Now showing items 275-294 of 6362

    • Alcohol intake and ovarian cancer risk: a pooled analysis of 10 cohort studies 

      Genkinger, J. M.; Hunter, D. J.; Spiegelman, D.; Anderson, K. E.; Buring, J. E.; Freudenheim, J. L.; Goldbohm, R. A.; Harnack, L.; Hankinson, S. E.; Larsson, S. C.; Leitzmann, M.; McCullough, M. L.; Marshall, J.; Miller, A. B.; Rodriguez, C.; Rohan, T. E.; Schatzkin, A.; Schouten, L. J.; Wolk, A.; Zhang, S. M.; Smith-Warner, S. A (Springer Nature, 2006)
      Alcohol has been hypothesized to promote ovarian carcinogenesis by its potential to increase circulating levels of estrogen and other hormones; through its oxidation byproduct, acetaldehyde, which may act as a cocarcinogen; ...
    • Alcohol Intake and Pancreatic Cancer Risk: A Pooled Analysis of Fourteen Cohort Studies 

      Genkinger, Jeanine M.; Spiegelman, Donna; Anderson, Kristin E.; Bergkvist, Leif; Bernstein, Leslie; Brandt, Piet den; English, Dallas R.; Freudenheim, Jo L.; Fuchs, Charles S.; Giles, Graham G.; Giovannucci, Edward; Hankinson, Susan E.; Horn-Ross, Pamela L.; Leitzmann, Michael; Männistö, Satu; Marshall, James R.; McCullough, Marjorie L.; Miller, Anthony B.; Reding, Douglas J.; Robien, Kim; Rohan, Thomas E.; Schatzkin, Arthur; Stevens, Victoria L.; Stolzenberg-Solomon, Rachael; Verhage, Bas A. J.; Wolk, Alicja; Ziegler, Regina; Smith-Warner, Stephanie A. (American Association for Cancer Research, 2009)
      Background: Few risk factors have been implicated in pancreatic cancer etiology. Alcohol has been theorized to promote carcinogenesis. However, epidemiologic studies have reported inconsistent results relating alcohol ...
    • Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan) 

      Michaud, Dominique S.; Vrieling, Alina; Jiao, Li; Mendelsohn, Julie B.; Steplowski, Emily; Lynch, Shannon M.; Wactawski-Wende, Jean; Arslan, Alan A.; Bueno-de-Mesquita, H. Bas; Fuchs, Charles S.; Gross, Myron; Helzlsouer, Kathy; Jacobs, Eric J.; LaCroix, Andrea; Petersen, Gloria; Zheng, Wei; Allen, Naomi; Ammundadottir, Laufey; Bergmann, Manuela M.; Boffetta, Paolo; Buring, Julie E.; Canzian, Federico; Chanock, Stephen J.; Clavel-Chapelon, Françoise; Clipp, Sandra; Freiberg, Matthew S.; Gaziano, J. Michael; Giovannucci, Edward L.; Hankinson, Susan; Hartge, Patricia; Hoover, Robert N.; Hubbell, F. Allan; Hunter, David J.; Hutchinson, Amy; Jacobs, Kevin; Kooperberg, Charles; Kraft, Peter; Manjer, Jonas; Navarro, Carmen; Peeters, Petra M.; Shu, Xiao-Ou; Stevens, Victoria; Thomas, Gilles; Tjønneland, Anne; Tobias, Geoffrey S.; Trichopoulos, Dimitrios; Tumino, Rosario; Vineis, Paolo; Virtamo, Jarmo; Wallace, Robert; Wolpin, Brian M.; Yu, Kai; Zeleniuch-Jacquotte, Anne; Stolzenberg-Solomon, Rachael Z. (Springer (part of Springer Nature), 2010)
      The literature has consistently reported no association between low to moderate alcohol consumption and pancreatic cancer; however, a few studies have shown that high levels of intake may increase risk. Most single studies ...
    • Alcohol Intake and Renal Cell Cancer in a Pooled Analysis of 12 Prospective Studies 

      Lee, J. E.; Hunter, D. J.; Spiegelman, D.; Adami, H.-O.; Albanes, D.; Bernstein, L.; van den Brandt, P. A.; Buring, J. E.; Cho, E.; Folsom, A. R.; Freudenheim, J. L.; Giovannucci, E.; Graham, S.; Horn-Ross, P. L.; Leitzmann, M. F.; McCullough, M. L.; Miller, A. B.; Parker, A. S.; Rodriguez, C.; Rohan, T. E.; Schatzkin, A.; Schouten, L. J.; Virtanen, M.; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Wolk, A.; Zhang, S. M.; Smith-Warner, S. A. (Oxford University Press, 2007)
      Background: The association between alcohol intake and risk of renal cell cancer has been inconsistent in case-control studies. An inverse association between alcohol intake and risk of renal cell cancer has been suggested ...
    • Alcohol Intake and Risk of Coronary Heart Disease in Younger, Middle-aged and Older Adults 

      Hvidtfeldt, Ulla A.; Tolstrup, Janne S.; Jakobsen, Marianne U.; Heitmann, Berit L.; Grønbæk, Morten; O’Reilly, Eilis; Bälter, Katarina; Goldbourt, Uri; Hallmans, Göran; Knekt, Paul; Liu, Simin; Pereira, Mark; Pietinen, Pirjo; Spiegelman, Donna; Stevens, June; Virtamo, Jarmo; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Ascherio, Alberto (American Heart Association, 2010)
      Background-Light to moderate alcohol consumption is associated with a reduced risk of coronary heart disease. This protective effect of alcohol, however, may be confined to middle-aged or older individuals. Coronary heart ...
    • Alcohol Intake Between Menarche and First Pregnancy: A Prospective Study of Breast Cancer Risk 

      Liu, Ying; Colditz, Graham A.; Rosner, Bernard; Berkey, Catherine S.; Collins, Laura C.; Schnitt, Stuart J.; Connolly, James L.; Chen, Wendy Y.; Willett, Walter C.; Tamimi, Rulla M. (Oxford University Press, 2013)
      Background: Adult alcohol consumption during the previous year is related to breast cancer risk. Breast tissue is particularly susceptible to carcinogens between menarche and first full-term pregnancy. No study has ...
    • Alcohol intake, drinking patterns, and risk of nonfatal acute myocardial infarction in Costa Rica 

      Kabagambe, Edmond K.; Baylin, Ana; Ruiz-Narvaez, Edward; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Campos, Hannia (Oxford University Press, 2005)
      Background: Moderate alcohol consumption is associated with a lower risk of myocardial infarction (MI). Whether alcohol is truly protective or whether the amount, type, or pattern of intake is the most important is still ...
    • Alcohol Policies and Alcoholic Cirrhosis Mortality in the United States 

      Hadland, Scott E.; Xuan, Ziming; Blanchette, Jason G.; Heeren, Timothy C.; Swahn, Monica H.; Naimi, Timothy S. (Centers for Disease Control and Prevention, 2015)
      Introduction: Stronger alcohol policies predict decreased alcohol consumption and binge drinking in the United States. We examined the relationship between the strength of states’ alcohol policies and alcoholic cirrhosis ...
    • Alcohol Policy Enforcement and Changes in Student Drinking Rates in a Statewide Public College System: a Follow-up Study 

      Harris, Sion Kim; Sherritt, Lon; Van Hook, Shari; Wechsler, Henry; Knight, John R. (BioMed Central, 2010)
      Background: Heavy alcohol use among U.S. college students is a major contributor to young adult morbidity and mortality. The aim of this study was to examine whether college alcohol policy enforcement levels predict changes ...
    • Alcohol use and abuse in random samples of physicians and medical students 

      McAuliffe, William Edward; Rohman, Mary; Breer, Paul; Wyshak, Grace; Santangelo, Susan L.; Magnuson, Elizabeth (American Public Health Association, 1991)
      BACKGROUND: This study sought to resolve conflicting views about whether physicians are especially prone to alcohol abuse. METHODS: Using an anonymous, mailed questionnaire on substance use, we surveyed 500 physicians, ...
    • Alcohol, Hospital Discharge, and Socioeconomic Risk Factors for Default from Multidrug Resistant Tuberculosis Treatment in Rural South Africa: A Retrospective Cohort Study 

      Kendall, Emily A.; Theron, Danie; Franke, Molly F.; van Helden, Paul; Victor, Thomas C.; Murray, Megan B.; Warren, Robin M.; Jacobson, Karen R. (Public Library of Science, 2013)
      Background: Default from multidrug-resistant tuberculosis (MDR-TB) treatment remains a major barrier to cure and epidemic control. We sought to identify patient risk factors for default from MDR-TB treatment and high-risk ...
    • Alert Threshold Algorithms and Malaria Epidemic Detection 

      Teklehaimanot, Hailay Desta; Teklehaimanot, Awash; Schwartz, Joel David; Lipsitch, Marc (Centers for Disease Control and Prevention, 2004)
      We describe a method for comparing the ability of different alert threshold algorithms to detect malaria epidemics and use it with a dataset consisting of weekly malaria cases collected from health facilities in 10 districts ...
    • Alkylresorcinol Metabolite Concentrations in Spot Urine Samples Correlated with Whole Grain and Cereal Fiber Intake but Showed Low to Modest Reproducibility over One to Three Years in U.S. Women 

      Landberg, Rikard; Townsend, Mary K.; Neelakantan, Nithya; Sun, Qi; Sampson, Laura; Spiegelman, Donna; Dam, Rob van (Oxford University Press, 2012)
      Two alkylresorcinol (AR) metabolites, 3, 5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), in urine have been suggested as biomarkers of whole grain (WG) and cereal fiber intake but the ...
    • Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis 

      LaFramboise, Thomas; Weir, Barbara Ann; Zhao, Xiaojun; Beroukhim, Rameen; Li, Cheng; Harrington, David Paul; Sellers, William R; Meyerson, Matthew Langer (Public Library of Science, 2005)
      Amplification, deletion, and loss of heterozygosity of genomic DNA are hallmarks of cancer. In recent years a variety of studies have emerged measuring total chromosomal copy number at increasingly high resolution. Similarly, ...
    • Allele-Specific Methylation Occurs at Genetic Variants Associated with Complex Disease 

      Hutchinson, John N.; Raj, Towfique; Fagerness, Jes; Stahl, Eli; Viloria, Fernando T.; Gimelbrant, Alexander; Seddon, Johanna; Daly, Mark; Chess, Andrew; Plenge, Robert (Public Library of Science, 2014)
      We hypothesize that the phenomenon of allele-specific methylation (ASM) may underlie the phenotypic effects of multiple variants identified by Genome-Wide Association studies (GWAS). We evaluate ASM in a human population ...
    • Allergy and Sensitization during Childhood Associated with Prenatal and Lactational Exposure to Marine Pollutants 

      Grandjean, Philippe; Poulsen, Lars K.; Heilmann, Carsten; Steuerwald, Ulrike; Weihe, Pál (National Institute of Environmental Health Sciences, 2010)
      Background: Breast-feeding may affect the risk of developing allergy during childhood and may also cause exposure to immunotoxicants, such as polychlorinated biphenyls (PCBs), which are of concern as marine pollutants in ...
    • The alpha angle as a predictor of contralateral slipped capital femoral epiphysis 

      Boyle, Matthew J.; Lirola, Jose F.; Hogue, Grant D.; Yen, Yi-Meng; Millis, Michael B.; Kim, Young-Jo (Springer Berlin Heidelberg, 2016)
      Purpose Contralateral hip involvement in slipped capital femoral epiphysis (SCFE) is common. Femoral head−neck asphericity, as measured by an elevated alpha angle, has not previously been assessed with respect to SCFE risk. ...
    • Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model 

      Obaldía III, Nicanor; Dow, Geoffrey S.; Gerena, Lucia; Kyle, Dennis; Otero, William; Mantel, Pierre-Yves; Baro, Nicholas; Daniels, Rachel; Mukherjee, Angana; Childs, Lauren M.; Buckee, Caroline; Duraisingh, Manoj T.; Volkman, Sarah K.; Wirth, Dyann F.; Marti, Matthias (Nature Publishing Group, 2016)
      Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to artemisinin-based combination therapies. However, artemisinin resistant parasites have ...
    • Altered Host Immunity, Human T Lymphotropic Virus Type I Replication, and Risk of Adult T-Cell Leukemia/Lymphoma: A Prospective Analysis from the ATL Cohort Consortium 

      Okayama, Akihiko; Kim, Norma; Arisawa, Kokichi; Hanchard, Barrie; Inoue, Manami; Sawada, Takashi; Tsugane, Shoichiro; Li, Hongchuan; Hisada, Michie; Birmann, Brenda Melanie; Mueller, Nancy Elsa; Martínez-Maza, Otoniel; Breen, Elizabeth C.; Carneiro-Proietti, Anna B. F.; Falk, Kerstin I.; Murphy, Edward L.; Pfeiffer, Ruth M.; Stuver, Sherri O.; Suppan, Catherine A. (BioMed Central, 2011)
      Background: Adult T-cell leukemia/lymphoma (ATL) is a rare and often fatal outcome of infection with human T-lymphotropic virus type I (HTLV-I). Altered host immunity in HTLV-I carriers has been postulated as a risk factor ...
    • Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma 

      Overby, Darryl R.; Zhou, Enhua; Vargas-Pinto, Rocio; Pedrigi, Ryan M.; Fuchshofer, Rudolf; Braakman, Sietse T.; Gupta, Ritika; Perkumas, Kristin M.; Sherwood, Joseph M.; Vahabikashi, Amir; Dang, Quynh Nhu; Kim, Jae Hun; Ethier, C. Ross; Stamer, W. Daniel; Fredberg, Jeffrey J.; Johnson, Mark (Proceedings of the National Academy of Sciences, 2014)
      Increased flow resistance is responsible for the elevated intraocular pressure characteristic of glaucoma, but the cause of this resistance increase is not known. We tested the hypothesis that altered biomechanical behavior ...