Browsing SPH Scholarly Articles by Title

Now showing items 2982-3001 of 6362

    • Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection 

      Nunes-Alves, Cláudio; Booty, Matthew G.; Carpenter, Stephen M.; Rothchild, Alissa C.; Martin, Constance J.; Desjardins, Danielle; Steblenko, Katherine; Kløverpris, Henrik N.; Madansein, Rajhmun; Ramsuran, Duran; Leslie, Alasdair; Correia-Neves, Margarida; Behar, Samuel M. (Public Library of Science, 2015)
      The immune system can recognize virtually any antigen, yet T cell responses against several pathogens, including Mycobacterium tuberculosis, are restricted to a limited number of immunodominant epitopes. The host factors ...

    • Human Brown Adipose Tissue Is Phenocopied by Classical Brown Adipose Tissue in Physiologically Humanized Mice 

      Sun, Wenfei; Frontini, Andrea; Balaz, Miroslav; Jespersen, Naja Z.; Feizi, Amir; Petrovic, Katarina; Bokhari, Muhammad Hamza; Niemi, Tarja; Nuutila, Pirjo; Cinti, Saverio; Nielsen, Søren; Scheele, Camilla; Virtanen, Kirsi; Cannon, Barbara; Nedergaard, Jan; Wolfrum, Christian; Petrovic, Natasa; Fischer, Alexander; de Jong, Jasper; Pires, Nuno (Springer Science and Business Media LLC, 2019-08)
      Human and rodent brown adipose tissues (BAT) appear morphologically and molecularly different. Here we compare human BAT with both classical brown and brite/beige adipose tissues of ‘physiologically humanized’ mice: ...

    • Human Cerebral Malaria and Plasmodium falciparum Genotypes in Malawi 

      Milner, Danny Arnold; Vareta, Jimmy; Valim, Clarissa; Montgomery, Jacqui; Daniels, Rachel Fath; Cooke, Sarah Volkman; Neafsey, Daniel Edward; Park, Daniel John; Schaffner, Stephen; Mahesh, Nira C; Barnes, Kayla G; Rosen, David M; Lukens, Amanda Kathleen; Van-Tyne, Daria; Wiegand, Roger C.; Sabeti, Pardis Christine; Seydel, Karl B; Glover, Simon J; Kamiza, Steve; Molyneux, Malcolm E; Taylor, Terrie E; Wirth, Dyann Fergus (BioMed Central, 2012)
      Background: Cerebral malaria, a severe form of Plasmodium falciparum infection, is an important cause of mortality in sub-Saharan African children. A Taqman 24 Single Nucleotide Polymorphisms (SNP) molecular barcode assay ...

    • Human Challenge Studies to Accelerate Coronavirus Vaccine Licensure 

      Eyal, Nir; Lipsitch, Marc; Smith, Peter G. (2020-03)
      Controlled human challenge trials of SARS-CoV-2 vaccine candidates could accelerate the testing and potential rollout of efficacious vaccines. By replacing conventional Phase 3 testing of vaccine candidates, such trials ...

    • Human eosinophil leukocytes express protein disulfide isomerase in secretory granules and vesicles: Ultrastructural studies 

      Dias, F. F.; Amaral, K. B.; Carmo, L. A. S.; Shamri, R.; Dvorak, Ann Marie; Weller, Peter Fahey; Melo, Rossana (Journal of Histochemistry & Cytochemistry (The Histochemical Society), 2014)
      Protein disulfide isomerase (PDI) has fundamental roles in the oxidative folding of proteins in the endoplasmic reticulum (ER) of eukaryotic cells. The study of this molecule has been attracting considerable attention due ...

    • Human Eosinophils Secrete Preformed, Granule-Stored Interleukin-4 Through Distinct Vesicular Compartments 

      Melo, Rossana C. N.; Spencer, Lisa A.; Perez, Sandra A. C.; Ghiran, Ionita; Dvorak, Ann M.; Weller, Peter Fahey (Wiley-Blackwell, 2005)
      Secretion of interleukin-4 (IL-4) by leukocytes is important for varied immune responses including allergic inflammation. Within eosinophils, unlike lymphocytes, IL-4 is stored in granules (termed specific granules) and ...

    • Human exposure to nitro musks and the evaluation of their potential toxicity: an overview 

      Taylor, Kathryn M; Weisskopf, Marc; Shine, James (BioMed Central, 2014)
      Synthetic nitro musks are fragrant chemicals found in household and personal care products. The use of these products leads to direct exposures via dermal absorption, as well as inhalation of contaminated dust and volatilized ...

    • Human Exposures to Bisphenol A, Bisphenol F and Chlorinated Bisphenol A Derivatives and Thyroid Function 

      Andrianou, Xanthi D.; Gängler, Stephanie; Piciu, Andra; Charisiadis, Pantelis; Zira, Christina; Aristidou, Kyriacos; Piciu, Doina; Hauser, Russ; Makris, Konstantinos C. (Public Library of Science, 2016)
      Although the increasing prevalence of thyroid nodular disease (TND) has been partially attributed to the more frequent usage of improved diagnostics, environmental factors, such as exposures to thyroid-disrupting chemicals ...

    • Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response 

      Pulloor, Niyas Kudukkil; Nair, Sajith; Kostic, Aleksandar D.; Bist, Pradeep; Weaver, Jeremy D.; Riley, Andrew M.; Tyagi, Richa; Uchil, Pradeep D.; York, John D.; Snyder, Solomon H.; García-Sastre, Adolfo; Potter, Barry V. L.; Lin, Rongtuan; Shears, Stephen B.; Xavier, Ramnik J.; Krishnan, Manoj N. (Public Library of Science, 2014)
      The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I signaling is only partially understood. Using a human genome-wide RNAi-screen, we identified 226 ...

    • Human Immunodeficiency Virus Infection in Mexico City: Rectal Bleeding and Anal Warts as Risk Factors among Men Reporting Sex with Men 

      Coplan, P. M.; Gortmaker, S.; Hemandez-Avila, M.; Spiegelman, D.; Uribe-Zuuiga, P.; Mueller, N. E. (Oxford University Press, 1996)

    • Human Immunodeficiency Virus Type 1 Specific Cytotoxic T Lymphocyte Responses in Chinese Infected with HIV-1 B'/C Recombinant (CRF07_BC) 

      Chen, Jianping; Hong, Kunxue; Jia, Mingming; Liu, Hongwei; Zhang, Yuanzhi; Zhang, Xiaoqing; Zhao, Hongjing; Peng, Hong; Ma, Pengfei; Xing, Hui; Ruan, Yuhua; Shao, Yiming; Liu, Sha; Altfeld, Marcus; Walker, Bruce David; Williams, Katie L.; Yu, Xu G. (BioMed Central, 2007)
      Background: The characterization of HIV-1-specific T cell responses in people infected with locally circulating HIV-1 strain will facilitate the development of HIV-1 vaccine. Sixty intravenous drug users infected with HIV-1 ...

    • The Human Microbiome Project: A Community Resource for the Healthy Human Microbiome 

      Gevers, Dirk; Knight, Rob; Petrosino, Joseph F.; Huang, Katherine; McGuire, Amy L.; Birren, Bruce W.; Nelson, Karen E.; White, Owen; Methé, Barbara A.; Huttenhower, Curtis (Public Library of Science, 2012)
      This manuscript describes the NIH Human Microbiome Project, including a brief review of human microbiome research, a history of the project, and a comprehensive overview of the consortium's recent collection of publications ...

    • Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013 

      Ravel, Jacques; Blaser, Martin J; Braun, Jonathan; Brown, Eric; Bushman, Frederic D; Chang, Eugene B; Davies, Julian; Dewey, Kathryn G; Dinan, Timothy; Dominguez-Bello, Maria; Erdman, Susan E; Finlay, B Brett; Garrett, Wendy S; Huffnagle, Gary B; Huttenhower, Curtis; Jansson, Janet; Jeffery, Ian B; Jobin, Christian; Khoruts, Alexander; Kong, Heidi H; Lampe, Johanna W; Ley, Ruth E; Littman, Dan R; Mazmanian, Sarkis K; Mills, David A; Neish, Andrew S; Petrof, Elaine; Relman, David A; Rhodes, Rosamond; Turnbaugh, Peter J; Young, Vincent B; Knight, Rob; White, Owen (BioMed Central, 2014)
      A conference entitled ‘Human microbiome science: Vision for the future’ was organized in Bethesda, MD from July 24 to 26, 2013. The event brought together experts in the field of human microbiome research and aimed at ...

    • Human Movement Data for Malaria Control and Elimination Strategic Planning 

      Pindolia, Deepa K; Garcia, Andres J; Wesolowski, Amy; Smith, David L; Buckee, Caroline O; Noor, Abdisalan M; Snow, Robert W; Tatem, Andrew J (BioMed Central, 2012)
      Recent increases in funding for malaria control have led to the reduction in transmission in many malaria endemic countries, prompting the national control programmes of 36 malaria endemic countries to set elimination ...

    • Human papillomavirus infection in the oral cavity of HIV patients is not reduced by initiating antiretroviral therapy 

      Shiboski, Caroline H.; Lee, Anthony; Chen, Huichao; Webster-Cyriaque, Jennifer; Seaman, Todd; Landovitz, Raphael J.; John, Malcolm; Reilly, Nancy; Naini, Linda; Palefsky, Joel; Jacobson, Mark A. (Lippincott Williams & Wilkins, 2016)
      Objective: The incidence of human papillomavirus (HPV)-related oral malignancies is increasing among HIV-infected populations, and the prevalence of oral warts has reportedly increased among HIV patients receiving ...

    • Human Papillomavirus Vaccine Introduction in Low-Income and Middle-Income Countries: Guidance on the Use of Cost-Effectiveness Models 

      Jit, Mark; Demarteau, Nadia; Elbasha, Elamin; Ginsberg, Gary; Kim, Jane Jooyun; Praditsitthikorn, Naiyana; Sinanovic, Edina; Hutubessy, Raymond (BioMed Central, 2011)
      Background: The World Health Organization (WHO) recommends that the cost effectiveness of introducing human papillomavirus (HPV) vaccination is considered before such a strategy is implemented. However, developing countries ...

    • Human Resources for Treating HIV/AIDS: Are the Preventive Effects of Antiretroviral Treatment a Game Changer? 

      Bärnighausen, Till; Bloom, David E.; Humair, Salal (Public Library of Science, 2016)
      Shortages of human resources for treating HIV/AIDS (HRHA) are a fundamental barrier to reaching universal antiretroviral treatment (ART) coverage in developing countries. Previous studies suggest that recruiting HRHA to ...

    • Human Rights 

      Marks, Stephen P. (M.E. Sharpe, 2013)

    • Human Rights and the Challenges of Science and Technology 

      Marks, Stephen P. (Springer Science + Business Media, 2014)
      The expansion of the corpus of international human rights to include the right to water and sanitation has implications both for the process of recognizing human rights and for future developments in the relationships ...

    • Human rights violations and smoking status among South African adults enrolled in the South Africa Stress and Health (SASH) study 

      Dutra, Lauren M.; Williams, David R.; Gupta, Jhumka; Kawachi, Ichiro; Okechukwu, Cassandra A. (2014)
      Despite South Africa's history of violent political conflict, and the link between stressful experiences and smoking in the literature, no public health study has examined South Africans' experiences of human rights ...