Browsing SPH Scholarly Articles by Title
Now showing items 2910-2929 of 6362
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High-specificity bioinformatics framework for epigenomic profiling of discordant twins reveals specific and shared markers for ACPA and ACPA-positive rheumatoid arthritis
(BioMed Central, 2016)Background: Twin studies are powerful models to elucidate epigenetic modifications resulting from gene–environment interactions. Yet, commonly a limited number of clinical twin samples are available, leading to an underpowered ... -
High-Specificity Targeted Functional Profiling in Microbial Communities with ShortBRED
(Public Library of Science, 2015)Profiling microbial community function from metagenomic sequencing data remains a computationally challenging problem. Mapping millions of DNA reads from such samples to reference protein databases requires long run-times, ... -
High-Throughput Screening Platform for Engineered Nanoparticle-Mediated Genotoxicity Using CometChip Technology
(American Chemical Society, 2014)The likelihood of intentional and unintentional engineered nanoparticle (ENP) exposure has dramatically increased due to the use of nanoenabled products. Indeed, ENPs have been incorporated in many useful products and have ... -
High-Throughput Sequencing Enhanced Phage Display Identifies Peptides That Bind Mycobacteria
(Public Library of Science, 2013)Bacterial cell wall components have been previously used as infection biomarkers detectable by antibodies. However, it is possible that the surface of the Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis ... -
High-throughput Sorting of Mosquito Larvae for Laboratory Studies and for Future Vector Control Interventions
(BioMed Central, 2012)Background: Mosquito transgenesis offers new promises for the genetic control of vector-borne infectious diseases such as malaria and dengue fever. Genetic control strategies require the release of large number of male ... -
Higher Carbohydrate Antigen 125 Levels Are Associated with Increased Risk of Coronary Heart Disease in Elderly Chinese: A Population-Based Case-Control Study
(Public Library of Science, 2013)Background: High carbohydrate antigen 125 (CA-125) level was reported to be associated with some cardiac dysfunctions, such as chronic heart failure, but the relationship between CA-125 level and coronary heart disease ... -
Higher incidence of premenopausal breast cancer in less developed countries; myth or truth?
(BioMed Central, 2014)Background: Fundamental etiologic differences have been suggested to cause earlier onset of breast cancer in less developed countries (LDCs) than in more developed countries (MDCs). We explored this hypothesis using ... -
Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance
(Nature Publishing Group, 2015)Betatrophin/ANGPTL8 is a newly identified hormone produced in liver and adipose tissue that has been shown to be induced as a result of insulin resistance and regulates lipid metabolism. Little is known about betatrophin ... -
Higher Predicted Vitamin D Status Is Associated with Reduced Risk of Crohn's Disease
(BMC, 2012)BACKGROUND and AIMS: Vitamin D influences innate immunity, which is believed to be involved in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC). However, data examining vitamin D status in relation to ... -
Higher risk of death and stroke in patients with persistent vs. paroxysmal atrial fibrillation: results from the ROCKET-AF Trial
(Oxford University Press, 2014)Aim Anticoagulation prophylaxis for stroke is recommended for at-risk patients with either persistent or paroxysmal atrial fibrillation (AF). We compared outcomes in patients with persistent vs. paroxysmal AF receiving ... -
Higher Serum Levels of Vitamin D are Associated with Reduced Risk of Diverticulitis
(Elsevier, 2013)BACKGROUND and AIMS: Recent studies have shown geographic and seasonal variations in hospital admissions for diverticulitis. Because this variation parallels differences in ultraviolet light exposure, the most important ... -
“His Mind Will Work Better With Both of Us”: A Qualitative Study on Fathers’ Roles and Coparenting of Young Children in Rural Pakistan
(BMC, 2018-11-20)Background Parents are the primary providers of nurturing care for young children’s healthy early development. However, the literature on parenting in early childhood, especially in low- and middle-income countries, has ... -
A histological method for quantifying Plasmodium falciparum in the brain in fatal paediatric cerebral malaria
(BioMed Central, 2013)Background: The sequestration of Plasmodium falciparum-infected erythrocytes in brain microvasculature through cytoadherence to endothelium, is the hallmark of the definitive diagnosis of cerebral malaria and plays a ... -
Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes
(Public Library of Science, 2014)Resting memory CD4+ T-cells harboring latent HIV proviruses represent a critical barrier to viral eradication. Histone deacetylase inhibitors (HDACis), such as suberanilohydroxamic acid (SAHA), romidepsin, and panobinostat ... -
Histone Modifications Are Associated with Transcript Isoform Diversity in Normal and Cancer Cells
(Public Library of Science, 2014)Mechanisms that generate transcript diversity are of fundamental importance in eukaryotes. Although a large fraction of human protein-coding genes and lincRNAs produce more than one mRNA isoform each, the regulation of ... -
Historical Zoonoses and Other Changes in Host Tropism of Staphylococcus aureus, Identified by Phylogenetic Analysis of a Population Dataset
(Public Library of Science, 2013)Background: Staphylococcus aureus exhibits tropisms to many distinct animal hosts. While spillover events can occur wherever there is an interface between host species, changes in host tropism only occur with the establishment ... -
History of peptic ulcer disease and pancreatic cancer risk in men
(Elsevier, 2010)BACKGROUND and AIMS: Peptic ulcer disease has been associated with an increased risk of pancreatic cancer, but findings on this topic are inconsistent. We investigated the association between pancreatic cancer and the ... -
HIV and Hepatitis C Mortality in Massachusetts, 2002–2011: Spatial Cluster and Trend Analysis of HIV and HCV Using Multiple Cause of Death
(Public Library of Science, 2014)Background: Infectious diseases, while associated with a much smaller proportion of deaths than they were 50 years ago, still play a significant role in mortality across the state of Massachusetts. Most analysis of infectious ... -
HIV associated high-risk HPV infection among Nigerian women
(BioMed Central, 2013)Background: In developed countries, the incidence of cervical cancer has remained stable in HIV+ women but the prevalence and multiplicity of high-risk HPV (hrHPV) infection, a necessary cause of cervical cancer, appears ...