Browsing SPH Scholarly Articles by Title
Now showing items 1784-1803 of 6362
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Dormancy and surgery-driven escape from dormancy help explain some clinical features of breast cancer
(Wiley-Blackwell, 2008)To explain bimodal relapse patterns observed in breast cancer data, we have proposed that metastatic breast cancer growth commonly includes periods of temporary dormancy at both the single cell phase and the avascular ... -
Dose-Dependent Mutation Rates Determine Optimum Erlotinib Dosing Strategies for EGFR Mutant Non-Small Cell Lung Cancer Patients
(Public Library of Science, 2015)Background: The advent of targeted therapy for cancer treatment has brought about a paradigm shift in the clinical management of human malignancies. Agents such as erlotinib used for EGFR-mutant non-small cell lung cancer ... -
Dose–response relationship between sports activity and musculoskeletal pain in adolescents
(Wolters Kluwer, 2016)Abstract Physical activity has multiple health benefits but may also increase the risk of developing musculoskeletal pain (MSP). However, the relationship between physical activity and MSP has not been well characterized. ... -
Dose–Response Relationship of Prenatal Mercury Exposure and IQ: An Integrative Analysis of Epidemiologic Data
(National Institute of Environmental Health Sciences, 2007)Background: Prenatal exposure to mercury has been associated with adverse childhood neurologic outcomes in epidemiologic studies. Dose–response information for this relationship is useful for estimating benefits of reduced ... -
Double-Jeopardy: The Joint Impact of Neighborhood Disadvantage and Low Social Cohesion on Cumulative Risk of Disease Among African American Men and Women in the Jackson Heart Study
(2016)Objectives: Few studies have examined the joint impact of neighborhood disadvantage and low social cohesion on health. Moreover, no study has considered the joint impact of these factors on a cumulative disease risk profile ... -
Downwind from the Great Tohoku Earthquake: A Call to Global Action
(Department of Emergency Medicine, University of California, Irvine, 2011) -
Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
(MyJove Corporation, 2014)Biomarkers are directly-measured biological indicators of disease, health, exposures, or other biological information. In population and social sciences, biomarkers need to be easy to obtain, transport, and analyze. Dried ... -
Drinking frequency and quantity and risk of suicide among men
(2007)Background Individuals who die from suicide commonly have consumed alcohol immediately beforehand, often in large quantities. However, prospective cohort data on regular alcohol use as a risk factor for suicide are lacking. ... -
Driving a decade of change: HIV/AIDS, patents and access to medicines for all
(Wiley, 2011)Since 2000, access to antiretroviral drugs to treat HIV infection has dramatically increased to reach more than five million people in developing countries. Essential to this achievement was the dramatic reduction in ... -
Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug
(Oxford University Press, 2012)Plasmodium parasites undergo a clinically silent and obligatory developmental phase in the host’s liver cells before they are able to infect erythrocytes and cause malaria symptoms. To overcome the scarcity of compounds ... -
Drug Use and Other Risk Factors Related to Lower Body Mass Index among HIV-Infected Individuals
(Elsevier, 2008)Malnutrition is associated with morbidity and mortality in HIV-infected individuals. Little research has been conducted to identify the roles that clinical, illicit drug use and socioeconomic characteristics play in the ... -
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval
(2013)Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the “missing heritability” of complex traits. Here, we describe four independent analyses ... -
Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeast
(Proceedings of the National Academy of Sciences, 1997)Sequence divergence acts as a potent barrier to homologous recombination; much of this barrier derives from an antirecombination activity exerted by mismatch repair proteins. An inverted repeat assay system with recombination ... -
Duration and breaks in sedentary behaviour: accelerometer data from 1566 community-dwelling older men (British Regional Heart Study)
(BMJ Publishing Group, 2015)Background: Sedentary behaviours are increasingly recognised as raising the risk of cardiovascular disease events, diabetes and mortality, independently of physical activity levels. However, little is known about patterns ... -
Duration of Lactation and Maternal Adipokines at 3 Years Postpartum
(American Diabetes Association, 2011)Objective: Lactation has been associated with reduced maternal risk of type 2 diabetes, the metabolic syndrome, and cardiovascular disease. We examined the relationship between breastfeeding duration and maternal adipokines ... -
Dynamic denominators: the impact of seasonally varying population numbers on disease incidence estimates
(BioMed Central, 2016)Background: Reliable health metrics are crucial for accurately assessing disease burden and planning interventions. Many health indicators are measured through passive surveillance systems and are reliant on accurate ... -
Dynamic Eye Tracking Based Metrics for Infant Gaze Patterns in the Face-Distractor Competition Paradigm
(Public Library of Science, 2014)Objective: To develop new standardized eye tracking based measures and metrics for infants’ gaze dynamics in the face-distractor competition paradigm. Method Eye tracking data were collected from two samples of healthy ... -
Dynamic Parameters of Balance Which Correlate to Elderly Persons with a History of Falls
(Public Library of Science, 2013)Poor balance in older persons contributes to a rise in fall risk and serious injury, yet no consensus has developed on which measures of postural sway can identify those at greatest risk of falling. Postural sway was ... -
Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies
(Elsevier BV, 2019-05)Large-scale whole genome sequencing (WGS) studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests (RVATs) have limited scope to leverage variant ... -
Dynamics and Frequency of Gag Transmitted Polymorphisms in Zambia
(BioMed Central, 2012)