Browsing SPH Scholarly Articles by Title

Now showing items 2637-2656 of 6362

    • Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population 

      Hirota, Tomomitsu; Takahashi, Atsushi; Kubo, Michiaki; Tsunoda, Tatsuhiko; Tomita, Kaori; Doi, Satoru; Fujita, Kimie; Miyatake, Akihiko; Enomoto, Tadao; Miyagawa, Takehiko; Adachi, Mitsuru; Tanaka, Hiroshi; Niimi, Akio; Matsumoto, Hisako; Ito, Isao; Masuko, Hironori; Sakamoto, Tohru; Hizawa, Nobuyuki; Taniguchi, Masami; Lima, John J; Irvin, Charles G; Peters, Stephen P; Himes, Blanca; Litonjua, Augusto Ampil; Tantisira, Kelan; Weiss, Scott Tillman; Kamatani, Naoyuki; Nakamura, Yusuke; Tamari, Mayumi (Nature Publishing Group, 2011)

    • Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma 

      Savage, Sharon A.; Mirabello, Lisa; Wang, Zhaoming; Gastier-Foster, Julie M.; Gorlick, Richard; Khanna, Chand; Flanagan, Adrienne M.; Tirabosco, Roberto; Andrulis, Irene L.; Wunder, Jay S.; Gokgoz, Nalan; Patiño-Garcia, Ana; Sierrasesúmaga, Luis; Lecanda, Fernando; Kurucu, Nilgün; Ilhan, Inci Ergurhan; Sari, Neriman; Serra, Massimo; Hattinger, Claudia; Picci, Piero; Spector, Logan; Barkauskas, Donald A.; Marina, Neyssa; de Toledo, Silvia Regina Caminada; Petrilli, Antonio S.; Amary, Maria Fernanda; Halai, Dina; Thomas, David M.; Douglass, Chester; Meltzer, Paul S.; Jacobs, Kevin; Chung, Charles C.; Berndt, Sonja I.; Purdue, Mark P.; Caporaso, Neil E.; Tucker, Margaret; Rothman, Nathaniel; Landi, Maria Teresa; Silverman, Debra T.; Kraft, Peter; Hunter, David J.; Malats, Nuria; Kogevinas, Manolis; Wacholder, Sholom; Troisi, Rebecca; Helman, Lee; Fraumeni, Joseph F.; Yeager, Meredith; Hoover, Robert N.; Chanock, Stephen J. (2013)
      Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. In order to better understand the genetic etiology of osteosarcoma, we performed a multi-stage genome-wide association study (GWAS) ...

    • Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children 

      Hancock, Dana B.; Romieu, Isabelle; Sienra-Monge, Juan-Jose; Chiu, Grace Y.; Li, Huiling; del Rio-Navarro, Blanca Estela; Willis-Owens, Saffron A. G.; Eng, Celeste; Chapela, Rocio; Burchard, Esteban G.; Tang, Hua; Sullivan, Patrick F.; London, Stephanie J.; Shi, Min; Wu, Hao; Weiss, Scott Tillman; Raby, Benjamin Alexander; Gao, Hong (Public Library of Science, 2009)
      Many candidate genes have been studied for asthma, but replication has varied. Novel candidate genes have been identified for various complex diseases using genome-wide association studies (GWASs). We conducted a GWAS in ...

    • Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis 

      Hager, Jörg; Kamatani, Yoichiro; Cazier, Jean-Baptiste; Youhanna, Sonia; Ghassibe-Sabbagh, Michella; Platt, Daniel E.; Abchee, Antoine B.; Romanos, Jihane; Khazen, Georges; Othman, Raed; Badro, Danielle A.; Haber, Marc; Salloum, Angelique K.; Douaihy, Bouchra; Shasha, Nabil; Kabbani, Samer; Sbeite, Hana; Chammas, Elie; el Bayeh, Hamid; Rousseau, Francis; Zelenika, Diana; Gut, Ivo; Lathrop, Mark; Farrall, Martin; Gauguier, Dominique; Zalloua, Pierre A. (Public Library of Science, 2012)
      The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide ...

    • A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis 

      Weidinger, Stephan; Willis-Owen, Saffron A.G.; Kamatani, Yoichiro; Baurecht, Hansjörg; Morar, Nilesh; Liang, Liming; Edser, Pauline; Street, Teresa; Rodriguez, Elke; O'Regan, Grainne M.; Beattie, Paula; Fölster-Holst, Regina; Franke, Andre; Novak, Natalija; Fahy, Caoimhe M.; Winge, Mårten C.G.; Kabesch, Michael; Illig, Thomas; Heath, Simon; Söderhäll, Cilla; Melén, Erik; Pershagen, Göran; Kere, Juha; Bradley, Maria; Lieden, Agne; Nordenskjold, Magnus; Harper, John I.; Mclean, W.H. Irwin; Brown, Sara J.; Cookson, William O.C.; Lathrop, G. Mark; Irvine, Alan D.; Moffatt, Miriam F. (Oxford University Press, 2013)
      Atopic dermatitis (AD) is the most common dermatological disease of childhood. Many children with AD have asthma and AD shares regions of genetic linkage with psoriasis, another chronic inflammatory skin disease. We present ...

    • Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25 

      Fejerman, Laura; Ahmadiyeh, Nasim; Hu, Donglei; Huntsman, Scott; Beckman, Kenneth B.; Caswell, Jennifer L.; Tsung, Karen; John, Esther M.; Torres-Mejia, Gabriela; Carvajal-Carmona, Luis; Echeverry, María Magdalena; Tuazon, Anna Marie D.; Ramirez, Carolina; Bohórquez, Mabel Elena; Prieto, Rodrigo; Criollo, Ángel; Ramírez, Carolina; Estrada, Ana Patricia; Suáres, John Jairo; Mateus, Gilbert; Castro, Jorge Mario; Sánchez, Yesid; Murillo, Raúl; Lucia Serrano, Martha; Sanabria, Carolina; Olaya, Justo Germán; Bolaños, Fernando; Vélez, Alejandro; Carmona, Jenny Andrea; Rodríguez, Nancy Guerrero; Serón Sousa, Cristina; Mendez, Cesar Eduardo Alvarez; Galviz, Ana Isabel Orduz; Gignoux, Christopher R.; Eng, Celeste; Gonzalez-Burchard, Esteban; Henderson, Brian; Marchand, Loic Le; Kooperberg, Charles; Hou, Lifang; Agalliu, Ilir; Kraft, Peter; Lindström, Sara; Perez-Stable, Eliseo J.; Haiman, Christopher A.; Ziv, Elad (Nature Pub. Group, 2014)
      The genetic contributions to breast cancer development among Latinas are not well understood. Here we carry out a genome-wide association study of breast cancer in Latinas and identify a genome-wide significant risk variant, ...

    • A genome-wide association study of bronchodilator response in asthmatics 

      Duan, Q; Lasky-Su, Jessica A. Lasky; Himes, Blanca; Qiu, Weiliang; Litonjua, Augusto Ampil; Damask, Amy; Lazarus, Richard James; Klanderman, Barbara; Irvin, Charles G.; Peters, Stephen P; Hanrahan, John P; Lima, John J.; Martinez, Fernando D.; Mauger, David; Chinchilli, Vernon M.; Soto-Quiros, Manuel; Avila, Lydiana; Celedón, Juan C.; Lange, Christoph; Weiss, Scott Tillman; Tantisira, Kelan (Nature Publishing Group, 2013)
      Reversibility of airway obstruction in response to β2-agonists is highly variable among asthmatics, which is partially attributed to genetic factors. In a genome-wide association study of acute bronchodilator response (BDR) ...

    • Genome-Wide Association Study of Circulating Estradiol, Testosterone, and Sex Hormone-Binding Globulin in Postmenopausal Women 

      Prescott, Jennifer; Thompson, Deborah J.; Kraft, Peter; Chanock, Stephen J.; Audley, Tina; Brown, Judith; Leyland, Jean; Folkerd, Elizabeth; Doody, Deborah; Hankinson, Susan Elizabeth; Hunter, David J.; Jacobs, Kevin B.; Dowsett, Mitch; Cox, David G.; Easton, Douglas F.; De Vivo, Immaculata (Public Library of Science, 2012)
      Genome-wide association studies (GWAS) have successfully identified common genetic variants that contribute to breast cancer risk. Discovering additional variants has become difficult, as power to detect variants of weaker ...

    • Genome-Wide Association Study of Circulating Vitamin D Levels 

      Ahn, Jiyoung; Yu, Kai; Stolzenberg-Solomon, Rachael; McCullough, Marjorie L.; Gallicchio, Lisa; Jacobs, Eric J.; Helzlsouer, Kathy; Jacobs, Kevin B.; Li, Qizhai; Weinstein, Stephanie J.; Purdue, Mark; Virtamo, Jarmo; Horst, Ronald; Chanock, Stephen; Hayes, Richard B.; Kraft, Peter; Albanes, Demetrius; Simon, Kelly Claire; Ascherio, Alberto B.; Wheeler, William; Hunter, David J. (Oxford University Press, 2010)
      The primary circulating form of vitamin D, 25-hydroxy-vitamin D [25(OH)D], is associated with multiple medical outcomes, including rickets, osteoporosis, multiple sclerosis and cancer. In a genome-wide association study ...

    • Genome-wide association study of colorectal cancer identifies six new susceptibility loci 

      Schumacher, Fredrick; Schmit, Stephanie; Jiao, Shuo; Edlund, Christopher; Wang, Hansong; Zhang, Ben; Hsu, Li; Huang, Shu-Chen; Fischer, Christopher; Harju, John; Idos, Gregory; Lejbkowicz, Flavio; Manion, Frank; McDonnell, Kevin; McNeil, Caroline; Melas, Marilena; Rennert, Hedy; Shi, Wei; Thomas, Duncan; Van Den Berg, David J.; Hutter, Carolyn; Aragaki, Aaron; Butterbach, Katja; Caan, Bette; Carlson, Christopher; Chanock, Stephen; Curtis, Keith; Fuchs, Charles; Gala, Manish; Giovannucci, Edward; Gogarten, Stephanie; Hayes, Richard; Henderson, Brian; Hunter, David; Jackson, Rebecca; Kolonel, Laurence; Kooperberg, Charles; Sébastien Küry; LaCroix, Andrea; Laurie, Cathy; Laurie, Cecelia; Lemire, Mathieu; Levine, David; Ma, Jing; Makar, Karen; Qu, Conghui; Taverna, Darin; Ulrich, Cornelia; Wu, Kana; Kono, Suminori; West, Dee; Berndt, Sonja; Stéphane Bezieau; Brenner, Hermann; Campbell, Peter; Chan, Andrew; Chang-Claude, Jenny; Coetzee, Gerhard; Conti, David; Duggan, David; Figueiredo, Jane; Fortini, Barbara; Gallinger, Steven; Gauderman, W. James; Giles, Graham; Green, Roger; Haile, Robert; Harrison, Tabitha; Hoffmeister, Michael; Hopper, John; Hudson, Thomas; Jacobs, Eric; Iwasaki, Motoki; Jee, Sun Ha; Jenkins, Mark; Jia, Wei-Hua; Joshi, Amit; Li, Li; Lindor, Noralene; Matsuo, Keitaro; Moreno, Victor; Mukherjee, Bhramar; Newcomb, Polly; Potter, John; Raskin, Leon; Rennert, Gad; Rosse, Stephanie; Severi, Gianluca; Schoen, Robert; Seminara, Daniela; Shu, Xiao-Ou; Slattery, Martha; Tsugane, Shoichiro; White, Emily; Xiang, Yong-Bing; Zanke, Brent; Zheng, Wei; Le Marchand, Loic; Casey, Graham; Gruber, Stephen (Nature Research (part of Springer Nature), 2015)
      Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases ...

    • A genome-wide association study of early menopause and the combined impact of identified variants 

      Perry, John R. B.; Corre, Tanguy; Esko, Tõnu; Chasman, Daniel Ian; Fischer, Krista; Franceschini, Nora; He, Chunyan; Kutalik, Zoltan; Mangino, Massimo; Rose, Lynda M.; Vernon Smith, Albert; Stolk, Lisette; Sulem, Patrick; Weedon, Michael N.; Zhuang, Wei V.; Arnold, Alice; Ashworth, Alan; Bergmann, Sven; Buring, Julie Elizabeth; Burri, Andrea; Chen, Constance; Cornelis, Marilyn; Couper, David J.; Goodarzi, Mark O.; Gudnason, Vilmundur; Harris, Tamara; Hofman, Albert; Jones, Michael; Kraft, Phillip L.; Launer, Lenore; Laven, Joop S. E.; Li, Guoan; McKnight, Barbara; Masciullo, Corrado; Milani, Lili; Orr, Nicholas; Psaty, Bruce M.; Ridker, Paul M.; Rivadeneira, Fernando; Sala, Cinzia; Salumets, Andres; Schoemaker, Minouk; Traglia, Michela; Waeber, Gérard; Chanock, Stephen J.; Demerath, Ellen W.; Garcia, Melissa; Hankinson, Susan Elizabeth; Hu, Frank B.; Hunter, David J.; Lunetta, Kathryn L.; Metspalu, Andres; Montgomery, Grant W.; Murabito, Joanne M.; Newman, Anne B.; Ong, Ken K.; Spector, Tim D.; Stefansson, Kari; Swerdlow, Anthony J.; Thorsteinsdottir, Unnur; van Dam, Rob M.; Uitterlinden, André G.; Visser, Jenny A.; Vollenweider, Peter; Toniolo, Daniela; Murray, Anna (Oxford University Press, 2013)
      Early menopause (EM) affects up to 10% of the female population, reducing reproductive lifespan considerably. Currently, it constitutes the leading cause of infertility in the western world, affecting mainly those women ...

    • Genome-wide association study of endometrial cancer in E2C2 

      De Vivo, Immaculata; Prescott, Jennifer; Setiawan, Veronica Wendy; Olson, Sara H.; Wentzensen, Nicolas; Attia, John; Black, Amanda; Brinton, Louise; Chen, Chu; Chen, Constance; Cook, Linda S.; Crous-Bou, Marta; Doherty, Jennifer; Dunning, Alison M.; Easton, Douglas F.; Friedenreich, Christine M.; Garcia-Closas, Montserrat; Gaudet, Mia M.; Haiman, Christopher; Hankinson, Susan E.; Hartge, Patricia; Henderson, Brian E.; Holliday, Elizabeth; Horn-Ross, Pamela L.; Hunter, David J.; Le Marchand, Loic; Liang, Xiaolin; Lissowska, Jolanta; Long, Jirong; Lu, Lingeng; Magliocco, Anthony M.; McEvoy, Mark; O’Mara, Tracy A.; Orlow, Irene; Painter, Jodie N.; Pooler, Loreall; Rastogi, Radhai; Rebbeck, Timothy R.; Risch, Harvey; Sacerdote, Carlotta; Schumacher, Fredrick; Scott, Rodney J.; Sheng, Xin; Shu, Xiao-ou; Spurdle, Amanda B.; Thompson, Deborah; VanDen Berg, David; Weiss, Noel S.; Xia, Lucy; Xiang, Yong-Bing; Yang, Hannah P.; Yu, Herbert; Zheng, Wei; Chanock, Stephen; Kraft, Peter (Springer Berlin Heidelberg, 2013)
      Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC ...

    • Genome-wide Association Study of Glioma and Meta-Analysis 

      Rajaraman, Preetha; Melin, Beatrice; Wang, Zhaoming; McKean-Cowdin, Roberta; Michaud, Dominique; Wang, Sophia; Bondy, Melissa; Houlston, Richard; Jenkins, Robert; Wrensch, Margaret; Yeager, Meredith; Ahlbom, Anders; Albanes, Demetrius; Andersson, Ulrika; Freeman, Laura E. Beane; Buring, Julie; Butler, Mary Ann; Braganza, Melissa; Carreon, Tania; Feychting, Maria; Fleming, Sarah; Gapstur, Susan; Gaziano, J. Michael; Giles, Graham; Hallmans, Goran; Henriksson, Roger; Hoffman-Bolton, Judith; Inskip, Peter; Johansen, Christoffer; Kitahara, Cari; Lathrop, Mark; Liu, Chenwei; Le Marchand, Loic; Linet, Martha; Lonn, Stefan; Peters, Ulrike; Purdue, Mark; Rothman, Nathaniel; Ruder, Avima; Sanson, Marc; Sesso, Howard; Severi, Gianluca; Shu, Xiao-Ou; Simon, Matthias; Stampfer, Meir; Stevens, Victoria; Visvanathan, Kala; White, Emily; Wolk, Alicja; Zeleniuch-Jacquotte, Anne; Zheng, Wei; Decker, Paul; Enciso-Mora, Victor; Fridley, Brooke; Gao, Yu-Tang; Kosel, Matt; Lachance, Dan; Lau, Ching; Rice, Terri; Swerdlow, Anthony; Wiemels, Joe; Wiencke, John; Shete, Sanjay; Xiang, Yong-Bing; Xiao, Yuanyuan; Hoover, Robert; Fraumeni, Joseph Jr.; Chatterjee, Nilanjan; Hartge, Patricia; Chanock, Stephen (Springer (part of Springer Nature), 2012)
      Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the last 20 years, remain among the most lethal tumors, underscoring the need for gaining new ...

    • A genome-wide association study of Hodgkin Lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21, and 10p14 (GATA3) 

      Enciso-Mora, Victor; Broderick, Peter; Ma, Yussanne; Jarrett, Ruth F; Hjalgrim, Henrik; Hemminki, Kari; van den Berg, Anke; Olver, Bianca; Lloyd, Amy; Dobbins, Sara E; Lightfoot, Tracy; van Leeuwen, Flora E; Försti, Asta; Diepstra, Arjan; Broeks, Annegien; Vijayakrishnan, Jayaram; Shield, Lesley; Lake, Annette; Montgomery, Dorothy; Roman, Eve; Engert, Andreas; von Strandmann, Elke Pogge; Reiners, Katrin S.; Nolte, Ilja M; Smedby, Karin E; Adami, Hans-Olov; Russell, Nicola S; Glimelius, Bengt; Hamilton-Dutoit, Stephen; de Bruin, Marieke; Ryder, Lars P; Molin, Daniel; Sorensen, Karina Meden; Chang, Ellen T; Taylor, Malcolm; Cooke, Rosie; Hofstra, Robert; Westers, Helga; van Wezel, Tom; van Eijk, Ronald; Ashworth, Alan; Rostgaard, Klaus; Melbye, Mads; Swerdlow, Anthony J; Houlston, Richard S (2014)
      To identify predisposition loci for classical Hodgkin Lymphoma (cHL) we conducted a genome-wide association study of 589 cHL cases and 5,199 controls with validation in 4 independent samples totaling 2,057 cases and 3,416 ...

    • Genome-Wide Association Study of Human Immunodeficiency Virus (HIV)-1 Coreceptor Usage in Treatment-Naive Patients from An AIDS Clinical Trials Group Study 

      Henrich, Timothy J.; McLaren, Paul J.; Rao, Suhas S. P.; Lin, Nina H.; Hanhauser, Emily; Giguel, Francoise; Gulick, Roy M.; Ribaudo, Heather; de Bakker, Paul I. W.; Kuritzkes, Daniel R. (Oxford University Press, 2014)
      Objectives. We conducted a genome-wide association study to explore whether common host genetic variants (>5% frequency) were associated with presence of virus able to use CXCR4 for entry. Methods. Phenotypic determination ...

    • A genome-wide association study of marginal zone lymphoma shows association to the HLA region 

      Vijai, Joseph; Wang, Zhaoming; Berndt, Sonja I.; Skibola, Christine F.; Slager, Susan L.; de Sanjose, Silvia; Melbye, Mads; Glimelius, Bengt; Bracci, Paige M.; Conde, Lucia; Birmann, Brenda M.; Wang, Sophia S.; Brooks-Wilson, Angela R.; Lan, Qing; de Bakker, Paul I. W.; Vermeulen, Roel C. H.; Portlock, Carol; Ansell, Stephen M.; Link, Brian K.; Riby, Jacques; North, Kari E.; Gu, Jian; Hjalgrim, Henrik; Cozen, Wendy; Becker, Nikolaus; Teras, Lauren R.; Spinelli, John J.; Turner, Jenny; Zhang, Yawei; Purdue, Mark P.; Giles, Graham G.; Kelly, Rachel S.; Zeleniuch-Jacquotte, Anne; Ennas, Maria Grazia; Monnereau, Alain; Bertrand, Kimberly A.; Albanes, Demetrius; Lightfoot, Tracy; Yeager, Meredith; Chung, Charles C.; Burdett, Laurie; Hutchinson, Amy; Lawrence, Charles; Montalvan, Rebecca; Liang, Liming; Huang, Jinyan; Ma, Baoshan; Villano, Danylo J.; Maria, Ann; Corines, Marina; Thomas, Tinu; Novak, Anne J.; Dogan, Ahmet; Liebow, Mark; Thompson, Carrie A.; Witzig, Thomas E.; Habermann, Thomas M.; Weiner, George J.; Smith, Martyn T.; Holly, Elizabeth A.; Jackson, Rebecca D.; Tinker, Lesley F.; Ye, Yuanqing; Adami, Hans-Olov; Smedby, Karin E.; De Roos, Anneclaire J.; Hartge, Patricia; Morton, Lindsay M.; Severson, Richard K.; Benavente, Yolanda; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; McKay, James; Staines, Anthony; Diver, W. Ryan; Vajdic, Claire M.; Armstrong, Bruce K.; Kricker, Anne; Zheng, Tongzhang; Holford, Theodore R.; Severi, Gianluca; Vineis, Paolo; Ferri, Giovanni M.; Ricco, Rosalia; Miligi, Lucia; Clavel, Jacqueline; Giovannucci, Edward; Kraft, Peter; Virtamo, Jarmo; Smith, Alex; Kane, Eleanor; Roman, Eve; Chiu, Brian C. H.; Fraumeni, Joseph F.; Wu, Xifeng; Cerhan, James R.; Offit, Kenneth; Chanock, Stephen J.; Rothman, Nathaniel; Nieters, Alexandra (Nature Pub. Group, 2015)
      Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci ...

    • A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study 

      Granada, Mark; Wilk, Jemma; Tuzova, Marina; Strachan, David P.; Weidinger, Stephan; Albrecht, Eva; Gieger, Christian; Heinrich, Joachim; Himes, Blanca; Hunninghake, Gary Matthew; Celedón, Juan C.; Weiss, Scott Tillman; Cruikshank, William W.; Farrer, Lindsay A.; Center, David M.; O'Connor, George T. (Elsevier BV, 2012)
      Background— Atopy and plasma IgE concentration are genetically complex traits, and the specific genetic risk factors that lead to IgE dysregulation and clinical atopy are an area of active investigation. Objective— To ...

    • Genome-wide Association Study of Prostate Cancer Mortality 

      Penney, Kathryn L.; Pyne, Saumyadipta; Schumacher, Fredrick R.; Sinnott, Jennifer A.; Mucci, Lorelei A.; Kraft, Peter; Ma, Jing; Oh, William K.; Kurth, Tobias; Kantoff, Philip W.; Giovannucci, Edward L.; Stampfer, Meir; Hunter, David J.; Freedman, Matthew L. (American Association for Cancer Research, 2010)
      Background: A pressing clinical issue in prostate cancer is to distinguish which men will have an indolent or aggressive course of disease. Clinical variables such as Gleason grade and stage are useful predictors of lethal ...

    • Genome-wide association study of prostate cancer-specific survival 

      Szulkin, Robert; Karlsson, Robert; Whitington, Thomas; Aly, Markus; Gronberg, Henrik; Eeles, Rosalind; Easton, Douglas; Kote-Jarai, Zsofia; Olama, Ali Amin Al; Benlloch, Sara; Muir, Kenneth; Giles, Graham; Southey, Melissa; FitzGerald, Liesel; Henderson, Brian; Schumacher, Fredrick; Haiman, Christopher; Sipeky, Csilla; Tammela, Teuvo L. J.; Nordestgaard, Børge G.; Key, Timothy; Travis, Ruth; Neal, David; Donovan, Jenny; Hamdy, Freddie; Pharoah, Paul D. P.; Pashayan, Nora; Khaw, Kay-Tee; Stanford, Janet; Thibodeau, Stephen; McDonnell, Shannon; Schaid, Daniel; Maier, Christiane; Vogel, Walther; Luedeke, Manuel; Herkommer, Kathleen; Kibel, Adam; Cybulski, Cezary; Lubiński, Jan; Kluźniak, Wojciech; Cannon-Albright, Lisa; Brenner, Hermann; Herrmann, Volker; Holleczek, Bernd; Park, Jong; Sellers, Thomas; Lim, Hui-Yi; Slavov, Chavdar; Kaneva, Radka; Mitev, Vanio; Spurdle, Amanda; Teixeira, Manuel; Paulo, Paula; Maia, Sofia; Pandha, Hardev; Michael, Agnieszka; Kierzek, Andrzej; Batra, Jyotsna; Clements, Judith; Albanes, Demetrius; Andriole, Gerald; Berndt, Sonja; Chanock, Stephen; Gapstur, Susan; Giovannucci, Edward; Hunter, David; Kraft, Peter; Le Marchand, Loic; Ma, Jing; Mondul, Alison; Penney, Kathryn; Stampfer, Meir; Stevens, Victoria; Weinstein, Stephanie; Trichopoulou, Antonia; Bueno-de-Mesquita, Bas; Tjonneland, Anne; Cox, David; Maehle, Lovise; Schleutker, Johanna; Lindström, Sara; Wiklund, Fredrik (American Association for Cancer Research, 2015)
      Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: ...

    • A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study 

      Walter, Robert E.; Nagle, Michael W.; Brandler, Brian J.; Borecki, Ingrid B.; O'Connor, George T.; McCarthy, Mark I.; Wilk, Jemma B; Chen, Ting-Hsu; Gottlieb, Daniel J; Myers, Richard Hepworth; Silverman, Edwin Kepner; Weiss, Scott Tillman (Public Library of Science, 2009)
      The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a measure used to diagnose airflow obstruction and is highly heritable. We performed a genome-wide association study in 7,691 ...