Now showing items 1440-1459 of 6362

    • Cumulative Lead Dose and Cognitive Function in Adults: A Review of Studies That Measured Both Blood Lead and Bone Lead 

      Shih, Regina A.; Hu, Howard; Weisskopf, Marc G.; Schwartz, Brian Elliott (National Institute of Environmental Health Sciences, 2006)
      Objective: We review empirical evidence for the relations of recent and cumulative lead dose with cognitive function in adults. Data Sources: A systematic search of electronic databases resulted in 21 environmental and ...
    • Cumulative Lead Exposure and Age at Menopause in the Nurses’ Health Study Cohort 

      Eum, Ki-Do; Weisskopf, Marc G.; Nie, Linda H.; Hu, Howard; Korrick, Susan A. (National Institute of Environmental Health Sciences, 2014)
      Background: Early menopause has been associated with many adverse health outcomes, including increased risk of cardiovascular disease morbidity and mortality. Lead has been found to be adversely associated with female ...
    • Cumulative Lead Exposure and Tooth Loss in Men: The Normative Aging Study 

      Arora, Manish; Weuve, Jennifer Lynn; Weisskopf, Marc G.; Sparrow, David; Nie, Huiling; Garcia, Raul I.; Hu, Howard (National Institute of Environmental Health Sciences, 2009)
      Background: Individuals previously exposed to lead remain at risk because of endogenous release of lead stored in their skeletal compartments. However, it is not known if long-term cumulative lead exposure is a risk factor ...
    • Cumulative Risk of Colon Cancer up to Age 70 Years by Risk Factor Status Using Data From the Nurses’ Health Study 

      Wei, Esther K.; Colditz, Graham A.; Giovannucci, Edward L.; Fuchs, Charles S.; Rosner, Bernard A. (Oxford University Press, 2009)
      The authors developed a comprehensive model of colon cancer incidence that allows for nonproportional hazards and accounts for the temporal nature of risk factors. They estimated relative risk based on cumulative incidence ...
    • Cured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: A population based case-control study 

      Liu, Chen-yu; Hsu, Yi-Hsiang; Wu, Ming-Tsang; Pan, Pi-Chen; Ho, Chi-Kung; Su, Li; Xu, Xin; Li, Yi; Christiani, David C. (BMC, 2009)
      Background: Consumption of cured/smoked meat and fish leads to the formation of carcinogenic N-nitroso compounds in the acidic stomach. This study investigated whether consumed cured/smoked meat and fish, the major dietary ...
    • Cutaneous Periumbilical Purpura in Disseminated Strongyloidiasis in Cancer Patients: A Pathognomonic Feature of Potentially Lethal Disease? 

      Salluh, Jorge I. F.; Bozza, Fernando A.; Pinto, Tatiana S.; Toscano, Luisa; Weller, Peter Fahey; Soares, Marcio (FapUNIFESP (SciELO), 2005)
      Cutaneous manifestations in disseminated strongyloidiasis are infrequent but should raise the suspicion for its diagnosis. We retrospectively evaluated the charts of six patients with cancer and a proven diagnosis of ...
    • CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance 

      Chavey, Carine; Lazennec, Gwendal; Lagarrigue, Sylviane; Clapé, Cyrielle; Iankova, Irena; Teyssier, Jacques; Annicotte, Jean-Sébastien; Schmidt, Julien; Mataki, Chikage; Yamamoto, Hiroyasu; Sanches, Rosario; Guma, Anna; Stich, Vladimir; Vitkova, Michaela; Jardin-Watelet, Bénédicte; Renard, Eric; Strieter, Robert; Tuthill, Antoinette; Vidal-Puig, Antonio; Zorzano, Antonio; Langin, Dominique; Fajas, Lluis; Hotamisligil, Gokhan (Elsevier BV, 2009-04)
      We show here high levels of expression and secretion of the chemokine CXC ligand 5 (CXCL5) in the macrophage fraction of white adipose tissue (WAT). Moreover, we find that CXCL5 is dramatically increased in serum of human ...
    • Cyclic AMP Regulation of Protein Lysine Acetylation in Mycobacterium Tuberculosis 

      Lee, Ho Jun; Lang, P. Therese; Fortune, Sarah Merritt; Sassetti, Christopher M.; Alber, Tom (Nature Publishing Group, 2012)
      Protein lysine acetylation networks can regulate central processes such as carbon metabolism and gene expression in bacteria. In Escherichia coli, cyclic-AMP (cAMP) regulates protein lysine acetyltransferase (PAT) activity ...
    • CYP17 Genetic Variation and Risk of Breast and Prostate Cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3) 

      Setiawan, V. W.; Schumacher, F. R.; Haiman, C. A.; Stram, D. O.; Albanes, D.; Altshuler, D.; Berglund, G.; Buring, J.; Calle, E. E.; Clavel-Chapelon, F.; Cox, D. G.; Gaziano, J. M.; Hankinson, S. E.; Hayes, R. B.; Henderson, B. E.; Hirschhorn, J. N.; Hoover, R.; Hunter, D. J.; Kaaks, R.; Kolonel, L. N.; Kraft, P.; Ma, J.; Le Marchand, L.; Linseisen, J.; Lund, E.; Navarro, C.; Overvad, K.; Palli, D.; Peeters, P. H. M.; Pike, M. C.; Riboli, E.; Stampfer, Meir; Thun, M. J.; Travis, R. C.; Trichopoulos, D.; Yeager, M.; Ziegler, R. G.; Feigelson, H. S.; Chanock, S. J. (American Association for Cancer Research, 2007)
      CYP17 encodes cytochrome p450c17 alpha, which mediates activities essential for the production of sex steroids. Common germ line variation in the CYP17 gene has been related to inconsistent results in breast and prostate ...
    • CYP19A1 genetic variation in relation to prostate cancer risk and circulating sex hormone concentrations in men from the Breast and Prostate Cancer Cohort Consortium 

      Travis, Ruth C.; Schumacher, Fredrick; Hirschhorn, Joel N.; Kraft, Peter; Allen, Naomi E.; Albanes, Demetrius; Berglund, Goran; Berndt, Sonja I.; Boeing, Heiner; Bueno-de-Mesquita, H. Bas; Calle, Eugenia E.; Chanock, Stephen; Dunning, Alison M.; Hayes, Richard; Feigelson, Heather Spencer; Gaziano, J. Michael; Giovannucci, Edward; Haiman, Christopher A.; Henderson, Brian E.; Kaaks, Rudolf; Kolonel, Laurence N.; Ma, Jing; Rodriguez, Laudina; Riboli, Elio; Stampfer, Meir; Stram, Daniel O.; Thun, Michael J.; Tjønneland, Anne; Trichopoulos, Dimitrios; Vineis, Paolo; Virtamo, Jarmo; Marchand, Loïc Le; Hunter, David J. (American Association for Cancer Research, 2009)
      Sex hormones, particularly the androgens, are important for the growth of the prostate gland and have been implicated in prostate cancer carcinogenesis, yet the determinants of endogenous steroid hormone levels remain ...
    • CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk 

      Garcia-Albeniz, Xabier; Rudolph, Anja; Hutter, Carolyn; White, Emily; Lin, Yi; Rosse, Stephanie A; Figueiredo, Jane C; Harrison, Tabitha A; Jiao, Shuo; Brenner, Hermann; Casey, Graham; Hudson, Thomas J; Thornquist, Mark; Le Marchand, Loic; Potter, John; Slattery, Martha L; Zanke, Brent; Baron, John A; Caan, Bette J; Chanock, Stephen J; Berndt, Sonja I; Stelling, Deanna; Fuchs, Charles S; Hoffmeister, Michael; Butterbach, Katja; Du, Mengmeng; James Gauderman, W; Gunter, Marc J; Lemire, Mathieu; Ogino, Shuji; Lin, Jennifer; Hayes, Richard B; Haile, Robert W; Schoen, Robert E; Warnick, Greg S; Jenkins, Mark A; Thibodeau, Stephen N; Schumacher, Fredrick R; Lindor, Noralane M; Kolonel, Laurence N; Hopper, John L; Gong, Jian; Seminara, Daniela; Pflugeisen, Bethann M; Ulrich, Cornelia M; Qu, Conghui; Duggan, David; Cotterchio, Michelle; Campbell, Peter T; Carlson, Christopher S; Newcomb, Polly A; Giovannucci, Edward; Hsu, Li; Chan, Andrew T; Peters, Ulrike; Chang-Claude, Jenny (Nature Publishing Group, 2016)
      Background: Menopausal hormone therapy (MHT) use has been consistently associated with a decreased risk of colorectal cancer (CRC) in women. Our aim was to use a genome-wide gene–environment interaction analysis to identify ...
    • Cystatin C and Creatinine in an HIV Cohort: the Nutrition for Healthy Living Study 

      Jones, Clara Y.; Jones, Camille A.; Wilson, Ira B.; Knox, Tamsin A.; Levey, Andrew S.; Spiegelman, Donna; Gorbach, Sherwood L.; Lente, Frederick Van; Stevens, Lesley A. (Elsevier, 2008)
      Background: Human immunodeficiency virus (HIV)-infected persons have an increased risk of chronic kidney disease (CKD). Serum creatinine level may underestimate the prevalence of CKD in subjects with decreased lean body ...
    • Cystatin C-Based Renal Function Changes After Antiretroviral Initiation: A Substudy of a Randomized Trial 

      Gupta, Samir K.; Kitch, Douglas; Tierney, Camlin; Daar, Eric S.; Sax, Paul E.; Melbourne, Kathleen; Ha, Belinda; McComsey, Grace A. (Oxford University Press, 2014)
      Background. The effects of antiretrovirals on cystatin C-based renal function estimates are unknown. Methods. We analyzed changes in renal function using creatinine and cystatin C-based estimating equations in 269 patients ...
    • Cysteinyl leukotrienes acting via granule membrane-expressed receptors elicit secretion from within cell-free human eosinophil granules 

      Neves, Josiane S.; Radke, Amy L.; Weller, Peter Fahey (Elsevier BV, 2010)
      Background—Cysteinyl leukotrienes are recognized to act via receptors (CysLTRs) expressed on cell surface plasma membranes. Agents that block CysLT1R, are therapeutics for allergic disorders. Eosinophils contain multiple ...
    • Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion 

      Spencer, L. A.; Melo, R. C. N.; Perez, S. A. C.; Bafford, S. P.; Dvorak, A. M.; Weller, Peter Fahey (Proceedings of the National Academy of Sciences, 2006)
      Although leukocytes of the innate immune system, including eosinophils, contain within their granules preformed stores of cytokines available for selective and rapid release, little is known about the mechanisms governing ...
    • Cytokine-Dependent and -Independent Gene Expression Changes and Cell Cycle Block revealed in Trypanosoma cruzi-infected Host Cells by Comparative mRNA Profiling 

      Costales, Jaime A; Daily, Johanna P; Burleigh, Barbara (BioMed Central, 2009)
      Background: The requirements for growth and survival of the intracellular pathogen Trypanosoma cruzi within mammalian host cells are poorly understood. Transcriptional profiling of the host cell response to infection serves ...
    • Cytoplasmic Polyadenylation Element Binding Protein Deficiency Stimulates PTEN and Stat3 mRNA Translation and Induces Hepatic Insulin Resistance 

      Alexandrov, Ilya M.; Ivshina, Maria; Jung, Dae Young; Friedline, Randall; Ko, Hwi Jin; Xu, Mei; O'Sullivan-Murphy, Bryan; Bortell, Rita; Huang, Yen-Tsung; Urano, Fumihiko; Kim, Jason Hwan; Richter, Joel D. (Public Library of Science, 2012)
      The cytoplasmic polyadenylation element binding protein CPEB1 (CPEB) regulates germ cell development, synaptic plasticity, and cellular senescence. A microarray analysis of mRNAs regulated by CPEB unexpectedly showed that ...
    • A Cytosine Methytransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen 

      Chao, Michael C.; Zhu, Shijia; Kimura, Satoshi; Davis, Brigid M.; Schadt, Eric E.; Fang, Gang; Waldor, Matthew K. (Public Library of Science, 2015)
      DNA methylation is a key epigenetic regulator in all domains of life, yet the effects of most bacterial DNA methyltransferases on cellular processes are largely undefined. Here, we used diverse techniques, including bisulfite ...
    • Daily Zinc but Not Multivitamin Supplementation Reduces Diarrhea and Upper Respiratory Infections in Tanzanian Infants: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial 

      McDonald, Christine; Manji, Karim; Kisenge, Rodrick; Aboud, Said; Spiegelman, Donna; Fawzi, Wafaie; Duggan, Christopher (Oxford University Press, 2015)
      Background: Although various micronutrient regimens have been shown to prevent and treat common infectious diseases in children, the effects of daily multivitamin (MV) and/or zinc supplementation have not been widely ...
    • Dairy calcium intake, serum vitamin D, and successful weight loss 

      Shahar, D. R.; Schwarzfuchs, D.; Fraser, D.; Vardi, H.; Thiery, J.; Fiedler, G. M.; Bluher, M.; Stumvoll, M.; Stampfer, Meir; Shai, I. (Oxford University Press, 2010)
      Background The role 01 dairy calcium intake and scrum vitamin D concentrations in weight loss is controversialObjective The objective was to assess the association of dairy calcium intake and serum vitamin D with weight ...