Browsing SPH Scholarly Articles by Title
Now showing items 1292-1311 of 6362
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Computational inference of mRNA stability from histone modification and transcriptome profiles
(Oxford University Press, 2012)Histone modifications play important roles in regulating eukaryotic gene expression and have been used to model expression levels. Here, we present a regression model to systematically infer mRNA stability by comparing ... -
Computational meta'omics for microbial community studies
(European Molecular Biology Organization, 2013)Complex microbial communities are an integral part of the Earth's ecosystem and of our bodies in health and disease. In the last two decades, culture-independent approaches have provided new insights into their structure ... -
Computational Reconstruction of NFκB Pathway Interaction Mechanisms during Prostate Cancer
(Public Library of Science, 2016)Molecular research in cancer is one of the largest areas of bioinformatic investigation, but it remains a challenge to understand biomolecular mechanisms in cancer-related pathways from high-throughput genomic data. This ... -
Computer Model Challenges Breast Cancer Treatment Strategy
(Informa UK Limited, 1994)The breast cancer treatment failure rate remains unacceptably high. The current breast cancer treatment paradigm, based primarily on Gompertzian kinetics and animal models, advocates short-course, intensive chemotherapy ... -
Concentrated Ambient Particles Alter Myocardial Blood Flow During Acute Ischemia in Conscious Canines
(National Institute of Environmental Health Sciences, 2008)Background: Experimental and observational studies have demonstrated that short-term exposure to ambient particulate matter (PM) exacerbates myocardial ischemia. Objectives: We conducted this study to investigate the effects ... -
The Concentration-Response Relation Between PM\(_{2.5}\) and Daily Deaths.
(National Institute of Environmental Health Sciences, 2002)Particulate air pollution at commonly occurring concentrations is associated with daily deaths. Recent attention has focused on the shape of the concentration-response curve, particularly at low doses. Several recent ... -
Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
(Nature Publishing Group, 2012)Background: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation and apoptosis, and may have a role in the aetiology of various cancers. Information on their role ... -
Concentrations of Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Polychlorobiphenylols in Serum from Pregnant Faroese Women and Their Children 7 Years Later
(American Chemical Society (ACS), 2005)The objective of this study was to assess blood concentrations of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs), and their polychlorobiphenylol (OH-PCB) metabolites in humans with a high seafood ... -
Concept, Design and Implementation of a Cardiovascular Gene-centric 50 K SNP Array for Large-scale Genomic Association Studies
(Public Library of Science, 2008)A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies ... -
Conceptual and institutional gaps: understanding how the WHO can become a more effective cross-sectoral collaborator
(BioMed Central, 2015)Background: Two themes consistently emerge from the broad range of academics, policymakers and opinion leaders who have proposed changes to the World Health Organization (WHO): that reform efforts are too slow, and that ... -
A Conceptual Framework to Measure Systems’ Performance during Emergency Preparedness Exercises
(MDPI, 2014)Large-scale public health emergencies require a sophisticated, coordinated response involving multiple entities to protect health and minimize suffering. However, the rarity of such emergencies presents a barrier to gathering ... -
Concerning RNA-guided gene drives for the alteration of wild populations
(eLife Sciences Publications, Ltd, 2014)Gene drives may be capable of addressing ecological problems by altering entire populations of wild organisms, but their use has remained largely theoretical due to technical constraints. Here we consider the potential for ... -
Concerns about SARS-CoV-2 evolution should not hold back efforts to expand vaccination
(2021)When vaccines are in limited supply, expanding the number of people who receive some vaccine can reduce disease and mortality compared to concentrating vaccines in a subset of the population. A corollary of such dose-sparing ... -
Concomitant Socioeconomic, Behavioral, and Biological Factors Associated with the Disproportionate HIV Infection Burden among Black Men Who Have Sex with Men in 6 U.S. Cities
(Public Library of Science, 2014)Background: American Black men who have sex with men (MSM) are disproportionately affected by HIV, but the factors associated with this concentrated epidemic are not fully understood. Methods: Black MSM were enrolled in 6 ... -
Concomitant Use of Single Antiplatelet Therapy With Edoxaban or Warfarin in Patients With Atrial Fibrillation: Analysis From the ENGAGE AF‐TIMI48 Trial
(John Wiley and Sons Inc., 2016)Background: We studied the concomitant use of single antiplatelet therapy (SAPT) on the efficacy and safety of the anti‐Xa agent edoxaban in patients with atrial fibrillation (AF). Methods and Results: ENGAGE AF‐TIMI 48 ... -
Concordance Between Life Satisfaction and Six Elements of Well-Being Among Respondents to a Health Assessment Survey, HealthPartners Employees, Minnesota, 2011
(Centers for Disease Control and Prevention, 2016)Introduction: We assessed and tracked perceptions of well-being among employees of member companies of HealthPartners, a nonprofit health care provider and health insurance company in Bloomington, Minnesota. The objective ... -
Concordance between self-reported pre-pregnancy body mass index (BMI) and BMI measured at the first prenatal study contact
(BioMed Central, 2016)Background: The 2009 Institute of Medicine (IOM) gestational weight recommendations are tailored to women’s pre-pregnancy body mass index (BMI). Limited evidence exists on methods for estimating women’s pre-pregnancy BMI, ... -
Concordance of gene expression in human protein complexes reveals tissue specificity and pathology
(Oxford University Press, 2013)Disease-causing variants in human genes usually lead to phenotypes specific to only a few tissues. Here, we present a method for predicting tissue specificity based on quantitative deregulation of protein complexes. The ... -
Conditioned to eat while watching television? Low-income caregivers’ perspectives on the role of snacking and television viewing among pre-schoolers
(2016)Objective: Although television (TV) viewing is frequently paired with snacking among young children, little is known about the environment in which caregivers promote this behaviour. We describe low-income pre-schoolers' ...