Browsing SPH Scholarly Articles by Title
Now showing items 1124-1143 of 6362
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Clinical Pertinence Metric Enables Hypothesis-Independent Genome-Phenome Analysis for Neurologic Diagnosis
(SAGE Publications, 2014)We describe an “integrated genome-phenome analysis” that combines both genomic sequence data and clinical information for genomic diagnosis. It is novel in that it uses robust diagnostic decision support and combines the ... -
Clinical Preventability of 30‐Day Readmission After Percutaneous Coronary Intervention
(Blackwell Publishing Ltd, 2014)Background: Early readmission after PCI is an important contributor to healthcare expenditures and a target for performance measurement. The extent to which 30‐day readmissions after PCI are preventable is unknown yet ... -
Clinical Research Quo Vadis? Trends in Reporting of Clinical Trials and Observational Study Designs Over Two Decades
(Elmer Press, 2015)Background: Multiple classifications have been developed that classify the medical literature into different levels of evidence to facilitate the evaluation of study results and practice of evidence-based medicine. The ... -
Clinician-identified problems and solutions for delayed diagnosis in primary care: a PRIORITIZE study
(BioMed Central, 2016)Background: Delayed diagnosis in primary care is a common, harmful and costly patient safety incident. Its measurement and monitoring are underdeveloped and underutilised. We created and implemented a novel approach to ... -
Clinicians’ Contributions to the Development of Coronary Artery Stents: A Qualitative Study of Transformative Device Innovation
(Public Library of Science, 2014)Background: Medical device innovation remains poorly understood, and policymakers disagree over how to incentivize early development. We sought to elucidate the components of transformative health care innovation by ... -
Clinicians’ knowledge and practices regarding family planning and intrauterine devices in China, Kazakhstan, Laos and Mexico
(BioMed Central, 2016)Background: It is widely agreed that the practices of clinicians should be based on the best available research evidence, but too often this evidence is not reliably disseminated to people who can make use of it. This ... -
Clonal Evolution in Breast Cancer Revealed by Single Nucleus Genome Sequencing
(2014)SUMMARY Sequencing studies of breast tumor cohorts have identified many prevalent mutations, but provide limited insight into the genomic diversity within tumors. Here, we developed a whole-genome and exome single cell ... -
Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults
(Nature Publishing Group, 2016)Clonal haematopoiesis is thought to be a rare condition that increases in frequency with age and predisposes individuals to haematological malignancy. Recent studies, utilizing next-generation sequencing (NGS), observed ... -
A closer look into DNase I hypersensitivity
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Closing the delivery gaps in pediatric HIV care in Togo, West Africa: using the care delivery value chain framework to direct quality improvement
(Taylor & Francis, 2016)ABSTRACT Providing quality care for all children living with HIV/AIDS remains a global challenge and requires the development of new healthcare delivery strategies. The care delivery value chain (CDVC) is a framework that ... -
Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada
(Public Library of Science, 2013)Background: Combination antiretroviral therapy (ART) has significantly increased survival among HIV-positive adults in the United States (U.S.) and Canada, but gains in life expectancy for this region have not been well ... -
Cloud BioLinux: pre-configured and on-demand bioinformatics computing for the genomics community
(BioMed Central, 2012)Background: A steep drop in the cost of next-generation sequencing during recent years has made the technology affordable to the majority of researchers, but downstream bioinformatic analysis still poses a resource bottleneck ... -
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles
(2014)Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug reaction occurring in up to 1% of ... -
Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation
(BioMed Central, 2010)Background: Numerous studies have demonstrated associations between genetic markers and COPD, but results have been inconsistent. One reason may be heterogeneity in disease definition. Unsupervised learning approaches may ... -
Clustered risk: An ecological understanding of sexual activity among adolescent boys and girls in two urban slums in Monrovia, Liberia
(Elsevier BV, 2019-03)Many young people experience sexual debut before they are able to manage risk in order to avoid adverse consequences. Gender norms, social position, and power can undermine an adolescent's ability to exercise agency in ... -
Clustering of cardiovascular disease risk factors among obese schoolchildren : the Taipei Children Heart Study
(Oxford University Press, 1998)Background: Childhood obesity increases the risk of obesity in adulthood and is associated with cardiovascular disease (CVD) risk factors such as hypertension, diabetes mellitus, and dyslipidemia. Objective: We evaluated ... -
CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids
(John Wiley and Sons Inc., 2015)Abstract Inhaled corticosteroids (ICS) are the most effective controller medications for asthma, and variability in ICS response is associated with genetic variation. Despite ICS treatment, some patients with poor asthma ... -
Co-Operative Additive Effects between HLA Alleles in Control of HIV-1
(Public Library of Science, 2012)Background: HLA class I genotype is a major determinant of the outcome of HIV infection, and the impact of certain alleles on HIV disease outcome is well studied. Recent studies have demonstrated that certain HLA class I ... -
Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins
(Elsevier, 2016)Human immunodeficiency virus type 1 (HIV-1) has evolved a sophisticated strategy to conceal conserved epitopes of its envelope glycoproteins (Env) recognized by antibody-dependent cellular cytotoxicity (ADCC)-mediating ... -
Codynamics of Four Variables Involved in Dengue Transmission and Its Control by Community Intervention: A System of Four Difference Equations
(Hindawi Publishing Corporation, 2014)In the case of Dengue transmission and control, the interaction of nature and society is captured by a system of difference equations. For the purpose of studying the dynamics of these interactions, four variables involved ...