Browsing SPH Scholarly Articles by Title

Now showing items 1286-1305 of 6362

    • A Comprehensive Map of Insulator Elements for the Drosophila Genome 

      Nègre, Nicolas; Kheradpour, Pouya; Morrison, Carolyn A.; Henikoff, Jorja G.; Feng, Xin; Ahmad, Kami; Stein, Lincoln; Henikoff, Steven; White, Kevin P.; Brown, Christopher D.; Shah, Parantu; Russell, Steven; White, Robert A. H.; Kellis, Manolis (Public Library of Science, 2010)
      Insulators are DNA sequences that control the interactions among genomic regulatory elements and act as chromatin boundaries. A thorough understanding of their location and function is necessary to address the complexities ...

    • A Comprehensive Meta-analysis on Evidence of Mediterranean Diet and Cardiovascular Disease: Are Individual Components Equal? 

      Grosso, Giuseppe; Marventano, Stefano; Yang, Justin J.; Micek, Agnieszka; Pajak, Andrzej; Scalfi, Luca; Galvano, Fabio; Kales, Stephen Nicholas (Informa UK Limited, 2015)
      Many studies have reported that higher adherence to Mediterranean diet may decrease cardiovascular disease (CVD) incidence and mortality. We performed a meta-analysis to explore the association in prospective studies and ...

    • A comprehensive promoter landscape identifies a novel promoter for CD133 in restricted tissues, cancers, and stem cells 

      Sompallae, Ramakrishna; Hofmann, Oliver; Maher, Christopher A.; Gedye, Craig; Behren, Andreas; Vitezic, Morana; Daub, Carsten O.; Devalle, Sylvie; Caballero, Otavia L.; Carninci, Piero; Hayashizaki, Yoshihide; Lawlor, Elizabeth R.; Cebon, Jonathan; Hide, Winston (Frontiers Media S.A., 2013)
      PROM1 is the gene encoding prominin-1 or CD133, an important cell surface marker for the isolation of both normal and cancer stem cells. PROM1 transcripts initiate at a range of transcription start sites (TSS) associated ...

    • Comprehensive Transgender Healthcare: The Gender Affirming Clinical and Public Health Model of Fenway Health 

      Reisner, Sari L.; Bradford, Judith; Hopwood, Ruben; Gonzalez, Alex; Makadon, Harvey; Todisco, David; Cavanaugh, Timothy; VanDerwarker, Rodney; Grasso, Chris; Zaslow, Shayne; Boswell, Stephen L.; Mayer, Kenneth (Springer US, 2015)
      This report describes the evolution of a Boston community health center’s multidisciplinary model of transgender healthcare, research, education, and dissemination of best practices. This process began with the development ...

    • A computational approach to chemical etiologies of diabetes 

      Audouze, Karine; Brunak, Søren; Grandjean, Philippe (Nature Publishing Group, 2013)
      Computational meta-analysis can link environmental chemicals to genes and proteins involved in human diseases, thereby elucidating possible etiologies and pathogeneses of non-communicable diseases. We used an integrated ...

    • Computational biology: plus c'est la même chose, plus ça change 

      Huttenhower, Curtis (BioMed Central, 2011)
      A report on the joint 19th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB)/10th Annual European Conference on Computational Biology (ECCB) meetings and the 7th International Society for ...

    • Computational inference of mRNA stability from histone modification and transcriptome profiles 

      Wang, Chengyang; Tian, Rui; Zhao, Qian; Xu, Han; Meyer, Clifford; Li, Cheng; Zhang, Yong; Liu, Xiaole Shirley (Oxford University Press, 2012)
      Histone modifications play important roles in regulating eukaryotic gene expression and have been used to model expression levels. Here, we present a regression model to systematically infer mRNA stability by comparing ...

    • Computational meta'omics for microbial community studies 

      Segata, Nicola; Boernigen, Daniela; Tickle, Timothy L; Morgan, Xochitl C; Garrett, Wendy S; Huttenhower, Curtis (European Molecular Biology Organization, 2013)
      Complex microbial communities are an integral part of the Earth's ecosystem and of our bodies in health and disease. In the last two decades, culture-independent approaches have provided new insights into their structure ...

    • Computational Reconstruction of NFκB Pathway Interaction Mechanisms during Prostate Cancer 

      Börnigen, Daniela; Tyekucheva, Svitlana; Wang, Xiaodong; Rider, Jennifer R.; Lee, Gwo-Shu; Mucci, Lorelei A.; Sweeney, Christopher; Huttenhower, Curtis (Public Library of Science, 2016)
      Molecular research in cancer is one of the largest areas of bioinformatic investigation, but it remains a challenge to understand biomolecular mechanisms in cancer-related pathways from high-throughput genomic data. This ...

    • Computer Model Challenges Breast Cancer Treatment Strategy 

      Retsky, Michael W.; Swartzendruber, Douglas E.; Bame, Paul D.; Wardwell, Robert H. (Informa UK Limited, 1994)
      The breast cancer treatment failure rate remains unacceptably high. The current breast cancer treatment paradigm, based primarily on Gompertzian kinetics and animal models, advocates short-course, intensive chemotherapy ...

    • Concentrated Ambient Particles Alter Myocardial Blood Flow During Acute Ischemia in Conscious Canines 

      Bartoli, Carlo R.; Wellenius, Gregory A.; Coull, Brent Andrew; Akiyama, Ichiro; Diaz, Edgar; Lawrence, Joy E.; Okabe, Kazunori; Verrier, Richard Leonard; Godleski, John Joseph (National Institute of Environmental Health Sciences, 2008)
      Background: Experimental and observational studies have demonstrated that short-term exposure to ambient particulate matter (PM) exacerbates myocardial ischemia. Objectives: We conducted this study to investigate the effects ...

    • The Concentration-Response Relation Between PM\(_{2.5}\) and Daily Deaths. 

      Schwartz, Joel David; Laden, Francine; Zanobetti, Antonella (National Institute of Environmental Health Sciences, 2002)
      Particulate air pollution at commonly occurring concentrations is associated with daily deaths. Recent attention has focused on the shape of the concentration-response curve, particularly at low doses. Several recent ...

    • Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition 

      Rohrmann, S; Grote, V A; Becker, S; Rinaldi, S; Tjønneland, A; Roswall, N; Grønbæk, H; Overvad, K; Boutron-Ruault, M C; Clavel-Chapelon, F; Racine, A; Teucher, B; Boeing, H; Drogan, D; Dilis, V; Lagiou, Pagona; Trichopoulou, A; Palli, D; Tagliabue, G; Tumino, R; Vineis, P; Mattiello, A; Rodríguez, L; Duell, E J; Molina-Montes, E; Dorronsoro, M; Huerta, J-M; Ardanaz, E; Jeurnink, S; Peeters, P H M; Lindkvist, B; Johansen, D; Sund, M; Ye, W; Khaw, K-T; Wareham, N J; Allen, N E; Crowe, F L; Fedirko, V; Jenab, M; Michaud, D S; Norat, T; Riboli, E; Bueno-de-Mesquita, H B; Kaaks, R (Nature Publishing Group, 2012)
      Background: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation and apoptosis, and may have a role in the aetiology of various cancers. Information on their role ...

    • Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later 

      Fängström, Britta; Hovander, Lotta; Bignert, Anders; Athanassiadis, Ioannis; Linderholm, Linda; Grandjean, Philippe; Weihe, Pal; Bergman, Åke (American Chemical Society (ACS), 2005)
      The objective of this study was to assess blood concentrations of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs), and their polychlorobiphenylol (OH-PCB) metabolites in humans with a high seafood ...

    • Concept, Design and Implementation of a Cardiovascular Gene-centric 50 K SNP Array for Large-scale Genomic Association Studies 

      Keating, Brendan J.; Tischfield, Sam; Murray, Sarah S.; Bhangale, Tushar; Price, Thomas S.; Glessner, Joseph T.; Galver, Luana; Barrett, Jeffrey C.; Grant, Struan F. A.; Farlow, Deborah N.; Chandrupatla, Hareesh R.; Ajmal, Saad; Papanicolaou, George J.; Guo, Yiran; Li, Mingyao; DerOhannessian, Stephanie; Bailey, Swneke D.; Montpetit, Alexandre; Edmondson, Andrew C.; Taylor, Kent; Gai, Xiaowu; Wang, Susanna S.; Fornage, Myriam; Shaikh, Tamim; Groop, Leif; Boehnke, Michael; Hall, Alistair S.; Hattersley, Andrew T.; Frackelton, Edward; Patterson, Nick; Chiang, Charleston W. K.; Kim, Cecelia E.; Fabsitz, Richard R.; Ouwehand, Willem; Munroe, Patricia; Caulfield, Mark; Drake, Thomas; Boerwinkle, Eric; Whitehead, A. Stephen; Cappola, Thomas P.; Samani, Nilesh J.; Lusis, A. Jake; Schadt, Eric; Wilson, James G.; Koenig, Wolfgang; McCarthy, Mark I.; Kathiresan, Sekar; Gabriel, Stacey B.; Hakonarson, Hakon; Anand, Sonia S.; Reilly, Muredach; Engert, James C.; Nickerson, Deborah A.; Rader, Daniel J.; FitzGerald, Garret A.; Reitsma, Pieter H.; Hansen, Mark; de Bakker, Paul I Wen; Price, Alkes; Reich, David Emil; Hirschhorn, Joel Naom (Public Library of Science, 2008)
      A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies ...

    • Conceptual and institutional gaps: understanding how the WHO can become a more effective cross-sectoral collaborator 

      Gopinathan, Unni; Watts, Nicholas; Hougendobler, Daniel; Lefebvre, Alex; Cheung, Arthur; Hoffman, Steven J.; Røttingen, John-Arne (BioMed Central, 2015)
      Background: Two themes consistently emerge from the broad range of academics, policymakers and opinion leaders who have proposed changes to the World Health Organization (WHO): that reform efforts are too slow, and that ...

    • A Conceptual Framework to Measure Systems’ Performance during Emergency Preparedness Exercises 

      Savoia, Elena; Agboola, Foluso; Biddinger, Paul D. (MDPI, 2014)
      Large-scale public health emergencies require a sophisticated, coordinated response involving multiple entities to protect health and minimize suffering. However, the rarity of such emergencies presents a barrier to gathering ...

    • Concerning RNA-guided gene drives for the alteration of wild populations 

      Esvelt, Kevin M; Smidler, Andrea L; Catteruccia, Flaminia; Church, George M (eLife Sciences Publications, Ltd, 2014)
      Gene drives may be capable of addressing ecological problems by altering entire populations of wild organisms, but their use has remained largely theoretical due to technical constraints. Here we consider the potential for ...

    • Concerns about SARS-CoV-2 evolution should not hold back efforts to expand vaccination 

      Cobey, Sarah; Larremore, Daniel B.; Grad, Yonatan; Lipsitch, Marc (2021)
      When vaccines are in limited supply, expanding the number of people who receive some vaccine can reduce disease and mortality compared to concentrating vaccines in a subset of the population. A corollary of such dose-sparing ...

    • Concomitant Socioeconomic, Behavioral, and Biological Factors Associated with the Disproportionate HIV Infection Burden among Black Men Who Have Sex with Men in 6 U.S. Cities 

      Mayer, Kenneth H.; Wang, Lei; Koblin, Beryl; Mannheimer, Sharon; Magnus, Manya; del Rio, Carlos; Buchbinder, Susan; Wilton, Leo; Cummings, Vanessa; Watson, Christopher C.; Piwowar-Manning, Estelle; Gaydos, Charlotte; Eshleman, Susan H.; Clarke, William; Liu, Ting-Yuan; Mao, Cherry; Griffith, Samuel; Wheeler, Darrell (Public Library of Science, 2014)
      Background: American Black men who have sex with men (MSM) are disproportionately affected by HIV, but the factors associated with this concentrated epidemic are not fully understood. Methods: Black MSM were enrolled in 6 ...