Browsing SPH Scholarly Articles by Title
Now showing items 2633-2652 of 6362
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A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation
(Public Library of Science, 2008)We conducted a multi-stage genome-wide association study of natural hair color in more than 10,000 men and women of European ancestry from the United States and Australia. An initial analysis of 528,173 single nucleotide ... -
Genome-wide association study identifies novel loci predisposing to cutaneous melanoma
(Oxford University Press, 2011)We performed a multistage genome-wide association study of melanoma. In a discovery cohort of 1804 melanoma cases and 1026 controls, we identified loci at chromosomes 15q13.1 (HERC2/OCA2 region) and 16q24.3 (MC1R) regions ... -
Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma
(Nature Publishing Group, 2016)Cutaneous squamous cell carcinoma represents the second most common cutaneous malignancy, affecting 7–11% of Caucasians in the United States. The genetic determinants of susceptibility to cutaneous squamous cell carcinoma ... -
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
(BioMed Central, 2015)Background: Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed ... -
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population
(Nature Publishing Group, 2011) -
Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma
(2013)Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. In order to better understand the genetic etiology of osteosarcoma, we performed a multi-stage genome-wide association study (GWAS) ... -
Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children
(Public Library of Science, 2009)Many candidate genes have been studied for asthma, but replication has varied. Novel candidate genes have been identified for various complex diseases using genome-wide association studies (GWASs). We conducted a GWAS in ... -
Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis
(Public Library of Science, 2012)The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide ... -
A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis
(Oxford University Press, 2013)Atopic dermatitis (AD) is the most common dermatological disease of childhood. Many children with AD have asthma and AD shares regions of genetic linkage with psoriasis, another chronic inflammatory skin disease. We present ... -
Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25
(Nature Pub. Group, 2014)The genetic contributions to breast cancer development among Latinas are not well understood. Here we carry out a genome-wide association study of breast cancer in Latinas and identify a genome-wide significant risk variant, ... -
A genome-wide association study of bronchodilator response in asthmatics
(Nature Publishing Group, 2013)Reversibility of airway obstruction in response to β2-agonists is highly variable among asthmatics, which is partially attributed to genetic factors. In a genome-wide association study of acute bronchodilator response (BDR) ... -
Genome-Wide Association Study of Circulating Estradiol, Testosterone, and Sex Hormone-Binding Globulin in Postmenopausal Women
(Public Library of Science, 2012)Genome-wide association studies (GWAS) have successfully identified common genetic variants that contribute to breast cancer risk. Discovering additional variants has become difficult, as power to detect variants of weaker ... -
Genome-Wide Association Study of Circulating Vitamin D Levels
(Oxford University Press, 2010)The primary circulating form of vitamin D, 25-hydroxy-vitamin D [25(OH)D], is associated with multiple medical outcomes, including rickets, osteoporosis, multiple sclerosis and cancer. In a genome-wide association study ... -
Genome-wide association study of colorectal cancer identifies six new susceptibility loci
(Nature Research (part of Springer Nature), 2015)Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases ... -
A genome-wide association study of early menopause and the combined impact of identified variants
(Oxford University Press, 2013)Early menopause (EM) affects up to 10% of the female population, reducing reproductive lifespan considerably. Currently, it constitutes the leading cause of infertility in the western world, affecting mainly those women ... -
Genome-wide association study of endometrial cancer in E2C2
(Springer Berlin Heidelberg, 2013)Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC ... -
Genome-wide Association Study of Glioma and Meta-Analysis
(Springer (part of Springer Nature), 2012)Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the last 20 years, remain among the most lethal tumors, underscoring the need for gaining new ... -
A genome-wide association study of Hodgkin Lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21, and 10p14 (GATA3)
(2014)To identify predisposition loci for classical Hodgkin Lymphoma (cHL) we conducted a genome-wide association study of 589 cHL cases and 5,199 controls with validation in 4 independent samples totaling 2,057 cases and 3,416 ... -
Genome-Wide Association Study of Human Immunodeficiency Virus (HIV)-1 Coreceptor Usage in Treatment-Naive Patients from An AIDS Clinical Trials Group Study
(Oxford University Press, 2014)Objectives. We conducted a genome-wide association study to explore whether common host genetic variants (>5% frequency) were associated with presence of virus able to use CXCR4 for entry. Methods. Phenotypic determination ... -
A genome-wide association study of marginal zone lymphoma shows association to the HLA region
(Nature Pub. Group, 2015)Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci ...