Browsing SPH Scholarly Articles by Title

Now showing items 286-305 of 6362

    • Alert Threshold Algorithms and Malaria Epidemic Detection 

      Teklehaimanot, Hailay Desta; Teklehaimanot, Awash; Schwartz, Joel David; Lipsitch, Marc (Centers for Disease Control and Prevention, 2004)
      We describe a method for comparing the ability of different alert threshold algorithms to detect malaria epidemics and use it with a dataset consisting of weekly malaria cases collected from health facilities in 10 districts ...

    • Alkylresorcinol Metabolite Concentrations in Spot Urine Samples Correlated with Whole Grain and Cereal Fiber Intake but Showed Low to Modest Reproducibility over One to Three Years in U.S. Women 

      Landberg, Rikard; Townsend, Mary K.; Neelakantan, Nithya; Sun, Qi; Sampson, Laura; Spiegelman, Donna; Dam, Rob van (Oxford University Press, 2012)
      Two alkylresorcinol (AR) metabolites, 3, 5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), in urine have been suggested as biomarkers of whole grain (WG) and cereal fiber intake but the ...

    • Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis 

      LaFramboise, Thomas; Weir, Barbara Ann; Zhao, Xiaojun; Beroukhim, Rameen; Li, Cheng; Harrington, David Paul; Sellers, William R; Meyerson, Matthew Langer (Public Library of Science, 2005)
      Amplification, deletion, and loss of heterozygosity of genomic DNA are hallmarks of cancer. In recent years a variety of studies have emerged measuring total chromosomal copy number at increasingly high resolution. Similarly, ...

    • Allele-Specific Methylation Occurs at Genetic Variants Associated with Complex Disease 

      Hutchinson, John N.; Raj, Towfique; Fagerness, Jes; Stahl, Eli; Viloria, Fernando T.; Gimelbrant, Alexander; Seddon, Johanna; Daly, Mark; Chess, Andrew; Plenge, Robert (Public Library of Science, 2014)
      We hypothesize that the phenomenon of allele-specific methylation (ASM) may underlie the phenotypic effects of multiple variants identified by Genome-Wide Association studies (GWAS). We evaluate ASM in a human population ...

    • Allergy and Sensitization during Childhood Associated with Prenatal and Lactational Exposure to Marine Pollutants 

      Grandjean, Philippe; Poulsen, Lars K.; Heilmann, Carsten; Steuerwald, Ulrike; Weihe, Pál (National Institute of Environmental Health Sciences, 2010)
      Background: Breast-feeding may affect the risk of developing allergy during childhood and may also cause exposure to immunotoxicants, such as polychlorinated biphenyls (PCBs), which are of concern as marine pollutants in ...

    • The alpha angle as a predictor of contralateral slipped capital femoral epiphysis 

      Boyle, Matthew J.; Lirola, Jose F.; Hogue, Grant D.; Yen, Yi-Meng; Millis, Michael B.; Kim, Young-Jo (Springer Berlin Heidelberg, 2016)
      Purpose Contralateral hip involvement in slipped capital femoral epiphysis (SCFE) is common. Femoral head−neck asphericity, as measured by an elevated alpha angle, has not previously been assessed with respect to SCFE risk. ...

    • Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model 

      Obaldía III, Nicanor; Dow, Geoffrey S.; Gerena, Lucia; Kyle, Dennis; Otero, William; Mantel, Pierre-Yves; Baro, Nicholas; Daniels, Rachel; Mukherjee, Angana; Childs, Lauren M.; Buckee, Caroline; Duraisingh, Manoj T.; Volkman, Sarah K.; Wirth, Dyann F.; Marti, Matthias (Nature Publishing Group, 2016)
      Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to artemisinin-based combination therapies. However, artemisinin resistant parasites have ...

    • Altered Host Immunity, Human T Lymphotropic Virus Type I Replication, and Risk of Adult T-Cell Leukemia/Lymphoma: A Prospective Analysis from the ATL Cohort Consortium 

      Okayama, Akihiko; Kim, Norma; Arisawa, Kokichi; Hanchard, Barrie; Inoue, Manami; Sawada, Takashi; Tsugane, Shoichiro; Li, Hongchuan; Hisada, Michie; Birmann, Brenda Melanie; Mueller, Nancy Elsa; Martínez-Maza, Otoniel; Breen, Elizabeth C.; Carneiro-Proietti, Anna B. F.; Falk, Kerstin I.; Murphy, Edward L.; Pfeiffer, Ruth M.; Stuver, Sherri O.; Suppan, Catherine A. (BioMed Central, 2011)
      Background: Adult T-cell leukemia/lymphoma (ATL) is a rare and often fatal outcome of infection with human T-lymphotropic virus type I (HTLV-I). Altered host immunity in HTLV-I carriers has been postulated as a risk factor ...

    • Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma 

      Overby, Darryl R.; Zhou, Enhua; Vargas-Pinto, Rocio; Pedrigi, Ryan M.; Fuchshofer, Rudolf; Braakman, Sietse T.; Gupta, Ritika; Perkumas, Kristin M.; Sherwood, Joseph M.; Vahabikashi, Amir; Dang, Quynh Nhu; Kim, Jae Hun; Ethier, C. Ross; Stamer, W. Daniel; Fredberg, Jeffrey J.; Johnson, Mark (Proceedings of the National Academy of Sciences, 2014)
      Increased flow resistance is responsible for the elevated intraocular pressure characteristic of glaucoma, but the cause of this resistance increase is not known. We tested the hypothesis that altered biomechanical behavior ...

    • Altered Prion Protein Expression Pattern in CSF as a Biomarker for Creutzfeldt-Jakob Disease 

      Torres, Mauricio; Cartier, Luis; Matamala, José Manuel; Hernández, Nancy; Woehlbier, Ute; Hetz, Claudio (Public Library of Science, 2012)
      Creutzfeldt-Jakob disease (CJD) is the most frequent human Prion-related disorder (PrD). The detection of 14-3-3 protein in the cerebrospinal fluid (CSF) is used as a molecular diagnostic criterion for patients clinically ...

    • Alternate Healthy Eating Index 2010 and risk of chronic obstructive pulmonary disease among US women and men: prospective study 

      Varraso, Raphaëlle; Chiuve, Stephanie E; Fung, Teresa T; Barr, R Graham; Hu, Frank B; Willett, Walter C; Camargo, Carlos A (BMJ Publishing Group Ltd., 2015)
      Objective: To investigate the association between the Alternate Healthy Eating Index 2010 (AHEI-2010)—a measure of diet quality—and the risk of chronic obstructive pulmonary disease (COPD). Design: Prospective cohort study. ...

    • Alternative Calculations of Individual Patient Time in Therapeutic Range While Taking Warfarin: Results From the ROCKET AF Trial 

      Singer, Daniel E.; Hellkamp, Anne S.; Yuan, Zhong; Lokhnygina, Yuliya; Patel, Manesh R.; Piccini, Jonathan P.; Hankey, Graeme J.; Breithardt, Günter; Halperin, Jonathan L.; Becker, Richard C.; Hacke, Werner; Nessel, Christopher C.; Mahaffey, Kenneth W.; Fox, Keith A. A.; Califf, Robert M. (Blackwell Publishing Ltd, 2015)
      Background: In the ROCKET AF (Rivaroxaban–Once‐daily, oral, direct Factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) trial, marked regional differences ...

    • Alternative Dietary Indices Both Strongly Predict Risk of Chronic Disease 

      Chiuve, Stephanie E.; Fung, Teresa T.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Hu, Frank B.; McCullough, Marjorie L.; Wang, Molin; Stampfer, Meir; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600 (Oxford University Press, 2012)
      The Healthy Eating Index-2005 (HEI-2005) measures adherence to the 2005 Dietary Guidelines for Americans, but the association between the HEI-2005 and risk of chronic disease is not known. The Alternative Healthy Eating ...

    • An alternative hypothesis testing strategy for secondary phenotype data in case-control genetic association studies 

      Lutz, Sharon M.; Hokanson, John E.; Lange, Christoph (Frontiers Media S.A., 2014)
      Motivated by the challenges associated with accounting for the ascertainment when analyzing secondary phenotypes that are correlated with case-control status, Lin and Zeng have proposed a method that properly reflects the ...

    • Alternative Strategies to Reduce Maternal Mortality in India: A Cost-Effectiveness Analysis 

      Goldie, Sue J.; Sweet, Steven Goldie; Carvalho, Natalie Ida; Natchu, Uma Chandra Mouli; Hu, Delphine (Public Library of Science, 2010)
      Background: Approximately one-quarter of all pregnancy- and delivery-related maternal deaths worldwide occur in India. Taking into account the costs, feasibility, and operational complexity of alternative interventions, ...

    • Alternatives to PFASs: Perspectives on the Science 

      Birnbaum, Linda S.; Grandjean, Philippe (Environmental Health Perspectives, 2015)

    • Alu and LINE-1 methylation and lung function in the normative ageing study 

      Lange, Nancy E; Sordillo, Joanne; Tarantini, Letizia; Bollati, Valentina; Sparrow, David; Vokonas, Pantel; Zanobetti, Antonella; Schwartz, Joel David; Baccarelli, Andrea; Litonjua, Augusto Ampil; Demeo, Dawn Lisa (BMJ Publishing Group, 2012)
      Objectives: To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear elements (LINE-1) and lung function. Design: Cohort study. Setting: Outpatient Veterans Administration ...

    • Alveolar Macrophage Interaction With Air Pollution Particulates 

      Goldsmith, C A; Frevert, C; Imrich, A; Sioutas, C; Kobzik, Lester (National Institute of Environmental Health Sciences, 1997)
      We applied flow cytometric analysis to characterize the in vitro response of alveolar macrophages (AM) to air pollution particulates. Normal hamster AM were incubated with varying concentrations of residual oil fly ash ...

    • Alzheimer’s loci: epigenetic associations and interaction with genetic factors 

      Chibnik, Lori B; Yu, Lei; Eaton, Matthew L; Srivastava, Gyan; Schneider, Julie A; Kellis, Manolis; Bennett, David A; De Jager, Philip L (John Wiley & Sons, Ltd, 2015)
      Objective: We explore the role of DNA methylation in Alzheimer’s disease (AD). To elucidate where DNA methylation falls along the causal pathway linking risk factors to disease, we examine causal models to assess its role ...

    • Ambient Air Pollution and Depressive Symptoms in Older Adults: Results from the MOBILIZE Boston Study 

      Wang, Yi; Eliot, Melissa N.; Koutrakis, Petros; Gryparis, Alexandros; Schwartz, Joel D.; Coull, Brent A.; Mittleman, Murray A.; Milberg, William P.; Lipsitz, Lewis A.; Wellenius, Gregory A. (NLM-Export, 2014)
      Background: Exposure to ambient air pollution, particularly from traffic, has been associated with adverse cognitive outcomes, but the association with depressive symptoms remains unclear. Objectives: We investigated the ...