Browsing SPH Scholarly Articles by Title

Now showing items 1791-1810 of 6362

    • Drinking frequency and quantity and risk of suicide among men 

      Mukamal, Kenneth J.; Kawachi, Ichiro; Miller, Matthew; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600 (2007)
      Background Individuals who die from suicide commonly have consumed alcohol immediately beforehand, often in large quantities. However, prospective cohort data on regular alcohol use as a risk factor for suicide are lacking. ...

    • Driving a decade of change: HIV/AIDS, patents and access to medicines for all 

      Hoen, Ellen; Berger, Jonathan; Calmy, Alexandra; Moon, Suerie (Wiley, 2011)
      Since 2000, access to antiretroviral drugs to treat HIV infection has dramatically increased to reach more than five million people in developing countries. Essential to this achievement was the dramatic reduction in ...

    • Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug 

      da Cruz, Filipa P.; Martin, Cécilie; Lafuente-Monasterio, Maria J.; Rodrigues, Tiago; Sönnichsen, Birte; Moreira, Rui; Gamo, Francisco-Javier; Hannus, Michael; Prudêncio, Miguel; Buchholz, Kathrin; Marti, Matthias; Mota, Maria (Oxford University Press, 2012)
      Plasmodium parasites undergo a clinically silent and obligatory developmental phase in the host’s liver cells before they are able to infect erythrocytes and cause malaria symptoms. To overcome the scarcity of compounds ...

    • Drug Use and Other Risk Factors Related to Lower Body Mass Index among HIV-Infected Individuals 

      Quach, Lien; Wanke, Christine; Schmid, Christopher; Gorbach, Sherwood; Mwamburi, D. Mkaya; Mayer, Kenneth; Spiegelman, Donna; Tang, Alice (Elsevier, 2008)
      Malnutrition is associated with morbidity and mortality in HIV-infected individuals. Little research has been conducted to identify the roles that clinical, illicit drug use and socioeconomic characteristics play in the ...

    • Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval 

      Avery, Christy L.; Sitlani, Colleen M.; Arking, Dan E.; Arnett, Donna K.; Bis, Joshua C.; Boerwinkle, Eric; Buckley, Brendan M.; Chen, Y.-D. Ida; de Craen, Anton JM; Eijgelsheim, Mark; Enquobahrie, Daniel; Evans, Daniel S.; Ford, Ian; Garcia, Melissa E.; Gudnason, Vilmundur; Harris, Tamara B.; Heckbert, Susan R.; Hochner, Hagit; Hofman, Albert; Hsueh, Wen-Chi; Isaacs, Aaron; Jukema, J. Wouter; Knekt, Paul; Kors, Jan A.; Krijthe, Bouwe P.; Kristiansson, Kati; Laaksonen, Maarit; Liu, Yongmei; Li, Xiaohui; MacFarlane, Peter W.; Newton-Cheh, Christopher; Nieminen, Markku S.; Oostra, Ben A.; Peloso, Gina M.; Porthan, Kimmo; Rice, Kenneth; Rivadeneira, Fernando F.; Rotter, Jerome I.; Salomaa, Veikko; Sattar, Naveed; Siscovick, David S.; Slagboom, P. Eline; Smith, Albert V.; Sotoodehnia, Nona; Stott, David J.; Stricker, Bruno H.; Stürmer, Til; Trompet, Stella; Uitterlinden, Andre G.; van Duijn, Cornelia M.; Westendorp, Rudi GJ; Witteman, Jacqueline C.; Whitsel, Eric A.; Psaty, Bruce M. (2013)
      Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the “missing heritability” of complex traits. Here, we describe four independent analyses ...

    • Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeast 

      Abhijit, Datta; Hendrix, Miyono; Lipsitch, Marc; Jinks-Robertson, Sue (Proceedings of the National Academy of Sciences, 1997)
      Sequence divergence acts as a potent barrier to homologous recombination; much of this barrier derives from an antirecombination activity exerted by mismatch repair proteins. An inverted repeat assay system with recombination ...

    • Duration and breaks in sedentary behaviour: accelerometer data from 1566 community-dwelling older men (British Regional Heart Study) 

      Jefferis, Barbara J; Sartini, Claudio; Shiroma, Eric; Whincup, Peter H; Wannamethee, S Goya; Lee, I-Min (BMJ Publishing Group, 2015)
      Background: Sedentary behaviours are increasingly recognised as raising the risk of cardiovascular disease events, diabetes and mortality, independently of physical activity levels. However, little is known about patterns ...

    • Duration of Lactation and Maternal Adipokines at 3 Years Postpartum 

      Stuebe, Alison M.; Mantzoros, Christos; Kleinman, Ken Paul; Gillman, Matthew William; Rifas-Shiman, Sheryl Lynn; Gunderson, Erica P.; Rich-Edwards, Janet Wilson (American Diabetes Association, 2011)
      Objective: Lactation has been associated with reduced maternal risk of type 2 diabetes, the metabolic syndrome, and cardiovascular disease. We examined the relationship between breastfeeding duration and maternal adipokines ...

    • Dynamic denominators: the impact of seasonally varying population numbers on disease incidence estimates 

      zu Erbach-Schoenberg, Elisabeth; Alegana, Victor A.; Sorichetta, Alessandro; Linard, Catherine; Lourenço, Christoper; Ruktanonchai, Nick W.; Graupe, Bonita; Bird, Tomas J.; Pezzulo, Carla; Wesolowski, Amy; Tatem, Andrew J. (BioMed Central, 2016)
      Background: Reliable health metrics are crucial for accurately assessing disease burden and planning interventions. Many health indicators are measured through passive surveillance systems and are reliant on accurate ...

    • Dynamic Eye Tracking Based Metrics for Infant Gaze Patterns in the Face-Distractor Competition Paradigm 

      Ahtola, Eero; Stjerna, Susanna; Yrttiaho, Santeri; Nelson, Charles A.; Leppänen, Jukka M.; Vanhatalo, Sampsa (Public Library of Science, 2014)
      Objective: To develop new standardized eye tracking based measures and metrics for infants’ gaze dynamics in the face-distractor competition paradigm. Method Eye tracking data were collected from two samples of healthy ...

    • Dynamic Parameters of Balance Which Correlate to Elderly Persons with a History of Falls 

      Muir, Jesse W.; Kiel, Douglas P.; Hannan, Marian; Magaziner, Jay; Rubin, Clinton T. (Public Library of Science, 2013)
      Poor balance in older persons contributes to a rise in fall risk and serious injury, yet no consensus has developed on which measures of postural sway can identify those at greatest risk of falling. Postural sway was ...

    • Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies 

      Li, Zilin; Li, Xihao; Liu, Yaowu; Shen, Jincheng; Chen, Han; Zhou, Hufeng; Morrison, Alanna C.; Boerwinkle, Eric; Lin, Xihong (Elsevier BV, 2019-05)
      Large-scale whole genome sequencing (WGS) studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests (RVATs) have limited scope to leverage variant ...

    • Dynamics and Frequency of Gag Transmitted Polymorphisms in Zambia 

      Claiborne, D; Kilembe, W; Ndung'u, T; Frater, J; Kaslow, R; Allen, S; Goepfert, P; Heckerman, D; Hunter, E; Schaefer, M; Carlson, J; Prince, J; Tang, J; Farmer, P; Shapiro, Roger L.; Goulder, P (BioMed Central, 2012)

    • Dynamics of Immune Reconstitution and Activation Markers in HIV+ Treatment-Naïve Patients Treated with Raltegravir, Tenofovir Disoproxil Fumarate and Emtricitabine 

      Funderburg, Nicholas T.; Andrade, Adriana; Chan, Ellen S.; Rosenkranz, Susan L.; Lu, Darlene; Clagett, Brian; Pilch-Cooper, Heather A.; Rodriguez, Benigno; Feinberg, Judith; Daar, Eric; Mellors, John; Kuritzkes, Daniel; Jacobson, Jeffrey M.; Lederman, Michael M. (Public Library of Science, 2013)
      Background: The dynamics of CD4+ T cell reconstitution and changes in immune activation and inflammation in HIV-1 disease following initiation of antiretroviral therapy (ART) are incompletely defined and their underlying ...

    • Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease 

      Shaw, Kelly A.; Bertha, Madeline; Hofmekler, Tatyana; Chopra, Pankaj; Vatanen, Tommi; Srivatsa, Abhiram; Prince, Jarod; Kumar, Archana; Sauer, Cary; Zwick, Michael E.; Satten, Glen A.; Kostic, Aleksandar D.; Mulle, Jennifer G.; Xavier, Ramnik J.; Kugathasan, Subra (BioMed Central, 2016)
      Background: Gut microbiome dysbiosis has been demonstrated in subjects with newly diagnosed and chronic inflammatory bowel disease (IBD). In this study we sought to explore longitudinal changes in dysbiosis and ascertain ...

    • Dysfunction of the Intestinal Microbiome in Inflammatory Bowel Disease and Treatment 

      Morgan, Xochitl C; Sokol, Harry; Gevers, Dirk; Ward, Doyle V; LeLeiko, Neal; Sands, Bruce E; Tickle, Timothy L.; Devaney, Kathryn L; Reyes, Joshua Anthony; Shah, Samir A; Snapper, Scott Brian; Bousvaros, Athos; Korzenik, Joshua; Xavier, Ramnik; Huttenhower, Curtis (BioMed Central, 2012)
      Background: The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis result from alterations in intestinal microbes and the immune system. However, the precise dysfunctions of microbial metabolism in ...

    • Dysfunctional HDL and progression of atherosclerosis in HIV-1-infected and -uninfected adults 

      Kelesidis, Theodoros; Yang, Otto O; Kendall, Michelle Anne; Hodis, Howard N; Currier, Judith S (BioMed Central, 2013)
      Background: HDL function rather than absolute level may be a more accurate indicator for risk of developing atherosclerosis. Dysfunctional HDL has increased redox activity and reduced antioxidant properties, but it is ...

    • Dyslipidemia and the Risk of Incident Hypertension in Men 

      Halperin, R. O.; Sesso, H. D.; Ma, J.; Buring, J. E.; Stampfer, Meir; Michael Gaziano, J. (American Heart Association, 2005)
      Evidence suggests that hypertension may share a similar pathophysiology with cardiovascular disease (CVD). Thus, dyslipidemia, a strong predictor of CVD, may also predict incident hypertension. We analyzed 3110 men free ...

    • Dyslipidemia in an HIV-Positive Antiretroviral Treatment-Naive Population in Dar es Salaam, Tanzania 

      Armstrong, Catharina; Liu, Enju; Okuma, James; Spiegelman, Donna Lynn; Guerino, Chalamilla; Njelekela, Marina Alois; Grinspoon, Steven Kyle; Fawzi, Wafaie W.; Hawkins, Claudia (Ovid Technologies (Wolters Kluwer Health), 2011)
      Limited data are available on dyslipidemia in HIV-infected patients in resource-limited settings (RLS). We performed a cross-sectional analysis in ART-naïve, non-fasting HIV-infected patients in Tanzania between November ...

    • The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids 

      Hoxhaj, Gerta; Caddye, Edward; Najafov, Ayaz; Houde, Vanessa P; Johnson, Catherine; Dissanayake, Kumara; Toth, Rachel; Campbell, David G; Prescott, Alan R; MacKintosh, Carol (eLife Sciences Publications, Ltd, 2016)
      The mechanistic Target of Rapamycin complex 1 (mTORC1) senses intracellular amino acid levels through an intricate machinery, which includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase). The membrane-associated ...