeld, Marcus; Alter, Galit; Stamatatos, Leonidas (Public Library of Science, 2011)
      Recent cross-sectional analyses of HIV-1+ plasmas have indicated that broadly cross-reactive neutralizing antibody responses are developed by 10%–30% of HIV-1+ subjects. The timing of the initial development of such ...
    • Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides 

      Reinherz, Ellis L.; Keskin, Derin B.; Reinhold, Bruce (Frontiers Media S.A., 2014)
      Vaccine-elicited cytotoxic T lymphocytes (CTL) recognizing conserved fragments of a pathogen’s proteome could greatly impact infectious diseases and cancers. Enabling this potential are recent advances in mass spectrometry ...
    • A global approach to HIV-1 vaccine development 

      Stephenson, Kathryn E; Barouch, Dan H (John Wiley & Sons Ltd., 2013)
      Summary A global human immunodeficiency virus-1 (HIV-1) vaccine will have to elicit immune responses capable of providing protection against a tremendous diversity of HIV-1 variants. In this review, we first describe the ...
    • Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag 

      Brumme, Zabrina L.; Rousseau, Christine M.; Brumme, Chanson J.; Matthews, Philippa; Kadie, Carl; Mullins, James I.; Harrigan, P. Richard; Heckerman, David; Carlson, Jonathan M.; Walker, Bruce David; Goulder, Philip J. (Public Library of Science, 2008)
      HIV avoids elimination by cytotoxic T-lymphocytes (CTLs) through the evolution of escape mutations. Although there is mounting evidence that these escape pathways are broadly consistent among individuals with similar human ...
    • Recognition of HIV-1 Peptides by Host CTL Is Related to HIV-1 Similarity to Human Proteins 

      Rolland, Morgane; Nickle, David C.; Deng, Wenjie; Frahm, Nicole; Learn, Gerald H.; Heckerman, David; Jojic, Nebosja; Jojic, Vladimir; Mullins, James I.; Brander, Christian; Walker, Bruce David (Public Library of Science, 2007)
      Background: While human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocytes preferentially target specific regions of the viral proteome, HIV-1 features that contribute to immune recognition are not well ...