Browsing SPH Scholarly Articles by Title

Now showing items 2468-2487 of 6362

    • Functional RNA Interference (RNAi) Screen Identifies System a Neutral Amino Acid Transporter 2 (SNAT2) as a Mediator of Arsenic-induced Endoplasmic Reticulum Stress 

      Oh, Raymond S.; Pan, Wen-Chi; Yalcin, Abdullah; Zhang, Hong; Guilarte, Tomás R.; Hotamisligil, Gökhan S.; Christiani, David C.; Lu, Quan (American Society for Biochemistry and Molecular Biology, 2012)
      Exposure to the toxic metalloid arsenic is associated with diabetes and cancer and causes proteotoxicity and endoplasmic reticulum (ER) stress at the cellular level. Adaptive responses to ER stress are implicated in cancer ...

    • Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration 

      Castillo, Valentina; Oñate, Maritza; Woehlbier, Ute; Rozas, Pablo; Andreu, Catherine; Medinas, Danilo; Valdés, Pamela; Osorio, Fabiola; Mercado, Gabriela; Vidal, René L.; Kerr, Bredford; Court, Felipe A.; Hetz, Claudio (Public Library of Science, 2015)
      ERp57 (also known as grp58 and PDIA3) is a protein disulfide isomerase that catalyzes disulfide bonds formation of glycoproteins as part of the calnexin and calreticulin cycle. ERp57 is markedly upregulated in most common ...

    • Functional SNPs in HSPA1A Gene Predict Risk of Coronary Heart Disease 

      He, Meian; Guo, Huan; Yang, Xiaobo; Zhang, Xiaomin; Zhou, Li; Cheng, Longxian; Zeng, Hesong; Hu, Frank B.; Tanguay, Robert M.; Wu, Tangchun (Public Library of Science, 2009)
      Background: HSP70 plays crucial roles in endothelial cell apoptosis, which is involved in the early phase and progress of coronary heart disease (CHD). However, the association between polymorphisms of HSP70 genes and the ...

    • Functionally distinct patterns of nucleosome remodeling at enhancers in glucocorticoid-treated acute lymphoblastic leukemia 

      Wu, Jennifer N.; Pinello, Luca; Yissachar, Elinor; Wischhusen, Jonathan W.; Yuan, Guo-Cheng; Roberts, Charles W. M. (BioMed Central, 2015)
      Background: Precise nucleosome positioning is an increasingly recognized feature of promoters and enhancers, reflecting complex contributions of DNA sequence, nucleosome positioning, histone modification and transcription ...

    • Functionally informed fine-mapping and polygenic localization of complex trait heritability 

      Weissbrod, Omer; Hormozdiari, Farhad; Benner, Christian; Cui, Ran; Ulirsch, Jacob; Gazal, Steven; Schoech, Armin; van de Geijn, Bryce; Reshef, Yakir; Márquez-Luna, Carla; O’Connor, Luke; Pirinen, Matti; Finucane, Hilary; Price, Alkes (Springer Science and Business Media LLC, 2020-11-16)
      Fine-mapping aims to identify causal variants impacting complex traits. We propose PolyFun, a computationally scalable framework to improve fine-mapping accuracy by leveraging functional annotations across the entire ...

    • Fundamental causes of social inequalities in mortality: A test of the theory 

      Phelan, J.; Link, Bruce; Diez-Roux, Ana; Kawachi, Ichiro; Levin, Bruce (American Sociological Association, 2004)
      Medicine and epidemiology currently dominate the study of the strong association between socioeconomic status and mortality. Socioeconomic status typically is viewed as a causally irrelevant "confounding variable" or as a ...

    • Funding gap for immunization across 94 low- and middle-income countries 

      Ozawa, Sachiko; Grewal, Simrun; Portnoy, Allison; Sinha, Anushua; Arilotta, Richard; Stack, Meghan L.; Brenzel, Logan (Elsevier Science, 2016)
      Novel vaccine development and production has given rise to a growing number of vaccines that can prevent disease and save lives. In order to realize these health benefits, it is essential to ensure adequate immunization ...

    • Fungal Levels in the Home and Allergic Rhinitis by 5 Years of Age 

      Stark, Paul C.; Celedón, Juan C.; Chew, Ginger L.; Ryan, Louise Marie; Burge, Harriet A.; Muilenberg, Michael L.; Gold, Diane R. (National Institute of Environmental Health Sciences, 2005)
      Studies have repeatedly demonstrated that sensitization to fungi, such as Alternaria, is strongly associated with allergic rhinitis and asthma in children. However, the role of exposure to fungi in the development of ...

    • Fungus Spores, Air Pollutants, and Other Determinants of Peak Expiratory Flow Rate in Children 

      Neas, L. M.; Burge, H.; Koutrakis, p.; Speizer, F. E.; Dockery, Douglas (Oxford University Press (OUP), 1996-04-15)
      The impact of summertime haze episodes on daily variations in symptoms and peak expiratory flow rates (PEFRs) was examined in a study of 108 children living in State College, Pennsylvania, during the summer of 1991. Twice ...

    • Further Confirmation of Germline Glioma Risk Variant rs78378222 in TP53 and Its Implication in Tumor Tissues via Integrative Analysis of TCGA Data 

      Wang, Zhaoming; Rajaraman, Preetha; Melin, Beatrice; Chung, Charles; Zhang, Weijia; McKean-Cowdin, Roberta; Michaud, Dominique; Yeager, Meredith; Ahlbom, Anders; Albanes, Demetrius; Andersson, Ulrika; Freeman, Laura E. Beane; Buring, Julie; Butler, Mary Ann; Carreón, Tania; Feychting, Maria; Gapstur, Susan; Gaziano, J. Michael; Giles, Graham; Hallmans, Goran; Henriksson, Roger; Hoffman-Bolton, Judith; Inskip, Peter; Kitahara, Cari; Le Marchand, Loic; Linet, Martha; Li, Shengchao; Peters, Ulrike; Purdue, Mark; Rothman, Nathaniel; Ruder, Avima; Sesso, Howard; Severi, Gianluca; Stampfer, Meir; Stevens, Victoria; Visvanathan, Kala; Wang, Sophia; White, Emily; Zeleniuch-Jacquotte, Anne; Hoover, Robert; Fraumeni, Joseph; Chatterjee, Nilanjan; Hartge, Patricia; Chanock, Stephen (Wiley, 2015)
      We confirmed strong association of rs78378222:A>C (per allele odds ratio [OR] = 3.14; P = 6.48 x 10(-11)), a germline rare single-nucleotide polymorphism (SNP) in TP53, via imputation of a genome-wide association study ...

    • Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans 

      Myers, Rachel A.; Himes, Blanca; Gignoux, Christopher R.; Yang, James J.; Gauderman, W. James; Rebordosa, Cristina; Xie, Jianming; Torgerson, Dara G.; Levin, Albert M.; Baurley, James; Graves, Penelope E.; Mathias, Rasika A.; Romieu, Isabelle; Roth, Lindsey A.; Conti, David; Avila, Lydiana; Eng, Celeste; Vora, Hita; LeNoir, Michael A.; Soto-Quiros, Manuel; Liu, Jinghua; Celedón, Juan C.; Farber, Harold J.; Kumar, Rajesh; Avila, Pedro C.; Meade, Kelley; Serebrisky, Denise; Thyne, Shannon; Rodriguez-Cintron, William; Rodriguez-Santana, Jose R.; Borrell, Luisa N.; Lemanske, Robert F.; Bleecker, Eugene R.; Meyers, Deborah A.; London, Stephanie J.; Barnes, Kathleen C.; Raby, Benjamin Alexander; Martinez, Fernando D.; Gilliland, Frank D.; Williams, L. Keoki; Burchard, Esteban G.; Weiss, Scott Tillman; Nicolae, Dan L.; Ober, Carole (Elsevier BV, 2012)
      Background: Genome-wide association studies of asthma have implicated many genetic risk factors, with well-replicated associations at approximately 10 loci that account for only a small proportion of the genetic ...

    • Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis 

      Mima, Kosuke; Nishihara, Reiko; Qian, Zhi Rong; Cao, Yin; Sukawa, Yasutaka; Nowak, Jonathan; Yang, Juhong; Dou, Ruoxu; Masugi, Yohei; Song, Mingyang; Kostic, Aleksandar; Giannakis, Marios; Bullman, Susan; Milner, Danny; Baba, Hideo; Giovannucci, Edward; Garraway, Levi; Freeman, Gordon; Dranoff, Glenn; Garrett, Wendy; Huttenhower, Curtis; Meyerson, Matthew; Meyerhardt, Jeffrey; Chan, Andrew; Fuchs, Charles; Ogino, Shuji (BMJ Publishing Group, 2016)
      Objective Accumulating evidence links the intestinal microbiota and colorectal carcinogenesis. Fusobacterium nucleatum may promote colorectal tumour growth and inhibit T cell-mediated immune responses against colorectal ...

    • The future of food from the sea 

      Costello, Christopher; Cao, Ling; Gelcich, Stefan; Cisneros-Mata, Miguel Á.; Free, Christopher M.; Froehlich, Halley E.; Golden, Christopher; Ishimura, Gakushi; Maier, Jason; Macadam-Somer, Ilan; Mangin, Tracey; Melnychuk, Michael C.; Miyahara, Masanori; de Moor, Carryn L.; Naylor, Rosamond; Nøstbakken, Linda; Ojea, Elena; O’Reilly, Erin; Parma, Ana M.; Plantinga, Andrew J.; Thilsted, Shakuntala H.; Lubchenco, Jane (Springer Science and Business Media LLC, 2020-08-19)
      <jats:title>Abstract</jats:title><jats:p>Global food demand is rising, and serious questions remain about whether supply can increase sustainably (FAO 2018). Land-based expansion is possible but may exacerbate climate ...

    • The Future of Japan's Health System — Sustaining Good Health with Equity at Low Cost 

      Reich, Michael Robin; Shibuya, Kenji (New England Journal of Medicine (NEJM/MMS), 2015)

    • Future trends in environmental mercury concentrations: implications for prevention strategies 

      Sunderland, Elsie M; Selin, Noelle E (BioMed Central, 2013)
      In their new paper, Bellanger and coauthors show substantial economic impacts to the EU from neurocognitive impairment associated with methylmercury (MeHg) exposures. The main source of MeHg exposure is seafood consumption, ...

    • Fuzzy species revisited 

      Hanage, William P. (BioMed Central, 2013)

    • Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis 

      Coste, B.; Houge, G.; Murray, M. F.; Stitziel, N.; Bandell, M.; Giovanni, M. A.; Philippakis, A.; Hoischen, A.; Riemer, G.; Steen, U.; Steen, V. M.; Mathur, J.; Cox, J.; Lebo, M.; Rehm, H.; Weiss, Scott Tillman; Wood, J. N.; Maas, R. L.; Sunyaev, Shamil R.; Patapoutian, A. (Proceedings of the National Academy of Sciences, 2013)
      Mechanotransduction, the pathway by which mechanical forces are translated to biological signals, plays important but poorly characterized roles in physiology. PIEZOs are recently identified, widely expressed, mechanically ...

    • Gait patterns associated with thyroid function: The Rotterdam Study 

      Bano, Arjola; Chaker, Layal; Darweesh, Sirwan K. L.; Korevaar, Tim I. M.; Mattace-Raso, Francesco U. S.; Dehghan, Abbas; Franco, Oscar H.; van der Geest, Jos N.; Ikram, M. Arfan; Peeters, Robin P. (Nature Publishing Group, 2016)
      Gait is an important health indicator and poor gait is strongly associated with disability and risk of falls. Thyroid dysfunction is suggested as a potential determinant of gait deterioration, but this has not been explored ...

    • Galectin‐3 Is Elevated and Associated With Adverse Outcomes in Patients With Single‐Ventricle Fontan Circulation 

      Opotowsky, Alexander R.; Baraona, Fernando; Owumi, Justin; Loukas, Brittani; Singh, Michael N.; Valente, Anne Marie; Wu, Fred; Cheng, Susan; Veldtman, Gruschen; Rimm, Eric B.; Landzberg, Michael J. (John Wiley and Sons Inc., 2016)
      Background: Galectin‐3 may play a role in cardiac and noncardiac fibrosis, and elevated circulating levels of this protein predict adverse outcomes in patients with heart failure who do not have congenital heart disease. ...

    • Gallstones and risk of coronary heart disease: prospective analysis of 270,000 men and women from 3 US cohorts and meta-analysis 

      Zheng, Yan; Xu, Min; Li, Yanping; Hruby, Adela; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Hu, Frank; Wirth, Janine; Albert, Christine; Rexrode, Kathryn; Manson, JoAnn; Qi, Lu (American Heart Association, 2016)
      Objective Gallstone disease has been related to cardiovascular risk factors; however, whether presence of gallstones predicts coronary heart disease (CHD) is not well established.Approach and Results We followed up 269142 ...