Browsing SPH Scholarly Articles by Title

Now showing items 1131-1150 of 6362

    • Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults 

      Young, Andrew L.; Challen, Grant A.; Birmann, Brenda M.; Druley, Todd E. (Nature Publishing Group, 2016)
      Clonal haematopoiesis is thought to be a rare condition that increases in frequency with age and predisposes individuals to haematological malignancy. Recent studies, utilizing next-generation sequencing (NGS), observed ...

    • A closer look into DNase I hypersensitivity 

      He, Housheng H; Meyer, Clifford; Long, Henry W; Liu, Xiaole Shirley; Brown, Myles Avery (BioMed Central, 2013)

    • Closing the delivery gaps in pediatric HIV care in Togo, West Africa: using the care delivery value chain framework to direct quality improvement 

      Fiori, Kevin; Schechter, Jennifer; Dey, Monica; Braganza, Sandra; Rhatigan, Joseph; Houndenou, Spero; Gbeleou, Christophe; Palerbo, Emmanuel; Tchangani, Elfamozo; Lopez, Andrew; Bensen, Emily; Hirschhorn, Lisa R. (Taylor & Francis, 2016)
      ABSTRACT Providing quality care for all children living with HIV/AIDS remains a global challenge and requires the development of new healthcare delivery strategies. The care delivery value chain (CDVC) is a framework that ...

    • Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada 

      Samji, Hasina; Cescon, Angela; Hogg, Robert S.; Modur, Sharada P.; Althoff, Keri N.; Buchacz, Kate; Burchell, Ann N.; Cohen, Mardge; Gebo, Kelly A.; Gill, M. John; Justice, Amy; Kirk, Gregory; Klein, Marina B.; Korthuis, P. Todd; Martin, Jeff; Napravnik, Sonia; Rourke, Sean B.; Sterling, Timothy R.; Silverberg, Michael J.; Deeks, Stephen; Jacobson, Lisa P.; Bosch, Ronald J.; Kitahata, Mari M.; Goedert, James J.; Moore, Richard; Gange, Stephen J. (Public Library of Science, 2013)
      Background: Combination antiretroviral therapy (ART) has significantly increased survival among HIV-positive adults in the United States (U.S.) and Canada, but gains in life expectancy for this region have not been well ...

    • Cloud BioLinux: pre-configured and on-demand bioinformatics computing for the genomics community 

      Krampis, Konstantinos; Booth, Tim; Chapman, Brad Alan; Tiwari, Bela; Bicak, Mesude; Field, Dawn; Nelson, Karen E (BioMed Central, 2012)
      Background: A steep drop in the cost of next-generation sequencing during recent years has made the technology affordable to the majority of researchers, but downstream bioinformatic analysis still poses a resource bottleneck ...

    • Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles 

      Goldstein, Jacqueline I; Jarskog, L Fredrik; Hilliard, Chris; Alfirevic, Ana; Duncan, Laramie; Fourches, Denis; Huang, Hailiang; Lek, Monkol; Neale, Benjamin M; Ripke, Stephan; Shianna, Kevin; Szatkiewicz, Jin P; Tropsha, Alexander; van den Oord, Edwin JCG; Cascorbi, Ingolf; Dettling, Michael; Gazit, Ephraim; Goff, Donald C; Holden, Arthur L; Kelly, Deanna L; Malhotra, Anil K; Nielsen, Jimmi; Pirmohamed, Munir; Rujescu, Dan; Werge, Thomas; Levy, Deborah L; Josiassen, Richard C; Kennedy, James L; Lieberman, Jeffrey A; Daly, Mark J; Sullivan, Patrick F (2014)
      Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug reaction occurring in up to 1% of ...

    • Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation 

      Cho, Michael Hyosang; Washko, George Richard; Hoffmann, Thomas J; Criner, Gerard J; Hoffman, Eric A; Martinez, Fernando J; Laird, Nan M.; Reilly, John; Silverman, Edwin Kepner (BioMed Central, 2010)
      Background: Numerous studies have demonstrated associations between genetic markers and COPD, but results have been inconsistent. One reason may be heterogeneity in disease definition. Unsupervised learning approaches may ...

    • Clustered risk: An ecological understanding of sexual activity among adolescent boys and girls in two urban slums in Monrovia, Liberia 

      Gausman, Jewel Marie; Lloyd, Danielle; Kallon, Thomas; Subramanian, Sankaran; Langer, Ana Maria; Austin, Sydney Bryn (Elsevier BV, 2019-03)
      Many young people experience sexual debut before they are able to manage risk in order to avoid adverse consequences. Gender norms, social position, and power can undermine an adolescent's ability to exercise agency in ...

    • Clustering of cardiovascular disease risk factors among obese schoolchildren : the Taipei Children Heart Study 

      Chu, N. F.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Wang, D. J.; Liou, H. S.; Shieh, S. M. (Oxford University Press, 1998)
      Background: Childhood obesity increases the risk of obesity in adulthood and is associated with cardiovascular disease (CVD) risk factors such as hypertension, diabetes mellitus, and dyslipidemia. Objective: We evaluated ...

    • CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids 

      Dahlin, Amber; Denny, Joshua; Roden, Dan M.; Brilliant, Murray H.; Ingram, Christie; Kitchner, Terrie E.; Linneman, James G.; Shaffer, Christian M.; Weeke, Peter; Xu, Hua; Kubo, Michiaki; Tamari, Mayumi; Clemmer, George L.; Ziniti, John; McGeachie, Michael J.; Tantisira, Kelan G.; Weiss, Scott T.; Wu, Ann Chen (John Wiley and Sons Inc., 2015)
      Abstract Inhaled corticosteroids (ICS) are the most effective controller medications for asthma, and variability in ICS response is associated with genetic variation. Despite ICS treatment, some patients with poor asthma ...

    • Co-Operative Additive Effects between HLA Alleles in Control of HIV-1 

      Matthews, Philippa C.; Listgarten, Jennifer; Carlson, Jonathan M.; Payne, Rebecca; Huang, Kuan-Hsiang Gary; Frater, John; Goedhals, Dominique; Steyn, Dewald; van Vuuren, Cloete; Paioni, Paolo; Jooste, Pieter; Ogwu, Anthony; Shapiro, Roger L.; Mncube, Zenele; Ndung'u, Thumbi; Walker, Bruce David; Heckerman, David; Goulder, Philip J. R. (Public Library of Science, 2012)
      Background: HLA class I genotype is a major determinant of the outcome of HIV infection, and the impact of certain alleles on HIV disease outcome is well studied. Recent studies have demonstrated that certain HLA class I ...

    • Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins 

      Richard, Jonathan; Pacheco, Beatriz; Gohain, Neelakshi; Veillette, Maxime; Ding, Shilei; Alsahafi, Nirmin; Tolbert, William D.; Prévost, Jérémie; Chapleau, Jean-Philippe; Coutu, Mathieu; Jia, Manxue; Brassard, Nathalie; Park, Jongwoo; Courter, Joel R.; Melillo, Bruno; Martin, Loïc; Tremblay, Cécile; Hahn, Beatrice H.; Kaufmann, Daniel E.; Wu, Xueling; Smith, Amos B.; Sodroski, Joseph; Pazgier, Marzena; Finzi, Andrés (Elsevier, 2016)
      Human immunodeficiency virus type 1 (HIV-1) has evolved a sophisticated strategy to conceal conserved epitopes of its envelope glycoproteins (Env) recognized by antibody-dependent cellular cytotoxicity (ADCC)-mediating ...

    • Codynamics of Four Variables Involved in Dengue Transmission and Its Control by Community Intervention: A System of Four Difference Equations 

      Awerbuch, Tamara Eugenia; Levins, Richard; Predescu, M. (Hindawi Publishing Corporation, 2014)
      In the case of Dengue transmission and control, the interaction of nature and society is captured by a system of difference equations. For the purpose of studying the dynamics of these interactions, four variables involved ...

    • Coffee Consumption and Incidence of Colorectal Cancer in Two Prospective Cohort Studies of Swedish Women and Men 

      Larsson, Susanna C.; Bergkvist, Leif; Giovannucci, Edward; Wolk, Alicja (Oxford University Press, 2006)
      Investigators have reported an inverse association between coffee consumption and risk of colorectal cancer in several case-control studies, but prospective studies, most of them involving small numbers of cases, have not ...

    • Coffee Consumption and Prostate Cancer Risk and Progression in the Health Professionals Follow-up Study 

      Wilson, Kathryn M.; Kasperzyk, Julie L.; Rider, Jennifer R.; Kenfield, Stacey; Dam, Rob van; Stampfer, Meir; Giovannucci, Edward; Mucci, Lorelei A. (Oxford University Press, 2011)
      Background Coffee contains many biologically active compounds, including caffeine and phenolic acids, that have potent antioxidant activity and can affect glucose metabolism and sex hormone levels. Because of these biological ...

    • Coffee Consumption and Risk for Type 2 Diabetes Mellitus 

      Salazar-Martinez, Eduardo; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Ascherio, Alberto; Manson, JoAnn E.; Leitzmann, Michael F.; Stampfer, Meir; Hu, Frank B. (American College of Physicians, 2004)

    • Coffee Consumption and Risk of Cardiovascular Diseases and All-Cause Mortality Among Men With Type 2 Diabetes 

      Zhang, Weili; Lopez-Garcia, Esther; Li, Tricia Y.; Hu, Frank B.; van Dam, Rob M. (American Diabetes Association, 2009)
      OBJECTIVE: Coffee consumption has been linked to detrimental acute metabolic and hemodynamic effects. We investigated coffee consumption in relation to risk of CVDs and mortality in diabetic men. RESEARCH DESIGN AND METHODS: ...

    • Coffee Consumption and Risk of Myocardial Infarction among Older Swedish Women 

      Rosner, Sarah; Åkesson, Agneta; Stampfer, Meir; Wolk, Alicja (Oxford University Press, 2007)
      Numerous studies have examined the association between coffee consumption and risk of myocardial infarction (MI), but results have been inconsistent. Case-control studies generally suggest a harmful effect of coffee drinking, ...

    • Coffee consumption and the risk of overall and fatal prostate cancer in the NIH-AARP Diet and Health study 

      Bosire, Claire; Stampfer, Meir; Subar, Amy F.; Wilson, Kathryn M.; Park, Yikyung; Sinha, Rashmi (Springer (part of Springer Nature), 2013)
      Evidence on the association between coffee consumption and prostate cancer risk is inconsistent; furthermore, few studies have examined the relationship between coffee consumption and fatal prostate cancer. The aim of this ...

    • Coffee consumption and total mortality: a meta-analysis of twenty prospective cohort studies 

      Je, Youjin; Giovannucci, Edward (Cambridge University Press, 2014)
      Coffee consumption has been shown to be associated with various health outcomes, but no comprehensive review and meta-analysis of the association between coffee consumption and total mortality has been conducted. To ...