Browsing SPH Scholarly Articles by Title
Now showing items 2886-2905 of 6362
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Hierarchical Bayesian analysis of somatic mutation data in cancer
(Institute of Mathematical Statistics, 2013)Identifying genes underlying cancer development is critical to cancer biology and has important implications across prevention, diagnosis and treatment. Cancer sequencing studies aim at discovering genes with high frequencies ... -
HIF1A Overexpression Is Associated with Poor Prognosis in a Cohort of 731 Colorectal Cancers
(Elsevier, 2010)Tissue hypoxia commonly occurs in tumors. Hypoxia-inducible factor (HIF)-1 and HIF-2, which are essential mediators of cellular response to hypoxia, regulate gene expression for tumor angiogenesis, glucose metabolism, and ... -
High Accuracy of Common HIV-Related Oral Disease Diagnoses by Non-Oral Health Specialists in the AIDS Clinical Trial Group
(Public Library of Science, 2015)Objective: Many studies include oral HIV-related endpoints that may be diagnosed by non-oral-health specialists (non-OHS) like nurses or physicians. Our objective was to assess the accuracy of clinical diagnoses of HIV-related ... -
High Avidity CD8+ T Cells Efficiently Eliminate Motile HIV-Infected Targets and Execute a Locally Focused Program of Anti-Viral Function
(Public Library of Science, 2014)The dissemination of HIV from an initial site of infection is facilitated by motile HIV-infected CD4+ T-cells. However, the impact of infected target cell migration on antigen recognition by HIV-specific CD8+ T-cells is ... -
High breast milk levels of polychlorinated biphenyls (PCBs) among four women living adjacent to a PCB-contaminated waste site
(National Institute of Environmental Health Sciences, 1998)As a consequence of contamination by effluents from local electronics manufacturing facilities, the New Bedford Harbor and estuary in southeastern Massachusetts is among the sites in the United States that are considered ... -
High fat diet enhances stemness and tumorigenicity of intestinal progenitors
(2016)Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we find that high fat diet (HFD)-induced obesity augments the numbers and function of Lgr5+ intestinal stem-cells (ISCs) ... -
High Frequency of Transmitted HIV-1 Gag HLA Class I-Driven Immune Escape Variants but Minimal Immune Selection over the First Year of Clade C Infection
(Public Library of Science, 2015)In chronic HIV infection, CD8+ T cell responses to Gag are associated with lower viral loads, but longitudinal studies of HLA-restricted CD8+ T cell-driven selection pressure in Gag from the time of acute infection are ... -
High Hemoglobin A1c and Diabetes Predict Memory Decline in the Health and Retirement Study
(, 2017)Background:Type 2 diabetes (T2D) is an established risk factor for dementia, but evidence for T2D and memory decline is less consistent. Understanding how T2D and blood glucose relate to memory decline is crucial to ... -
High Hopes, Grim Reality: Reintegration and the Education of Former Child Soldiers in Sierra Leone
(University of Chicago Press, 2008)Civil war broke out in Sierra Leone in 1991 and lasted more than a decade. During the conflict, both the national army and the Revolutionary United Front (RUF), a rebel group responsible for some of the worst atrocities ... -
High latitude and marine diet: vitamin D status in elderly Faroese
(Cambridge University Press (CUP), 2010)Human subjects obtain their vitamin D from the diet, especially from marine food, and from endogenous synthesis following cutaneous sun exposure. The risk of an insufficient vitamin D synthesis is increased in northern ... -
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer
(National Academy of Sciences, 2011)Heat-shock factor 1 (HSF1) is the master transcriptional regulator of the cellular response to heat and a wide variety of other stressors. We previously reported that HSF1 promotes the survival and proliferation of malignant ... -
High Phobic Anxiety Is Related to Lower Leukocyte Telomere Length in Women
(Public Library of Science, 2012)Background: Chronic psychological distress has been linked to shorter telomeres, an indication of accelerated aging. Yet, little is known about relations of anxiety to telomeres. We examined whether a typically chronic ... -
High Prevalence of Hypertension and Placental Insufficiency, but No In Utero HIV Transmission, among Women on HAART with Stillbirths in Botswana
(Public Library of Science, 2012)Background: Increased stillbirth rates occur among HIV-infected women, but no studies have evaluated the pathological basis for this increase, or whether highly active antiretroviral therapy (HAART) influences the etiology ... -
High prevalence of Plasmodium falciparum gametocyte infections in school-age children using molecular detection: patterns and predictors of risk from a cross-sectional study in southern Malawi
(BioMed Central, 2016)Background: In endemic areas, many people experience asymptomatic Plasmodium infections, particularly older children and adults, but their transmission contribution is unknown. Though not the exclusive determinant of ... -
High rates of unplanned interruptions from HIV care early after antiretroviral therapy initiation in Nigeria
(BioMed Central, 2015)Background: Unplanned care interruption (UCI) challenges effective HIV treatment. We determined the frequency and risk factors for UCI in Nigeria. Methods: We conducted a retrospective-cohort study of adults initiating ... -
High Resolution Characterization of Engineered Nanomaterial Dispersions in Complex Media Using Tunable Resistive Pulse Sensing Technology
(American Chemical Society, 2014)In vitro toxicity assessment of engineered nanomaterials (ENM), the most common testing platform for ENM, requires prior ENM dispersion, stabilization, and characterization in cell culture media. Dispersion inefficiencies ... -
High risk for obstructive sleep apnea and other sleep disorders among overweight and obese pregnant women
(BioMed Central, 2015)Background: Obstructive sleep apnea (OSA), a common and serious disorder in which breathing repeatedly stops during sleep, is associated with excess weight and obesity. Little is known about the co-occurrence of OSA among ... -
High school dietary dairy intake and teenage acne
(Elsevier, 2005)Background: Previous studies suggest possible associations between Western diet and acne. We examined data from the Nurses Health Study II to retrospectively evaluate whether intakes of dairy foods during high school were ... -
High-dimensional genomic data bias correction and data integration using MANCIE
(Nature Publishing Group, 2016)High-dimensional genomic data analysis is challenging due to noises and biases in high-throughput experiments. We present a computational method matrix analysis and normalization by concordant information enhancement ... -
High-molecular-weight hyaluronan – a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats
(BioMed Central, 2008)Introduction: Mechanical ventilation with even moderate-sized tidal volumes synergistically increases lung injury in sepsis and has been associated with proinflammatory low-molecular-weight hyaluronan production. ...